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Spyre Therapeutics
SYRE

Overview Fund Activity

84 hedge funds and large institutions have $95.4M invested in Spyre Therapeutics in 2022 Q1 according to their latest regulatory filings, with 10 funds opening new positions, 28 increasing their positions, 26 reducing their positions, and 12 closing their positions.

Holders
84
Holders Change
-2
Holders Change %
-2.33%
% of All Funds
1.33%
Holding in Top 10
2
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.03%
New
10
Increased
28
Reduced
26
Closed
12
Calls
$3K
Puts
–
Net Calls
+$3K
Net Calls Change
-$12K

Top Buyers

1
SCM
1
Suvretta Capital Management
New York
$9.34M
2
GTC
2
Ghost Tree Capital
New York
$1.58M
3
Deutsche Bank
3
Deutsche Bank
Germany
$1.19M
4
NCM
4
Nantahala Capital Management
Connecticut
$7.36M
5
SCM
5
Sio Capital Management
New York
$2M

Top Sellers

1
AG
1
Artal Group
Luxembourg
$0
2
Adage Capital Partners
2
Adage Capital Partners
Massachusetts
$0
3
GPP
3
Great Point Partners
Connecticut
$0
4
Axa
4
Axa
France
$0
5
ACM
5
Altium Capital Management
New York
$0
Name Market Value Shares Shares
Change 		Shares
Change %
SCM
1
Suvretta Capital Management
New York
$9.34M 4,059,894 +1,488,894 +58%
BBA
2
Baker Bros. Advisors
New York
$7.84M 3,410,106 – –
NCM
3
Nantahala Capital Management
Connecticut
$7.36M 3,200,593 +387,033 +14%
O
4
OrbiMed
New York
$6.8M 2,956,124 – –
BlackRock
5
BlackRock
New York
$6.72M 2,921,810 -76,669 -3%
BCLSI
6
Bain Capital Life Sciences Investors
Massachusetts
$6.55M 2,847,689 – –
PAMS
7
Pictet Asset Management (Switzerland)
Switzerland
$5.87M 2,552,434 +84,305 +3%
Vanguard Group
8
Vanguard Group
Pennsylvania
$4.87M 2,117,323 -3,302 -0.2%
RSCM
9
Rock Springs Capital Management
Maryland
$4.17M 1,811,425 +234,129 +15%
ACM
10
Aisling Capital Management
New York
$3.89M 1,691,151 – –
LCM
11
Laurion Capital Management
New York
$3.62M 1,575,638 +125,000 +9%
Goldman Sachs
12
Goldman Sachs
New York
$2.59M 1,124,789 -9,562 -0.8%
SB
13
Samsara BioCapital
California
$2.03M 883,720 – –
SCM
14
Sio Capital Management
New York
$2M 871,101 +372,601 +75%
State Street
15
State Street
Massachusetts
$1.81M 787,048 +29,007 +4%
Geode Capital Management
16
Geode Capital Management
Massachusetts
$1.59M 692,221 +6,476 +0.9%
GTC
17
Ghost Tree Capital
New York
$1.58M 686,599 +686,599 New
Dimensional Fund Advisors
18
Dimensional Fund Advisors
Texas
$1.57M 680,964 -9,609 -1%
Assenagon Asset Management
19
Assenagon Asset Management
Luxembourg
$1.2M 523,142 +106,968 +26%
Deutsche Bank
20
Deutsche Bank
Germany
$1.19M 515,133 +490,598 +2,000%
D.E. Shaw & Co
21
D.E. Shaw & Co
New York
$1.05M 454,093 +226,585 +100%
Jacobs Levy Equity Management
22
Jacobs Levy Equity Management
New Jersey
$1M 436,183 +292,090 +203%
Millennium Management
23
Millennium Management
New York
$975K 423,914 +233,432 +123%
Northern Trust
24
Northern Trust
Illinois
$768K 333,741 -15,947 -5%
LPC
25
Lion Point Capital
New York
$690K 300,000 – –
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