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Spyre Therapeutics
SYRE

Overview Fund Activity

71 hedge funds and large institutions have $159M invested in Spyre Therapeutics in 2019 Q1 according to their latest regulatory filings, with 17 funds opening new positions, 25 increasing their positions, 12 reducing their positions, and 6 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
71
Holders Change
+11
Holders Change %
+18.33%
% of All Funds
1.54%
Holding in Top 10
4
Holding in Top 10 Change
+2
Holding in Top 10 Change %
+100%
% of All Funds
0.09%
New
17
Increased
25
Reduced
12
Closed
6
Calls
–
Puts
–
Net Calls
–
Net Calls Change
–

Top Buyers

1
DM
Deerfield Management
New York
+$4.03M
2
Goldman Sachs
Goldman Sachs
New York
+$3.11M
3
Marshall Wace
Marshall Wace
United Kingdom
+$3.03M
4
SFM
Sphera Funds Management
Israel
+$3.02M
5
ACM
Aisling Capital Management
New York
+$2.84M

Top Sellers

1
Jennison Associates
Jennison Associates
New York
-$4.63M
2
Man Group
Man Group
United Kingdom
-$276K
3
Squarepoint
Squarepoint
New York
-$167K
4
Morgan Stanley
Morgan Stanley
New York
-$147K
5
TI
Trexquant Investment
Connecticut
-$116K
Name Holding Trade Value Shares
Change 		Shares
Change %
NCM
1
Nantahala Capital Management
Connecticut
$21.4M +$1.01M +5,000 +5%
O
2
OrbiMed
New York
$17.4M – – –
BBA
3
Baker Bros. Advisors
New York
$13.8M – – –
BlackRock
4
BlackRock
New York
$12M +$1.5M +7,454 +14%
Adage Capital Partners
5
Adage Capital Partners
Massachusetts
$11.8M +$80.5K +400 +0.7%
ACM
6
Aisling Capital Management
New York
$9.83M +$2.84M +14,091 +41%
Vanguard Group
7
Vanguard Group
Pennsylvania
$8.94M +$2.66M +13,200 +42%
SFM
8
Sphera Funds Management
Israel
$7.85M +$3.02M +15,000 +63%
RSCM
9
Rock Springs Capital Management
Maryland
$6.44M +$1.21M +6,000 +23%
Jennison Associates
10
Jennison Associates
New York
$6.25M -$4.63M -23,028 -43%
DM
11
Deerfield Management
New York
$4.03M +$4.03M +20,002 New
Renaissance Technologies
12
Renaissance Technologies
New York
$3.65M -$21.7K -108 -0.6%
Dimensional Fund Advisors
13
Dimensional Fund Advisors
Texas
$3.63M +$1.32M +6,575 +57%
Goldman Sachs
14
Goldman Sachs
New York
$3.25M +$3.11M +15,430 +2,182%
Marshall Wace
15
Marshall Wace
United Kingdom
$3.03M +$3.03M +15,036 New
UOTTAIMCU
16
University of Texas/Texas AM Investment Management Co (UTIMCO)
Texas
$2.7M – – –
RWM
17
Ritholtz Wealth Management
New York
$2.34M – – –
CH
18
CVI Holdings
Delaware
$2.19M +$2.19M +10,862 New
State Street
19
State Street
Massachusetts
$1.97M -$8.25K -41 -0.4%
Geode Capital Management
20
Geode Capital Management
Massachusetts
$1.94M +$629K +3,125 +48%
A
21
Abingworth
United Kingdom
$1.93M +$1.93M +9,620 New
Northern Trust
22
Northern Trust
Illinois
$1.74M +$267K +1,328 +18%
FI
23
Fosun International
China
$1.4M +$628K +3,160 +81%
Citadel Advisors
24
Citadel Advisors
Florida
$960K +$960K +4,768 New
BCM
25
Bridgeway Capital Management
Texas
$825K – – –
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