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Spyre Therapeutics

60 hedge funds and large institutions have $123M invested in Spyre Therapeutics in 2018 Q4 according to their latest regulatory filings, with 10 funds opening new positions, 18 increasing their positions, 16 reducing their positions, and 9 closing their positions.

New
Increased
Maintained
Reduced
Closed

100% more funds holding in top 10

Funds holding in top 10: 12 (+1)

13% more repeat investments, than reductions

Existing positions increased: 18 | Existing positions reduced: 16

11% more first-time investments, than exits

New positions opened: 10 | Existing positions closed: 9

2% more funds holding

Funds holding: 5960 (+1)

0.08% more ownership

Funds ownership: 2.65%2.74% (+0.08%)

12% less capital invested

Capital invested by funds: $140M → $123M (-$17.4M)

Holders
60
Holders Change
+1
Holders Change %
+1.69%
% of All Funds
1.34%
Holding in Top 10
2
Holding in Top 10 Change
+1
Holding in Top 10 Change %
+100%
% of All Funds
0.04%
New
10
Increased
18
Reduced
16
Closed
9
Calls
Puts
Net Calls
Net Calls Change
Name Holding Trade Value Shares
Change
Change in
Stake
NCM
1
Nantahala Capital Management
Connecticut
$18.9M
O
2
OrbiMed
New York
$16.2M
BBA
3
Baker Bros. Advisors
New York
$12.8M +$2.76M +13,029 +23%
Adage Capital Partners
4
Adage Capital Partners
Massachusetts
$10.9M +$4.61M +21,716 +59%
Jennison Associates
5
Jennison Associates
New York
$10.1M -$1.53M -7,224 -12%
BlackRock
6
BlackRock
New York
$9.77M +$2.33M +11,002 +27%
ACM
7
Aisling Capital Management
New York
$6.51M +$7.37M +34,745 New
Vanguard Group
8
Vanguard Group
Pennsylvania
$5.84M +$231K +1,087 +4%
RSCM
9
Rock Springs Capital Management
Maryland
$4.87M
SFM
10
Sphera Funds Management
Israel
$4.49M -$451K -2,124 -8%
Renaissance Technologies
11
Renaissance Technologies
New York
$3.42M -$91.2K -430 -2%
UOTTAIMCU
12
University of Texas/Texas AM Investment Management Co (UTIMCO)
Texas
$2.51M
RWM
13
Ritholtz Wealth Management
New York
$2.18M +$2.47M +11,621 New
Dimensional Fund Advisors
14
Dimensional Fund Advisors
Texas
$2.14M +$1.02M +4,796 +72%
State Street
15
State Street
Massachusetts
$1.84M -$20.8K -98 -1%
Northern Trust
16
Northern Trust
Illinois
$1.37M +$7.85K +37 +0.5%
Geode Capital Management
17
Geode Capital Management
Massachusetts
$1.22M +$70.6K +333 +5%
Man Group
18
Man Group
United Kingdom
$932K -$1.49M -7,001 -58%
FI
19
Fosun International
China
$778K +$824K +3,886 New
BCM
20
Bridgeway Capital Management
Texas
$768K
Squarepoint
21
Squarepoint
New York
$445K -$102K -482 -17%
Bank of New York Mellon
22
Bank of New York Mellon
New York
$371K +$43.7K +206 +12%
UBS Group
23
UBS Group
Switzerland
$319K -$89.5K -422 -20%
Charles Schwab
24
Charles Schwab
California
$309K +$92.1K +434 +36%
Wells Fargo
25
Wells Fargo
California
$293K +$174K +819 +110%

SYRE Hedge Fund Activity: Q4 2018 in Review

60 of the 4,489 institutional investors tracked by Wall St. Rank reported a position in Spyre Therapeutics (SYRE) for Q4 2018, worth a combined $123M — down 12% from $140M a quarter earlier.

Buyers outnumbered sellers: 10 funds opened new SYRE positions and 9 closed out — a net gain of 1 holder — while 18 added to existing stakes and 16 trimmed.

The largest buyer was Adage Capital Partners, adding an estimated $4.61M. The largest seller was Point72 Asset Management, exiting entirely with an estimated $2.54M sold.

  • 60 institutional investors held Spyre Therapeutics (SYRE) as of Q4 2018, up from 59 in Q3 2018.
  • Funds reported $123M of Spyre Therapeutics stock for Q4 2018, down 12% quarter-over-quarter.
  • 10 funds opened new Spyre Therapeutics positions in Q4 2018 and 9 closed out, a net change of +1 holder.
  • The largest Spyre Therapeutics buyer in Q4 2018 was Adage Capital Partners, an estimated $4.61M added.
  • The largest Spyre Therapeutics seller in Q4 2018 was Point72 Asset Management, an estimated $2.54M sold.

Based on aggregated 13F filings for Q4 2018.