BBA

Baker Bros. Advisors’s Spyre Therapeutics SYRE Stock Holding History

Quarter	Market Value	Status	Shares	Shares Change %	Trade Value	Portfolio Weight	Portfolio Position
2025 Q2	$9.38M	Buy	+626,703	New	+$9.38M	0.09%	54
2023 Q3	–	Sell	-3,410,106	Closed	-$1.54M	–	108
2023 Q2	$1.54M	Hold	3,410,106	–	–	0.01%	100
2023 Q1	$989K	Hold	3,410,106	–	–	0.01%	99
2022 Q4	$1.53M	Hold	3,410,106	–	–	0.01%	101
2022 Q3	$1.79M	Hold	3,410,106	–	–	0.01%	101
2022 Q2	$1.72M	Hold	3,410,106	–	–	0.01%	98
2022 Q1	$7.84M	Hold	3,410,106	–	–	0.05%	71
2021 Q4	$16.2M	Hold	3,410,106	–	–	0.08%	62
2021 Q3	$27.1M	Hold	3,410,106	–	–	0.12%	54
2021 Q2	$23.7M	Hold	3,410,106	–	–	0.1%	62
2021 Q1	$27M	Hold	3,410,106	–	–	0.12%	56
2020 Q4	$26.8M	Sell	3,410,106 -969,486	-22%	-$7.63M	0.1%	51
2020 Q3	$31.1M	Hold	4,379,592	–	–	0.12%	42
2020 Q2	$40.5M	Buy	4,379,592 +2,665,988	+156%	+$24.7M	0.18%	36
2020 Q1	$7.99M	Hold	1,713,604	–	–	0.05%	54
2019 Q4	$13.1M	Hold	1,713,604	–	–	0.07%	51
2019 Q3	$13.2M	Hold	1,713,604	–	–	0.09%	49
2019 Q2	$11.7M	Hold	1,713,604	–	–	0.08%	49
2019 Q1	$13.8M	Hold	1,713,604	–	–	0.09%	43
2018 Q4	$12.8M	Buy	1,713,604 +325,732	+23%	+$2.44M	0.11%	45
2018 Q3	$13.3M	Hold	1,387,872	–	–	0.09%	49
2018 Q2	$14.7M	Buy	1,387,872 +250,000	+22%	+$2.65M	0.11%	51
2018 Q1	$11.3M	Hold	1,137,872	–	–	0.1%	54
2017 Q4	$6.16M	Hold	1,137,872	–	–	0.05%	71
2017 Q3	$5.61M	Hold	1,137,872	–	–	0.05%	74
2017 Q2	$4.38M	Buy	1,137,872 +947,885	+499%	+$3.65M	0.04%	66
2017 Q1	$1.42M	Sell	189,987 -214,243	-53%	-$1.6M	0.01%	94
2016 Q4	$1.76M	Hold	404,230	–	–	0.02%	94
2016 Q3	$2.59M	Hold	404,230	–	–	0.02%	87
2016 Q2	$1.97M	Buy	+404,230	New	+$1.97M	0.02%	98