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Spyre Therapeutics
SYRE

Overview Fund Activity

127 hedge funds and large institutions have $950M invested in Spyre Therapeutics in 2025 Q2 according to their latest regulatory filings, with 18 funds opening new positions, 61 increasing their positions, 26 reducing their positions, and 17 closing their positions.

Holders
127
Holders Change
-2
Holders Change %
-1.55%
% of All Funds
1.71%
Holding in Top 10
3
Holding in Top 10 Change
+1
Holding in Top 10 Change %
+50%
% of All Funds
0.04%
New
18
Increased
61
Reduced
26
Closed
17
Calls
$1.05M
Puts
$603K
Net Calls
+$446K
Net Calls Change
+$628K

Top Buyers

1
TCM
1
Tang Capital Management
California
$47.9M
2
T. Rowe Price Associates
2
T. Rowe Price Associates
Maryland
$13.9M
3
BBA
3
Baker Bros. Advisors
New York
$9.38M
4
BlackRock
4
BlackRock
New York
$60M
5
Morgan Stanley
5
Morgan Stanley
New York
$10M

Top Sellers

1
Janus Henderson Group
1
Janus Henderson Group
United Kingdom
$194K
2
PA
2
Perceptive Advisors
New York
$22.9M
3
DCM
3
Driehaus Capital Management
Illinois
$31.2M
4
PBA
4
Paradigm Biocapital Advisors
New York
$28M
5
Adage Capital Partners
5
Adage Capital Partners
Massachusetts
$9.13M
Name Market Value Shares Shares
Change 		Shares
Change %
Fidelity Investments
1
Fidelity Investments
Massachusetts
$136M 9,053,034 +14,481 +0.2%
FFM
2
Fairmount Funds Management
Pennsylvania
$60.2M 4,018,101 – –
BlackRock
3
BlackRock
New York
$60M 4,007,296 +434,622 +12%
RI
4
RTW Investments
New York
$54.2M 3,621,996 – –
TCM
5
Tang Capital Management
California
$47.9M 3,200,000 +1,150,000 +56%
Vanguard Group
6
Vanguard Group
Pennsylvania
$45.9M 3,066,586 +168,319 +6%
VA
7
VR Adviser
New York
$40.2M 2,685,448 – –
B
8
Braidwell
Connecticut
$38.6M 2,578,404 – –
Capital International Investors
9
Capital International Investors
California
$35.8M 2,392,541 – –
DCM
10
Driehaus Capital Management
Illinois
$31.2M 2,085,590 -631,722 -23%
CC
11
Commodore Capital
New York
$29.8M 1,988,084 – –
PBA
12
Paradigm Biocapital Advisors
New York
$28M 1,870,445 -256,760 -12%
State Street
13
State Street
Massachusetts
$23.9M 1,595,291 -101,824 -6%
PA
14
Perceptive Advisors
New York
$22.9M 1,529,445 -783,827 -34%
Wellington Management Group
15
Wellington Management Group
Massachusetts
$22.7M 1,513,478 -80,200 -5%
JFG
16
Jefferies Financial Group
New York
$20.8M 1,388,854 +140,000 +11%
Geode Capital Management
17
Geode Capital Management
Massachusetts
$18.4M 1,227,232 +167,669 +16%
Pictet Asset Management
18
Pictet Asset Management
Switzerland
$16.2M 1,079,443 +10,551 +1%
T. Rowe Price Associates
19
T. Rowe Price Associates
Maryland
$13.9M 930,481 +681,939 +274%
Franklin Resources
20
Franklin Resources
California
$11.9M 795,275 +34,647 +5%
PCH
21
Polar Capital Holdings
United Kingdom
$11.2M 745,000 -80,000 -10%
Morgan Stanley
22
Morgan Stanley
New York
$10M 671,044 +335,577 +100%
BBA
23
Baker Bros. Advisors
New York
$9.38M 626,703 +626,703 New
DM
24
Deerfield Management
New York
$9.19M 613,665 +163,665 +36%
Adage Capital Partners
25
Adage Capital Partners
Massachusetts
$9.13M 610,200 -193,000 -24%
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