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Spyre Therapeutics
SYRE

Overview Fund Activity

77 hedge funds and large institutions have $322M invested in Spyre Therapeutics in 2021 Q3 according to their latest regulatory filings, with 10 funds opening new positions, 24 increasing their positions, 23 reducing their positions, and 10 closing their positions.

Holders
77
Holders Change
-1
Holders Change %
-1.28%
% of All Funds
1.35%
Holding in Top 10
3
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.05%
New
10
Increased
24
Reduced
23
Closed
10
Calls
$90K
Puts
–
Net Calls
+$90K
Net Calls Change
-$122K

Top Buyers

1
PAMS
1
Pictet Asset Management (Switzerland)
Switzerland
$20.1M
2
LCM
2
Laurion Capital Management
New York
$4.82M
3
Adage Capital Partners
3
Adage Capital Partners
Massachusetts
$27.8M
4
BCLSI
4
Bain Capital Life Sciences Investors
Massachusetts
$22.6M
5
SCM
5
Suvretta Capital Management
New York
$17.2M

Top Sellers

1
BC
1
Boxer Capital
California
$0
2
Point72 Asset Management
2
Point72 Asset Management
Connecticut
$0
3
Marshall Wace
3
Marshall Wace
United Kingdom
$2.51M
4
NCM
4
Nantahala Capital Management
Connecticut
$12.1M
5
BlackRock
5
BlackRock
New York
$23.7M
Name Market Value Shares Shares
Change 		Shares
Change %
O
1
OrbiMed
New York
$31.9M 4,015,524 – –
Adage Capital Partners
2
Adage Capital Partners
Massachusetts
$27.8M 3,500,000 +450,419 +15%
BBA
3
Baker Bros. Advisors
New York
$27.1M 3,410,106 – –
BlackRock
4
BlackRock
New York
$23.7M 2,983,895 -119,984 -4%
BCLSI
5
Bain Capital Life Sciences Investors
Massachusetts
$22.6M 2,847,689 +147,689 +5%
PAMS
6
Pictet Asset Management (Switzerland)
Switzerland
$20.1M 2,532,799 +2,532,799 New
SCM
7
Suvretta Capital Management
New York
$17.2M 2,157,727 +63,627 +3%
Vanguard Group
8
Vanguard Group
Pennsylvania
$16.8M 2,108,760 +11,594 +0.6%
ACM
9
Aisling Capital Management
New York
$13.4M 1,691,151 – –
RSCM
10
Rock Springs Capital Management
Maryland
$12.5M 1,577,296 – –
NCM
11
Nantahala Capital Management
Connecticut
$12.1M 1,516,955 -160,081 -10%
Goldman Sachs
12
Goldman Sachs
New York
$9.03M 1,136,050 +4,991 +0.4%
AG
13
Artal Group
Luxembourg
$8.31M 1,045,000 – –
GPP
14
Great Point Partners
Connecticut
$7.16M 900,000 – –
SB
15
Samsara BioCapital
California
$7.03M 883,720 – –
State Street
16
State Street
Massachusetts
$6.1M 766,941 +9,441 +1%
Geode Capital Management
17
Geode Capital Management
Massachusetts
$5.49M 689,997 +12,271 +2%
Dimensional Fund Advisors
18
Dimensional Fund Advisors
Texas
$5.03M 632,833 +28,721 +5%
ACM
19
Altium Capital Management
New York
$4.85M 609,689 – –
LCM
20
Laurion Capital Management
New York
$4.82M 606,638 +606,638 New
Millennium Management
21
Millennium Management
New York
$4.26M 535,222 -7,963 -1%
SCM
22
Sio Capital Management
New York
$3.55M 446,000 +43,347 +11%
Axa
23
Axa
France
$3.5M 439,667 +15,315 +4%
Northern Trust
24
Northern Trust
Illinois
$2.91M 365,703 -2,637 -0.7%
Marshall Wace
25
Marshall Wace
United Kingdom
$2.51M 315,823 -335,580 -52%
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