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Spyre Therapeutics
SYRE

Overview Fund Activity

77 hedge funds and large institutions have $137M invested in Spyre Therapeutics in 2019 Q2 according to their latest regulatory filings, with 16 funds opening new positions, 35 increasing their positions, 9 reducing their positions, and 8 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
77
Holders Change
+6
Holders Change %
+8.45%
% of All Funds
1.68%
Holding in Top 10
3
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-25%
% of All Funds
0.07%
New
16
Increased
35
Reduced
9
Closed
8
Calls
–
Puts
$1K
Net Calls
-$1K
Net Calls Change
-$1K

Top Buyers

1
BlackRock
BlackRock
New York
+$2.5M
2
Marshall Wace
Marshall Wace
United Kingdom
+$1.94M
3
NCM
Nantahala Capital Management
Connecticut
+$1.37M
4
AG
Artal Group
Luxembourg
+$1.16M
5
State Street
State Street
Massachusetts
+$954K

Top Sellers

1
Jennison Associates
Jennison Associates
New York
-$6.25M
2
SFM
Sphera Funds Management
Israel
-$5.4M
3
CH
CVI Holdings
Delaware
-$2.19M
4
Citadel Advisors
Citadel Advisors
Florida
-$611K
5
MWNA
Marshall Wace North America
New York
-$179K
Name Holding Trade Value Shares
Change 		Shares
Change %
NCM
1
Nantahala Capital Management
Connecticut
$19.5M +$1.37M +8,000 +8%
O
2
OrbiMed
New York
$14.8M – – –
BlackRock
3
BlackRock
New York
$12.7M +$2.5M +14,573 +24%
BBA
4
Baker Bros. Advisors
New York
$11.7M – – –
Adage Capital Partners
5
Adage Capital Partners
Massachusetts
$10.1M – – –
ACM
6
Aisling Capital Management
New York
$8.84M +$481K +2,810 +6%
Vanguard Group
7
Vanguard Group
Pennsylvania
$7.57M -$37.7K -220 -0.5%
RSCM
8
Rock Springs Capital Management
Maryland
$5.48M – – –
Marshall Wace
9
Marshall Wace
United Kingdom
$4.51M +$1.94M +11,312 +75%
Renaissance Technologies
10
Renaissance Technologies
New York
$3.73M +$625K +3,648 +20%
Dimensional Fund Advisors
11
Dimensional Fund Advisors
Texas
$3.56M +$473K +2,760 +15%
DM
12
Deerfield Management
New York
$3.43M – – –
Goldman Sachs
13
Goldman Sachs
New York
$2.71M -$50.3K -294 -2%
State Street
14
State Street
Massachusetts
$2.63M +$954K +5,570 +57%
UOTTAIMCU
15
University of Texas/Texas AM Investment Management Co (UTIMCO)
Texas
$2.3M – – –
Geode Capital Management
16
Geode Capital Management
Massachusetts
$2.05M +$400K +2,334 +24%
RWM
17
Ritholtz Wealth Management
New York
$1.99M – – –
A
18
Abingworth
United Kingdom
$1.64M – – –
Northern Trust
19
Northern Trust
Illinois
$1.61M +$128K +747 +9%
Assenagon Asset Management
20
Assenagon Asset Management
Luxembourg
$1.42M +$779K +4,551 +121%
FI
21
Fosun International
China
$1.31M +$180K +1,120 +16%
SFM
22
Sphera Funds Management
Israel
$1.28M -$5.4M -31,512 -81%
AG
23
Artal Group
Luxembourg
$1.16M +$1.16M +6,758 New
Nuveen Asset Management
24
Nuveen Asset Management
Illinois
$951K +$951K +5,556 New
BCM
25
Bridgeway Capital Management
Texas
$702K – – –
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