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Spyre Therapeutics
SYRE

Overview Fund Activity

44 hedge funds and large institutions have $31.9M invested in Spyre Therapeutics in 2023 Q2 according to their latest regulatory filings, with 14 funds opening new positions, 5 increasing their positions, 9 reducing their positions, and 15 closing their positions.

Holders
44
Holders Change
-1
Holders Change %
-2.22%
% of All Funds
0.69%
Holding in Top 10
2
Holding in Top 10 Change
+1
Holding in Top 10 Change %
+100%
% of All Funds
0.03%
New
14
Increased
5
Reduced
9
Closed
15
Calls
–
Puts
$1K
Net Calls
-$1K
Net Calls Change
-$1K

Top Buyers

1
FFM
1
Fairmount Funds Management
Pennsylvania
$4.26M
2
Wellington Management Group
2
Wellington Management Group
Massachusetts
$3.97M
3
VA
3
VR Adviser
New York
$2.86M
4
EC
4
EcoR1 Capital
California
$2.25M
5
AAA
5
Affinity Asset Advisors
New York
$2.21M

Top Sellers

1
BCLSI
1
Bain Capital Life Sciences Investors
Massachusetts
$0
2
SCM
2
Sio Capital Management
New York
$0
3
Vanguard Group
3
Vanguard Group
Pennsylvania
$292K
4
Millennium Management
4
Millennium Management
New York
$1.11M
5
O
5
OrbiMed
New York
$0
Name Market Value Shares Shares
Change 		Shares
Change %
FFM
1
Fairmount Funds Management
Pennsylvania
$4.26M 9,460,540 +9,460,540 New
Wellington Management Group
2
Wellington Management Group
Massachusetts
$3.97M 8,819,168 +8,819,168 New
VA
3
VR Adviser
New York
$2.86M 6,343,221 +6,343,221 New
EC
4
EcoR1 Capital
California
$2.25M 5,000,000 +5,000,000 New
AAA
5
Affinity Asset Advisors
New York
$2.21M 4,900,000 +4,900,000 New
DCM
6
Driehaus Capital Management
Illinois
$2.09M 4,643,357 +4,643,357 New
NCM
7
Nantahala Capital Management
Connecticut
$1.85M 4,101,193 -456,819 -10%
SCM
8
Suvretta Capital Management
New York
$1.83M 4,059,894 – –
RSCM
9
Rock Springs Capital Management
Maryland
$1.54M 3,413,906 – –
BBA
10
Baker Bros. Advisors
New York
$1.54M 3,410,106 – –
LGM
11
Logos Global Management
California
$1.42M 3,142,880 +3,142,880 New
CC
12
Commodore Capital
New York
$1.31M 2,908,100 +2,908,100 New
Millennium Management
13
Millennium Management
New York
$1.11M 2,453,221 -1,283,262 -34%
ACM
14
Aisling Capital Management
New York
$762K 1,691,151 – –
Acadian Asset Management
15
Acadian Asset Management
Massachusetts
$625K 1,391,381 – –
SB
16
Samsara BioCapital
California
$398K 883,720 – –
Vanguard Group
17
Vanguard Group
Pennsylvania
$292K 648,053 -1,349,544 -68%
Geode Capital Management
18
Geode Capital Management
Massachusetts
$271K 600,455 – –
Goldman Sachs
19
Goldman Sachs
New York
$252K 558,650 +558,650 New
BlackRock
20
BlackRock
New York
$238K 528,897 -119,751 -18%
Renaissance Technologies
21
Renaissance Technologies
New York
$177K 393,000 +211,900 +117%
ACA
22
Avoro Capital Advisors
New York
$129K 286,459 +286,459 New
UOTTAIMCU
23
University of Texas/Texas AM Investment Management Co (UTIMCO)
Texas
$111K 245,678 – –
CG
24
Carlyle Group
District of Columbia
$108K 240,500 – –
State Street
25
State Street
Massachusetts
$87.9K 195,089 -19,900 -9%
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