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Spyre Therapeutics
SYRE

Overview Fund Activity

26 hedge funds and large institutions have $24.4M invested in Spyre Therapeutics in 2016 Q4 according to their latest regulatory filings, with 4 funds opening new positions, 7 increasing their positions, 4 reducing their positions, and 6 closing their positions.

Holders
26
Holders Change
-2
Holders Change %
-7.14%
% of All Funds
0.65%
Holding in Top 10
1
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.03%
New
4
Increased
7
Reduced
4
Closed
6
Calls
–
Puts
–
Net Calls
–
Net Calls Change
–

Top Buyers

1
Vanguard Group
1
Vanguard Group
Pennsylvania
$239K
2
SCM
2
Sio Capital Management
New York
$820K
3
LF
3
Lee Financial
Texas
$97K
4
Jennison Associates
4
Jennison Associates
New York
$6.29M
5
Wells Fargo
5
Wells Fargo
California
$75K

Top Sellers

1
RCM
1
RA Capital Management
Massachusetts
$0
2
GTC
2
Ghost Tree Capital
New York
$0
3
Millennium Management
3
Millennium Management
New York
$0
4
Goldman Sachs
4
Goldman Sachs
New York
$45K
5
TG
5
TLP Group
Illinois
$0
Name Market Value Shares Shares
Change 		Shares
Change %
Jennison Associates
1
Jennison Associates
New York
$6.29M 1,445,713 +20,766 +1%
O
2
OrbiMed
New York
$5.92M 1,360,224 – –
UOTTAIMCU
3
University of Texas/Texas AM Investment Management Co (UTIMCO)
Texas
$2.28M 524,929 – –
RSCM
4
Rock Springs Capital Management
Maryland
$2.28M 524,089 – –
BBA
5
Baker Bros. Advisors
New York
$1.76M 404,230 – –
DCM
6
DAFNA Capital Management
California
$1.52M 350,392 – –
VMI
7
VHCP Management II
New York
$1.52M 350,133 – –
SCM
8
Sio Capital Management
New York
$820K 188,485 +34,153 +22%
Alyeska Investment Group
9
Alyeska Investment Group
Illinois
$521K 119,707 +10,062 +9%
PA
10
Perceptive Advisors
New York
$451K 103,585 – –
Norges Bank
11
Norges Bank
Norway
$275K 63,200 – –
Vanguard Group
12
Vanguard Group
Pennsylvania
$239K 54,958 +40,322 +275%
Geode Capital Management
13
Geode Capital Management
Massachusetts
$101K 23,311 +4,092 +21%
LF
14
Lee Financial
Texas
$97K 22,408 +22,408 New
Wells Fargo
15
Wells Fargo
California
$75K 17,281 +14,481 +517%
BFA
16
BlackRock Fund Advisors
California
$60K 13,810 +650 +5%
SIM
17
Spark Investment Management
New York
$52K 12,000 +12,000 New
Goldman Sachs
18
Goldman Sachs
New York
$45K 10,386 -22,640 -69%
VM
19
VHCP Management
New York
$26K 6,000 – –
Morgan Stanley
20
Morgan Stanley
New York
$12K 2,732 -1,058 -28%
IA
21
IFP Advisors
Florida
$12K 2,860 – –
BIM
22
BlackRock Investment Management
Delaware
$4K 821 – –
UBS Group
23
UBS Group
Switzerland
$3K 800 -16,571 -95%
Acadian Asset Management
24
Acadian Asset Management
Massachusetts
$2K 484 +484 New
TRCT
25
Tower Research Capital (TRC)
New York
$1K 200 -503 -72%
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