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Spyre Therapeutics
SYRE

Overview Fund Activity

86 hedge funds and large institutions have $189M invested in Spyre Therapeutics in 2021 Q4 according to their latest regulatory filings, with 19 funds opening new positions, 26 increasing their positions, 22 reducing their positions, and 9 closing their positions.

Holders
86
Holders Change
+9
Holders Change %
+11.69%
% of All Funds
1.33%
Holding in Top 10
2
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-33.33%
% of All Funds
0.03%
New
19
Increased
26
Reduced
22
Closed
9
Calls
$263K
Puts
$248K
Net Calls
+$15K
Net Calls Change
-$75K

Top Buyers

1
NCM
1
Nantahala Capital Management
Connecticut
$13.4M
2
LCM
2
Laurion Capital Management
New York
$6.89M
3
SCM
3
Suvretta Capital Management
New York
$12.2M
4
D.E. Shaw & Co
4
D.E. Shaw & Co
New York
$1.08M
5
CAM
5
ClariVest Asset Management
California
$832K

Top Sellers

1
Adage Capital Partners
1
Adage Capital Partners
Massachusetts
$4.75M
2
O
2
OrbiMed
New York
$14M
3
Millennium Management
3
Millennium Management
New York
$905K
4
ACM
4
Altium Capital Management
New York
$1.4M
5
Marshall Wace
5
Marshall Wace
United Kingdom
$197K
Name Market Value Shares Shares
Change 		Shares
Change %
BBA
1
Baker Bros. Advisors
New York
$16.2M 3,410,106 – –
BlackRock
2
BlackRock
New York
$14.2M 2,998,479 +14,584 +0.5%
O
3
OrbiMed
New York
$14M 2,956,124 -1,059,400 -26%
BCLSI
4
Bain Capital Life Sciences Investors
Massachusetts
$13.5M 2,847,689 – –
NCM
5
Nantahala Capital Management
Connecticut
$13.4M 2,813,560 +1,296,605 +85%
SCM
6
Suvretta Capital Management
New York
$12.2M 2,571,000 +413,273 +19%
PAMS
7
Pictet Asset Management (Switzerland)
Switzerland
$11.7M 2,468,129 -64,670 -3%
Vanguard Group
8
Vanguard Group
Pennsylvania
$10.1M 2,120,625 +11,865 +0.6%
ACM
9
Aisling Capital Management
New York
$8.03M 1,691,151 – –
RSCM
10
Rock Springs Capital Management
Maryland
$7.49M 1,577,296 – –
LCM
11
Laurion Capital Management
New York
$6.89M 1,450,638 +844,000 +139%
Goldman Sachs
12
Goldman Sachs
New York
$5.39M 1,134,351 -1,699 -0.1%
AG
13
Artal Group
Luxembourg
$4.96M 1,045,000 – –
Adage Capital Partners
14
Adage Capital Partners
Massachusetts
$4.75M 1,000,000 -2,500,000 -71%
GPP
15
Great Point Partners
Connecticut
$4.32M 910,251 +10,251 +1%
SB
16
Samsara BioCapital
California
$4.2M 883,720 – –
State Street
17
State Street
Massachusetts
$3.6M 758,041 -8,900 -1%
Dimensional Fund Advisors
18
Dimensional Fund Advisors
Texas
$3.28M 690,573 +57,740 +9%
Geode Capital Management
19
Geode Capital Management
Massachusetts
$3.26M 685,745 -4,252 -0.6%
SCM
20
Sio Capital Management
New York
$2.37M 498,500 +52,500 +12%
Axa
21
Axa
France
$2.11M 444,931 +5,264 +1%
Assenagon Asset Management
22
Assenagon Asset Management
Luxembourg
$1.98M 416,174 +149,108 +56%
Northern Trust
23
Northern Trust
Illinois
$1.66M 349,688 -16,015 -4%
LPC
24
Lion Point Capital
New York
$1.43M 300,000 – –
ACM
25
Altium Capital Management
New York
$1.4M 293,764 -315,925 -52%
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