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Spyre Therapeutics
SYRE

Overview Fund Activity

131 hedge funds and large institutions have $1.39B invested in Spyre Therapeutics in 2024 Q4 according to their latest regulatory filings, with 34 funds opening new positions, 63 increasing their positions, 20 reducing their positions, and 21 closing their positions.

Holders
131
Holders Change
+12
Holders Change %
+10.08%
% of All Funds
1.74%
Holding in Top 10
4
Holding in Top 10 Change
+1
Holding in Top 10 Change %
+33.33%
% of All Funds
0.05%
New
34
Increased
63
Reduced
20
Closed
21
Calls
$161K
Puts
$79K
Net Calls
+$82K
Net Calls Change
+$102K

Top Buyers

1
DCM
1
Driehaus Capital Management
Illinois
$65.3M
2
Fidelity Investments
2
Fidelity Investments
Massachusetts
$205M
3
JFG
3
Jefferies Financial Group
New York
$28.3M
4
BlackRock
4
BlackRock
New York
$79.1M
5
Goldman Sachs
5
Goldman Sachs
New York
$17.4M

Top Sellers

1
Assenagon Asset Management
1
Assenagon Asset Management
Luxembourg
$527K
2
BC
2
Boxer Capital
California
$0
3
DTC
3
Deep Track Capital
Connecticut
$5.1M
4
ACA
4
Avoro Capital Advisors
New York
$0
5
Walleye Capital
5
Walleye Capital
New York
$0
Name Market Value Shares Shares
Change 		Shares
Change %
Fidelity Investments
1
Fidelity Investments
Massachusetts
$205M 8,801,266 +1,177,385 +15%
FFM
2
Fairmount Funds Management
Pennsylvania
$93.5M 4,018,101 – –
RI
3
RTW Investments
New York
$84.3M 3,621,996 +363,636 +11%
BlackRock
4
BlackRock
New York
$79.1M 3,399,591 +736,444 +28%
Vanguard Group
5
Vanguard Group
Pennsylvania
$66.3M 2,846,473 +330,553 +13%
DCM
6
Driehaus Capital Management
Illinois
$65.3M 2,803,655 +2,116,575 +308%
VA
7
VR Adviser
New York
$62.5M 2,685,448 – –
B
8
Braidwell
Connecticut
$60M 2,578,404 +388,568 +18%
PA
9
Perceptive Advisors
New York
$59.9M 2,574,723 -297,824 -10%
CC
10
Commodore Capital
New York
$46.3M 1,988,084 – –
State Street
11
State Street
Massachusetts
$39.1M 1,680,936 +139,381 +9%
Wellington Management Group
12
Wellington Management Group
Massachusetts
$37.4M 1,604,508 +97,308 +6%
PBA
13
Paradigm Biocapital Advisors
New York
$35.6M 1,527,205 +259,624 +20%
Janus Henderson Group
14
Janus Henderson Group
United Kingdom
$33.9M 1,456,740 +336,209 +30%
JFG
15
Jefferies Financial Group
New York
$28.3M 1,216,954 +762,147 +168%
Pictet Asset Management
16
Pictet Asset Management
Switzerland
$25.4M 1,092,124 +266,418 +32%
Citadel Advisors
17
Citadel Advisors
Florida
$25.1M 1,079,307 +371,721 +53%
Adage Capital Partners
18
Adage Capital Partners
Massachusetts
$24M 1,030,000 -25,000 -2%
Geode Capital Management
19
Geode Capital Management
Massachusetts
$22.5M 966,129 +75,081 +8%
AAA
20
Affinity Asset Advisors
New York
$19.2M 824,328 +325,908 +65%
Franklin Resources
21
Franklin Resources
California
$17.7M 760,642 -24 -0%
PCH
22
Polar Capital Holdings
United Kingdom
$17.5M 750,000 +250,000 +50%
Goldman Sachs
23
Goldman Sachs
New York
$17.4M 747,552 +578,238 +342%
EA
24
Emerald Advisers
Pennsylvania
$12.7M 546,791 +254,222 +87%
T. Rowe Price Associates
25
T. Rowe Price Associates
Maryland
$11.8M 506,450 +77,323 +18%
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