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Spyre Therapeutics
SYRE

Overview Fund Activity

66 hedge funds and large institutions have $25.4M invested in Spyre Therapeutics in 2022 Q2 according to their latest regulatory filings, with 13 funds opening new positions, 21 increasing their positions, 17 reducing their positions, and 29 closing their positions.

Holders
66
Holders Change
-18
Holders Change %
-21.43%
% of All Funds
1.12%
Holding in Top 10
1
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-50%
% of All Funds
0.02%
New
13
Increased
21
Reduced
17
Closed
29
Calls
$23K
Puts
–
Net Calls
+$23K
Net Calls Change
+$20K

Top Buyers

1
SCM
1
Sio Capital Management
New York
$2.36M
2
GPP
2
Great Point Partners
Connecticut
$1.26M
3
BCLSI
3
Bain Capital Life Sciences Investors
Massachusetts
$2.7M
4
PAMS
4
Pictet Asset Management (Switzerland)
Switzerland
$2.47M
5
Adage Capital Partners
5
Adage Capital Partners
Massachusetts
$758K

Top Sellers

1
LCM
1
Laurion Capital Management
New York
$0
2
Deutsche Bank
2
Deutsche Bank
Germany
$0
3
Jacobs Levy Equity Management
3
Jacobs Levy Equity Management
New Jersey
$0
4
BlackRock
4
BlackRock
New York
$540K
5
Nuveen Asset Management
5
Nuveen Asset Management
Illinois
$0
Name Market Value Shares Shares
Change 		Shares
Change %
BCLSI
1
Bain Capital Life Sciences Investors
Massachusetts
$2.7M 5,347,689 +2,500,000 +88%
PAMS
2
Pictet Asset Management (Switzerland)
Switzerland
$2.47M 4,890,502 +2,338,068 +92%
SCM
3
Sio Capital Management
New York
$2.36M 4,668,536 +3,797,435 +436%
SCM
4
Suvretta Capital Management
New York
$2.05M 4,059,894 – –
NCM
5
Nantahala Capital Management
Connecticut
$1.96M 3,877,311 +676,718 +21%
BBA
6
Baker Bros. Advisors
New York
$1.72M 3,410,106 – –
RSCM
7
Rock Springs Capital Management
Maryland
$1.55M 3,072,034 +1,260,609 +70%
LPC
8
Lion Point Capital
New York
$1.43M 300,000 – –
GPP
9
Great Point Partners
Connecticut
$1.26M 2,500,000 +2,500,000 New
Vanguard Group
10
Vanguard Group
Pennsylvania
$984K 1,948,009 -169,314 -8%
ACM
11
Aisling Capital Management
New York
$854K 1,691,151 – –
Adage Capital Partners
12
Adage Capital Partners
Massachusetts
$758K 1,500,000 +1,500,000 New
Goldman Sachs
13
Goldman Sachs
New York
$600K 1,187,293 +62,504 +6%
BlackRock
14
BlackRock
New York
$540K 1,069,602 -1,852,208 -63%
GTC
15
Ghost Tree Capital
New York
$467K 925,000 +238,401 +35%
SB
16
Samsara BioCapital
California
$446K 883,720 – –
Assenagon Asset Management
17
Assenagon Asset Management
Luxembourg
$325K 642,835 +119,693 +23%
Renaissance Technologies
18
Renaissance Technologies
New York
$294K 582,444 +430,576 +284%
Millennium Management
19
Millennium Management
New York
$264K 521,915 +98,001 +23%
Dimensional Fund Advisors
20
Dimensional Fund Advisors
Texas
$255K 506,326 -174,638 -26%
D.E. Shaw & Co
21
D.E. Shaw & Co
New York
$241K 476,404 +22,311 +5%
Acadian Asset Management
22
Acadian Asset Management
Massachusetts
$208K 413,387 +263,988 +177%
Geode Capital Management
23
Geode Capital Management
Massachusetts
$199K 394,020 -298,201 -43%
Two Sigma Investments
24
Two Sigma Investments
New York
$160K 315,840 +99,239 +46%
Morgan Stanley
25
Morgan Stanley
New York
$148K 293,834 +112,133 +62%
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