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Spyre Therapeutics
SYRE

Overview Fund Activity

92 hedge funds and large institutions have $319M invested in Spyre Therapeutics in 2020 Q4 according to their latest regulatory filings, with 10 funds opening new positions, 33 increasing their positions, 29 reducing their positions, and 12 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
92
Holders Change
-2
Holders Change %
-2.13%
% of All Funds
1.63%
Holding in Top 10
3
Holding in Top 10 Change
+1
Holding in Top 10 Change %
+50%
% of All Funds
0.05%
New
10
Increased
33
Reduced
29
Closed
12
Calls
$2K
Puts
$551K
Net Calls
-$549K
Net Calls Change
-$550K

Top Buyers

1
Point72 Asset Management
Point72 Asset Management
Connecticut
+$23M
2
PAMU
Pictet Asset Management (UK)
United Kingdom
+$10.9M
3
Millennium Management
Millennium Management
New York
+$3.19M
4
SCM
Suvretta Capital Management
New York
+$1.81M
5
BlackRock
BlackRock
New York
+$883K

Top Sellers

1
NCM
Nantahala Capital Management
Connecticut
-$9.04M
2
BBA
Baker Bros. Advisors
New York
-$7.63M
3
OM
Opaleye Management
Massachusetts
-$2.66M
4
Renaissance Technologies
Renaissance Technologies
New York
-$2.34M
5
Jacobs Levy Equity Management
Jacobs Levy Equity Management
New Jersey
-$985K
Name Holding Trade Value Shares
Change 		Shares
Change %
O
1
OrbiMed
New York
$31.6M – – –
BBA
2
Baker Bros. Advisors
New York
$26.8M -$7.63M -38,780 -22%
BlackRock
3
BlackRock
New York
$25.5M +$883K +4,488 +4%
Adage Capital Partners
4
Adage Capital Partners
Massachusetts
$23.5M – – –
Point72 Asset Management
5
Point72 Asset Management
Connecticut
$23M +$23M +116,822 New
BCLSI
6
Bain Capital Life Sciences Investors
Massachusetts
$21.2M – – –
PAMU
7
Pictet Asset Management (UK)
United Kingdom
$19.8M +$10.9M +55,335 +122%
NCM
8
Nantahala Capital Management
Connecticut
$15.5M -$9.04M -45,965 -37%
Vanguard Group
9
Vanguard Group
Pennsylvania
$15.4M +$801K +4,071 +6%
ACM
10
Aisling Capital Management
New York
$13.3M – – –
RSCM
11
Rock Springs Capital Management
Maryland
$12.4M -$82.8K -421 -0.7%
Marshall Wace
12
Marshall Wace
United Kingdom
$9.78M +$6.49K +33 +0.1%
AG
13
Artal Group
Luxembourg
$8.22M – – –
SCM
14
Suvretta Capital Management
New York
$5.97M +$1.81M +9,186 +43%
State Street
15
State Street
Massachusetts
$5.72M +$555K +2,819 +11%
Geode Capital Management
16
Geode Capital Management
Massachusetts
$4.46M -$11.2K -57 -0.3%
BC
17
Boxer Capital
California
$4.33M – – –
Dimensional Fund Advisors
18
Dimensional Fund Advisors
Texas
$4.25M +$320K +1,624 +8%
Northern Trust
19
Northern Trust
Illinois
$3.78M +$70.2K +357 +2%
Millennium Management
20
Millennium Management
New York
$3.61M +$3.19M +16,186 +742%
Goldman Sachs
21
Goldman Sachs
New York
$3.42M -$102K -520 -3%
DCM
22
Driehaus Capital Management
Illinois
$3.28M -$46.4K -236 -1%
Axa
23
Axa
France
$3.26M +$857K +4,355 +36%
LPC
24
Lion Point Capital
New York
$2.36M – – –
UOTTAIMCU
25
University of Texas/Texas AM Investment Management Co (UTIMCO)
Texas
$2.2M – – –
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