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RTW Investments’s Spyre Therapeutics SYRE Stock Holding History

RTW Investments’s Portfolio SYRE Stock Details SYRE Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		$210M Hold
4,171,996
– – 2.09% 14
2025
Q4 		$137M Buy
4,171,996
+550,000
+15% +$14.4M 1.37% 23
2025
Q3 		$60.7M Hold
3,621,996
– – 0.75% 35
2025
Q2 		$54.2M Hold
3,621,996
– – 0.77% 34
2025
Q1 		$58.4M Hold
3,621,996
– – 0.89% 29
2024
Q4 		$84.3M Buy
3,621,996
+363,636
+11% +$10.7M 1.28% 26
2024
Q3 		$95.8M Hold
3,258,360
– – 1.39% 28
2024
Q2 		$76.6M Buy
3,258,360
+1,025,600
+46% +$34.6M 1.19% 28
2024
Q1 		$84.7M Hold
2,232,760
– – 1.25% 30
2023
Q4 		$48M Buy
+2,232,760
New +$30.8M 0.75% 34

Other funds holding SYRE

Fidelity Investments
Fidelity Investments Boston, Massachusetts $1.9T AUM 41.92% 1-Year Est. Return
BlackRock
BlackRock New York $5.7T AUM 30.48% 1-Year Est. Return
FFM
Fairmount Funds Management West Conshohocken, Pennsylvania $1.38B AUM 407.79% 1-Year Est. Return
PA
Perceptive Advisors New York $5.06B AUM 314.02% 1-Year Est. Return
VA
VR Adviser New York $2.68B AUM 422.73% 1-Year Est. Return
VCM
Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM
DCM
Driehaus Capital Management Chicago, Illinois $13.6B AUM 173.98% 1-Year Est. Return
State Street
State Street Boston, Massachusetts $2.9T AUM 29.55% 1-Year Est. Return
PBA
Paradigm Biocapital Advisors New York $4.89B AUM 251.12% 1-Year Est. Return
CC
Commodore Capital New York $1.73B AUM 298.96% 1-Year Est. Return