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Spyre Therapeutics
SYRE

Overview Fund Activity

127 hedge funds and large institutions have $950M invested in Spyre Therapeutics in 2025 Q2 according to their latest regulatory filings, with 18 funds opening new positions, 61 increasing their positions, 26 reducing their positions, and 17 closing their positions.

Holders
127
Holders Change
-2
Holders Change %
-1.55%
% of All Funds
1.71%
Holding in Top 10
3
Holding in Top 10 Change
+1
Holding in Top 10 Change %
+50%
% of All Funds
0.04%
New
18
Increased
61
Reduced
26
Closed
17
Calls
$1.05M
Puts
$603K
Net Calls
+$446K
Net Calls Change
+$628K

Top Buyers

1
TCM
1
Tang Capital Management
California
$47.9M
2
T. Rowe Price Associates
2
T. Rowe Price Associates
Maryland
$13.9M
3
BBA
3
Baker Bros. Advisors
New York
$9.38M
4
BlackRock
4
BlackRock
New York
$60M
5
Morgan Stanley
5
Morgan Stanley
New York
$10M

Top Sellers

1
Janus Henderson Group
1
Janus Henderson Group
United Kingdom
$194K
2
PA
2
Perceptive Advisors
New York
$22.9M
3
DCM
3
Driehaus Capital Management
Illinois
$31.2M
4
PBA
4
Paradigm Biocapital Advisors
New York
$28M
5
Adage Capital Partners
5
Adage Capital Partners
Massachusetts
$9.13M
Name Market Value Shares Shares
Change 		Shares
Change %
TRSOTSOK
76
Teachers Retirement System of the State of Kentucky
Kentucky
$386K 25,799 – –
IIM
77
INTECH Investment Management
Florida
$373K 24,945 +4,517 +22%
N
78
Natixis
France
$355K 20,040 +20,040 New
Assenagon Asset Management
79
Assenagon Asset Management
Luxembourg
$331K 22,136 -590 -3%
WA
80
Waverly Advisors
Alabama
$291K 19,453 +23 +0.1%
NC
81
NBW Capital
Massachusetts
$291K 19,430 – –
GEM
82
Global Endowment Management
North Carolina
$272K 18,184 – –
AQR Capital Management
83
AQR Capital Management
Connecticut
$269K 17,973 +17,973 New
New York State Common Retirement Fund
84
New York State Common Retirement Fund
New York
$248K 16,565 +6,300 +61%
VOYA Investment Management
85
VOYA Investment Management
Georgia
$203K 13,589 +3,241 +31%
Janus Henderson Group
86
Janus Henderson Group
United Kingdom
$194K 13,000 -1,028,410 -99%
Zurich Cantonal Bank
87
Zurich Cantonal Bank
Switzerland
$193K 12,873 +12,873 New
ProShare Advisors
88
ProShare Advisors
Maryland
$187K 12,479 +1,101 +10%
CUAMC
89
China Universal Asset Management Company
China
$181K 12,122 +35 +0.3%
PFSRSONJ
90
Police & Firemen's Retirement System of New Jersey
New Jersey
$173K 11,525 +2,758 +31%
PA
91
Profund Advisors
Maryland
$165K 11,043 -3,619 -25%
Man Group
92
Man Group
United Kingdom
$162K 10,843 +10,843 New
ASRS
93
Arizona State Retirement System
Arizona
$157K 10,512 +495 +5%
Royal Bank of Canada
94
Royal Bank of Canada
Ontario, Canada
$126K 8,474 +6,302 +290%
KK
95
KLP Kapitalforvaltning
Norway
$117K 7,800 – –
TRCT
96
Tower Research Capital (TRC)
New York
$86.4K 5,769 +3,725 +182%
VIA
97
Virtus Investment Advisers
Connecticut
$79.5K 5,310 -1,551 -23%
AIP
98
Ameritas Investment Partners
Nebraska
$76.2K 5,091 +1,045 +26%
A
99
AlphaQuest
New York
$62.5K 4,174 +983 +31%
Mirae Asset Global Investments
100
Mirae Asset Global Investments
South Korea
$34.9K 2,331 +315 +16%
2 3
4
5 6