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Spyre Therapeutics
SYRE

Overview Fund Activity

23 hedge funds and large institutions have $38.5M invested in Spyre Therapeutics in 2017 Q1 according to their latest regulatory filings, with 7 funds opening new positions, 5 increasing their positions, 5 reducing their positions, and 7 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
23
Holders Change
-3
Holders Change %
-11.54%
% of All Funds
0.57%
Holding in Top 10
1
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.02%
New
7
Increased
5
Reduced
5
Closed
7
Calls
–
Puts
–
Net Calls
–
Net Calls Change
–

Top Buyers

1
O
OrbiMed
New York
+$814K
2
Vanguard Group
Vanguard Group
Pennsylvania
+$617K
3
NI
Numeric Investors
Massachusetts
+$294K
4
Renaissance Technologies
Renaissance Technologies
New York
+$270K
5
Bank of New York Mellon
Bank of New York Mellon
New York
+$157K

Top Sellers

1
BBA
Baker Bros. Advisors
New York
-$1.6M
2
VMI
VHCP Management II
New York
-$1.52M
3
PA
Perceptive Advisors
New York
-$722K
4
Norges Bank
Norges Bank
Norway
-$275K
5
SCM
Sio Capital Management
New York
-$138K
Name Holding Trade Value Shares
Change 		Shares
Change %
O
1
OrbiMed
New York
$10.9M +$814K +4,372 +8%
Jennison Associates
2
Jennison Associates
New York
$10.8M +$65.6K +352 +0.6%
UOTTAIMCU
3
University of Texas/Texas AM Investment Management Co (UTIMCO)
Texas
$3.91M – – –
RSCM
4
Rock Springs Capital Management
Maryland
$3.9M – – –
DCM
5
DAFNA Capital Management
California
$2.61M – – –
BBA
6
Baker Bros. Advisors
New York
$1.42M -$1.6M -8,570 -53%
SCM
7
Sio Capital Management
New York
$1.27M -$138K -743 -10%
Vanguard Group
8
Vanguard Group
Pennsylvania
$1.03M +$617K +3,314 +151%
Alyeska Investment Group
9
Alyeska Investment Group
Illinois
$881K -$10.2K -55 -1%
NI
10
Numeric Investors
Massachusetts
$294K +$294K +1,580 New
Renaissance Technologies
11
Renaissance Technologies
New York
$270K +$270K +1,448 New
Geode Capital Management
12
Geode Capital Management
Massachusetts
$246K +$73.1K +394 +42%
LF
13
Lee Financial
Texas
$167K – – –
Bank of New York Mellon
14
Bank of New York Mellon
New York
$157K +$157K +842 New
Northern Trust
15
Northern Trust
Illinois
$123K +$123K +660 New
Wells Fargo
16
Wells Fargo
California
$117K -$11.7K -63 -9%
BlackRock
17
BlackRock
New York
$113K +$113K +606 New
Squarepoint
18
Squarepoint
New York
$91K +$91K +488 New
PA
19
Perceptive Advisors
New York
$43K -$722K -3,910 -94%
Deutsche Bank
20
Deutsche Bank
Germany
$36K +$36K +198 New
IA
21
IFP Advisors
Florida
$21K – – –
Morgan Stanley
22
Morgan Stanley
New York
$20K – – –
UBS Group
23
UBS Group
Switzerland
$7K +$1.26K +7 +22%
VMI
24
VHCP Management II
New York
– -$1.52M -14,005 Closed
Norges Bank
25
Norges Bank
Norway
– -$275K -2,528 Closed
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