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Spyre Therapeutics
SYRE

Overview Fund Activity

107 hedge funds and large institutions have $1.18B invested in Spyre Therapeutics in 2024 Q2 according to their latest regulatory filings, with 29 funds opening new positions, 47 increasing their positions, 17 reducing their positions, and 24 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
107
Holders Change
+4
Holders Change %
+3.88%
% of All Funds
1.56%
Holding in Top 10
3
Holding in Top 10 Change
-2
Holding in Top 10 Change %
-40%
% of All Funds
0.04%
New
29
Increased
47
Reduced
17
Closed
24
Calls
$61K
Puts
$35K
Net Calls
+$26K
Net Calls Change
-$50K

Top Buyers

1
FFM
Fairmount Funds Management
Pennsylvania
+$85.6M
2
B
Braidwell
Connecticut
+$47M
3
BlackRock
BlackRock
New York
+$43.4M
4
Vanguard Group
Vanguard Group
Pennsylvania
+$33.3M
5
State Street
State Street
Massachusetts
+$30M

Top Sellers

1
YF
Yu Fan
-$16.4M
2
Millennium Management
Millennium Management
New York
-$12.1M
3
CAM
Cormorant Asset Management
Massachusetts
-$9.48M
4
Marshall Wace
Marshall Wace
United Kingdom
-$6.14M
5
Susquehanna International Group
Susquehanna International Group
Pennsylvania
-$3.85M
Name Holding Trade Value Shares
Change 		Shares
Change %
Fidelity Investments
1
Fidelity Investments
Massachusetts
$177M +$21.7M +924,228 +14%
FFM
2
Fairmount Funds Management
Pennsylvania
$94.5M +$85.6M +3,639,680 +962%
RI
3
RTW Investments
New York
$76.6M +$24.1M +1,025,600 +46%
PA
4
Perceptive Advisors
New York
$71.3M +$11.2M +474,339 +19%
VA
5
VR Adviser
New York
$63.1M +$12.1M +513,666 +24%
B
6
Braidwell
Connecticut
$59.1M +$47M +1,999,538 +388%
BlackRock
7
BlackRock
New York
$56.5M +$43.4M +1,846,750 +332%
CC
8
Commodore Capital
New York
$46.7M +$2.45M +104,000 +6%
Vanguard Group
9
Vanguard Group
Pennsylvania
$44.9M +$33.3M +1,414,385 +284%
ACA
10
Avoro Capital Advisors
New York
$43.2M – – –
DTC
11
Deep Track Capital
Connecticut
$41.3M +$12.8M +543,247 +45%
State Street
12
State Street
Massachusetts
$33.1M +$30M +1,275,233 +949%
Adage Capital Partners
13
Adage Capital Partners
Massachusetts
$27.1M +$1.11M +47,211 +4%
Goldman Sachs
14
Goldman Sachs
New York
$21M +$15.4M +653,168 +272%
Wellington Management Group
15
Wellington Management Group
Massachusetts
$18.7M -$398K -16,914 -2%
Geode Capital Management
16
Geode Capital Management
Massachusetts
$18M +$10.2M +435,609 +132%
Franklin Resources
17
Franklin Resources
California
$17.4M – – –
Citadel Advisors
18
Citadel Advisors
Florida
$16.6M -$94 -4 -0%
BC
19
Boxer Capital
California
$16.4M +$10.5M +446,480 +179%
DCM
20
Driehaus Capital Management
Illinois
$16.2M – – –
Janus Henderson Group
21
Janus Henderson Group
United Kingdom
$15.9M +$15.6M +659,890 +4,721%
FCM
22
Farallon Capital Management
California
$15.7M +$4.7M +200,000 +43%
LGM
23
Logos Global Management
California
$13.5M +$7.64M +325,000 +130%
AAA
24
Affinity Asset Advisors
New York
$12.1M +$2.43M +103,420 +25%
PCH
25
Polar Capital Holdings
United Kingdom
$11.8M – – –
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