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Spyre Therapeutics
SYRE

Overview Fund Activity

45 hedge funds and large institutions have $12M invested in Spyre Therapeutics in 2023 Q1 according to their latest regulatory filings, with 3 funds opening new positions, 9 increasing their positions, 9 reducing their positions, and 8 closing their positions.

Holders
45
Holders Change
-6
Holders Change %
-11.76%
% of All Funds
0.72%
Holding in Top 10
1
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.02%
New
3
Increased
9
Reduced
9
Closed
8
Calls
–
Puts
–
Net Calls
–
Net Calls Change
–

Top Buyers

1
Millennium Management
1
Millennium Management
New York
$1.08M
2
CG
2
Carlyle Group
District of Columbia
$69K
3
SFM
3
Sphera Funds Management
Israel
$187K
4
Jane Street
4
Jane Street
New York
$12.4K
5
Renaissance Technologies
5
Renaissance Technologies
New York
$53K

Top Sellers

1
PVI
1
Pura Vida Investments
New York
$0
2
GTC
2
Ghost Tree Capital
New York
$0
3
Susquehanna International Group
3
Susquehanna International Group
Pennsylvania
$0
4
HF
4
HRT Financial
New York
$0
5
Two Sigma Investments
5
Two Sigma Investments
New York
$92.9K
Name Market Value Shares Shares
Change 		Shares
Change %
BCLSI
1
Bain Capital Life Sciences Investors
Massachusetts
$1.55M 5,347,689 – –
NCM
2
Nantahala Capital Management
Connecticut
$1.32M 4,558,012 -53,290 -1%
SCM
3
Suvretta Capital Management
New York
$1.18M 4,059,894 – –
Millennium Management
4
Millennium Management
New York
$1.08M 3,736,483 +605,004 +19%
RSCM
5
Rock Springs Capital Management
Maryland
$990K 3,413,906 – –
BBA
6
Baker Bros. Advisors
New York
$989K 3,410,106 – –
SCM
7
Sio Capital Management
New York
$871K 3,004,959 – –
Vanguard Group
8
Vanguard Group
Pennsylvania
$579K 1,997,597 – –
O
9
OrbiMed
New York
$521K 1,797,221 – –
ACM
10
Aisling Capital Management
New York
$490K 1,691,151 – –
Adage Capital Partners
11
Adage Capital Partners
Massachusetts
$435K 1,500,000 – –
Acadian Asset Management
12
Acadian Asset Management
Massachusetts
$402K 1,391,381 – –
SB
13
Samsara BioCapital
California
$256K 883,720 – –
BlackRock
14
BlackRock
New York
$188K 648,648 +2,694 +0.4%
SFM
15
Sphera Funds Management
Israel
$187K 646,478 +205,641 +47%
Geode Capital Management
16
Geode Capital Management
Massachusetts
$174K 600,455 – –
Two Sigma Investments
17
Two Sigma Investments
New York
$92.9K 320,498 -73,140 -19%
Assenagon Asset Management
18
Assenagon Asset Management
Luxembourg
$92.4K 318,451 – –
UOTTAIMCU
19
University of Texas/Texas AM Investment Management Co (UTIMCO)
Texas
$71K 245,678 – –
CG
20
Carlyle Group
District of Columbia
$69K 240,500 +240,500 New
State Street
21
State Street
Massachusetts
$62.3K 214,989 – –
Two Sigma Advisers
22
Two Sigma Advisers
New York
$61.1K 210,800 -62,000 -23%
Renaissance Technologies
23
Renaissance Technologies
New York
$53K 181,100 +30,000 +20%
BCM
24
Bridgeway Capital Management
Texas
$43.5K 150,000 – –
ECM
25
ExodusPoint Capital Management
New York
$34K 117,479 +12,217 +12%
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