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Spyre Therapeutics
SYRE

Overview Fund Activity

54 hedge funds and large institutions have $601M invested in Spyre Therapeutics in 2023 Q4 according to their latest regulatory filings, with 29 funds opening new positions, 16 increasing their positions, 5 reducing their positions, and 4 closing their positions.

Holders
54
Holders Change
+25
Holders Change %
+86.21%
% of All Funds
0.79%
Holding in Top 10
3
Holding in Top 10 Change
+2
Holding in Top 10 Change %
+200%
% of All Funds
0.04%
New
29
Increased
16
Reduced
5
Closed
4
Calls
$44K
Puts
–
Net Calls
+$44K
Net Calls Change
+$11K

Top Buyers

1
Fidelity Investments
1
Fidelity Investments
Massachusetts
$79.7M
2
PA
2
Perceptive Advisors
New York
$56.1M
3
RI
3
RTW Investments
New York
$48M
4
VA
4
VR Adviser
New York
$51.1M
5
DTC
5
Deep Track Capital
Connecticut
$42M

Top Sellers

1
RSCM
1
Rock Springs Capital Management
Maryland
$0
2
LGM
2
Logos Global Management
California
$3.23M
3
ACM
3
Aisling Capital Management
New York
$0
4
DCM
4
Driehaus Capital Management
Illinois
$16.6M
5
YF
5
Yu Fan
$0
Name Market Value Shares Shares
Change 		Shares
Change %
Fidelity Investments
1
Fidelity Investments
Massachusetts
$79.7M 3,785,877 +3,785,877 New
PA
2
Perceptive Advisors
New York
$56.1M 2,606,679 +2,525,563 +3,114%
VA
3
VR Adviser
New York
$51.1M 2,372,714 +2,077,680 +704%
RI
4
RTW Investments
New York
$48M 2,232,760 +2,232,760 New
DTC
5
Deep Track Capital
Connecticut
$42M 1,952,760 +1,952,760 New
CC
6
Commodore Capital
New York
$40.5M 1,884,084 +1,767,760 +1,520%
ACA
7
Avoro Capital Advisors
New York
$39.6M 1,839,138 +1,827,680 +15,951%
Adage Capital Partners
8
Adage Capital Partners
Massachusetts
$21.5M 1,000,000 +1,000,000 New
CAM
9
Cormorant Asset Management
Massachusetts
$20.2M 937,080 +937,080 New
EC
10
EcoR1 Capital
California
$19.1M 887,076 +687,080 +344%
DCM
11
Driehaus Capital Management
Illinois
$16.6M 771,902 -28,951 -4%
Franklin Resources
12
Franklin Resources
California
$14.8M 687,090 +687,090 New
BI
13
BVF Inc
California
$14.8M 687,080 +687,080 New
Wellington Management Group
14
Wellington Management Group
Massachusetts
$13.7M 635,455 +335,526 +112%
UONDDL
15
University of Notre Dame du Lac
Indiana
$12.4M 577,616 +577,616 New
HS
16
HighVista Strategies
Massachusetts
$12.4M 577,616 +577,616 New
Citadel Advisors
17
Citadel Advisors
Florida
$12.4M 576,711 +479,658 +494%
AAA
18
Affinity Asset Advisors
New York
$11.1M 517,554 +275,257 +114%
B
19
Braidwell
Connecticut
$11.1M 515,000 +515,000 New
GEM
20
Global Endowment Management
North Carolina
$11M 513,436 +513,436 New
PCH
21
Polar Capital Holdings
United Kingdom
$10.8M 500,000 +200,000 +67%
SC
22
Stempoint Capital
New York
$8.15M 378,766 +378,766 New
FFM
23
Fairmount Funds Management
Pennsylvania
$8.14M 378,421 – –
BC
24
Boxer Capital
California
$5.38M 250,000 +250,000 New
SCM
25
Suvretta Capital Management
New York
$3.49M 162,395 – –
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