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Spyre Therapeutics
SYRE

Overview Fund Activity

84 hedge funds and large institutions have $328M invested in Spyre Therapeutics in 2021 Q1 according to their latest regulatory filings, with 3 funds opening new positions, 23 increasing their positions, 32 reducing their positions, and 11 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
84
Holders Change
-8
Holders Change %
-8.7%
% of All Funds
1.48%
Holding in Top 10
3
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.05%
New
3
Increased
23
Reduced
32
Closed
11
Calls
$340K
Puts
$119K
Net Calls
+$221K
Net Calls Change
+$770K

Top Buyers

1
Goldman Sachs
Goldman Sachs
New York
+$5.56M
2
SCM
Suvretta Capital Management
New York
+$4.82M
3
GPP
Great Point Partners
Connecticut
+$3.98M
4
Vanguard Group
Vanguard Group
Pennsylvania
+$1.76M
5
SCM
Sio Capital Management
New York
+$1.68M

Top Sellers

1
Point72 Asset Management
Point72 Asset Management
Connecticut
-$11.3M
2
NCM
Nantahala Capital Management
Connecticut
-$2.08M
3
DCM
Driehaus Capital Management
Illinois
-$1.91M
4
Millennium Management
Millennium Management
New York
-$697K
5
Russell Investments Group
Russell Investments Group
United Kingdom
-$447K
Name Holding Trade Value Shares
Change 		Shares
Change %
O
1
OrbiMed
New York
$31.8M – – –
BBA
2
Baker Bros. Advisors
New York
$27M – – –
BlackRock
3
BlackRock
New York
$26.5M +$874K +4,413 +3%
Adage Capital Partners
4
Adage Capital Partners
Massachusetts
$23.3M -$347K -1,754 -1%
BCLSI
5
Bain Capital Life Sciences Investors
Massachusetts
$21.4M – – –
PAMU
6
Pictet Asset Management (UK)
United Kingdom
$20M – – –
Vanguard Group
7
Vanguard Group
Pennsylvania
$17.2M +$1.76M +8,913 +11%
NCM
8
Nantahala Capital Management
Connecticut
$13.6M -$2.08M -10,488 -13%
ACM
9
Aisling Capital Management
New York
$13.4M – – –
RSCM
10
Rock Springs Capital Management
Maryland
$12.5M -$21.4K -108 -0.2%
Point72 Asset Management
11
Point72 Asset Management
Connecticut
$11.9M -$11.3M -56,822 -49%
SCM
12
Suvretta Capital Management
New York
$10.8M +$4.82M +24,333 +80%
Marshall Wace
13
Marshall Wace
United Kingdom
$9.44M -$412K -2,080 -4%
Goldman Sachs
14
Goldman Sachs
New York
$9M +$5.56M +28,078 +161%
AG
15
Artal Group
Luxembourg
$8.28M – – –
SB
16
Samsara BioCapital
California
$7M – – –
State Street
17
State Street
Massachusetts
$5.69M -$70.1K -354 -1%
Geode Capital Management
18
Geode Capital Management
Massachusetts
$5.21M +$719K +3,634 +16%
Dimensional Fund Advisors
19
Dimensional Fund Advisors
Texas
$4.69M +$422K +2,135 +10%
BC
20
Boxer Capital
California
$4.36M – – –
GPP
21
Great Point Partners
Connecticut
$3.98M +$3.98M +20,116 New
Northern Trust
22
Northern Trust
Illinois
$3.57M -$232K -1,170 -6%
Axa
23
Axa
France
$3.36M +$78.6K +397 +2%
SCM
24
Sio Capital Management
New York
$3.19M +$1.68M +8,462 +111%
Millennium Management
25
Millennium Management
New York
$2.94M -$697K -3,521 -19%
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