SYRE icon

Spyre Therapeutics
SYRE

Overview Fund Activity

51 hedge funds and large institutions have $19.2M invested in Spyre Therapeutics in 2022 Q4 according to their latest regulatory filings, with 9 funds opening new positions, 12 increasing their positions, 11 reducing their positions, and 13 closing their positions.

Holders
51
Holders Change
-4
Holders Change %
-7.27%
% of All Funds
0.82%
Holding in Top 10
1
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.02%
New
9
Increased
12
Reduced
11
Closed
13
Calls
$11K
Puts
–
Net Calls
+$11K
Net Calls Change
+$3K

Top Buyers

1
Millennium Management
1
Millennium Management
New York
$1.41M
2
PVI
2
Pura Vida Investments
New York
$472K
3
Acadian Asset Management
3
Acadian Asset Management
Massachusetts
$625K
4
NCM
4
Nantahala Capital Management
Connecticut
$2.07M
5
SFM
5
Sphera Funds Management
Israel
$198K

Top Sellers

1
PAMS
1
Pictet Asset Management (Switzerland)
Switzerland
$0
2
GPP
2
Great Point Partners
Connecticut
$0
3
SCM
3
Sio Capital Management
New York
$1.35M
4
Goldman Sachs
4
Goldman Sachs
New York
$0
5
BlackRock
5
BlackRock
New York
$291K
Name Market Value Shares Shares
Change 		Shares
Change %
BCLSI
1
Bain Capital Life Sciences Investors
Massachusetts
$2.41M 5,347,689 – –
NCM
2
Nantahala Capital Management
Connecticut
$2.07M 4,611,302 +900,524 +24%
SCM
3
Suvretta Capital Management
New York
$1.83M 4,059,894 – –
RSCM
4
Rock Springs Capital Management
Maryland
$1.54M 3,413,906 – –
BBA
5
Baker Bros. Advisors
New York
$1.53M 3,410,106 – –
Millennium Management
6
Millennium Management
New York
$1.41M 3,131,479 +2,316,807 +284%
SCM
7
Sio Capital Management
New York
$1.35M 3,004,959 -1,663,577 -36%
Vanguard Group
8
Vanguard Group
Pennsylvania
$899K 1,997,597 +110,201 +6%
O
9
OrbiMed
New York
$809K 1,797,221 – –
ACM
10
Aisling Capital Management
New York
$761K 1,691,151 – –
Adage Capital Partners
11
Adage Capital Partners
Massachusetts
$675K 1,500,000 – –
Acadian Asset Management
12
Acadian Asset Management
Massachusetts
$625K 1,391,381 +922,823 +197%
PVI
13
Pura Vida Investments
New York
$472K 1,048,697 +1,048,697 New
SB
14
Samsara BioCapital
California
$398K 883,720 – –
GTC
15
Ghost Tree Capital
New York
$360K 800,000 -200,000 -20%
BlackRock
16
BlackRock
New York
$291K 645,954 -386,711 -37%
Geode Capital Management
17
Geode Capital Management
Massachusetts
$270K 600,455 +206,435 +52%
SFM
18
Sphera Funds Management
Israel
$198K 440,837 +440,837 New
Two Sigma Investments
19
Two Sigma Investments
New York
$177K 393,638 +290,049 +280%
Assenagon Asset Management
20
Assenagon Asset Management
Luxembourg
$143K 318,451 – –
Two Sigma Advisers
21
Two Sigma Advisers
New York
$123K 272,800 -137,100 -33%
UOTTAIMCU
22
University of Texas/Texas AM Investment Management Co (UTIMCO)
Texas
$111K 245,678 – –
A
23
Abingworth
United Kingdom
$108K 240,500 – –
State Street
24
State Street
Massachusetts
$96.7K 214,989 +56,000 +35%
Renaissance Technologies
25
Renaissance Technologies
New York
$68K 151,100 -98,700 -40%
1
2 3