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Spyre Therapeutics
SYRE

Overview Fund Activity

68 hedge funds and large institutions have $158M invested in Spyre Therapeutics in 2019 Q4 according to their latest regulatory filings, with 9 funds opening new positions, 20 increasing their positions, 16 reducing their positions, and 12 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
68
Holders Change
-3
Holders Change %
-4.23%
% of All Funds
1.34%
Holding in Top 10
4
Holding in Top 10 Change
+2
Holding in Top 10 Change %
+100%
% of All Funds
0.08%
New
9
Increased
20
Reduced
16
Closed
12
Calls
–
Puts
–
Net Calls
–
Net Calls Change
–

Top Buyers

1
PAWC
P.A.W. Capital
Connecticut
+$764K
2
Deutsche Bank
Deutsche Bank
Germany
+$432K
3
SCA
Snowden Capital Advisors
New York
+$392K
4
Vanguard Group
Vanguard Group
Pennsylvania
+$389K
5
Two Sigma Investments
Two Sigma Investments
New York
+$379K

Top Sellers

1
DM
Deerfield Management
New York
-$3.85M
2
Nuveen Asset Management
Nuveen Asset Management
Illinois
-$375K
3
DAM
Deltec Asset Management
New York
-$192K
4
AG
Algert Global
California
-$180K
5
Squarepoint
Squarepoint
New York
-$173K
Name Holding Trade Value Shares
Change 		Shares
Change %
O
1
OrbiMed
New York
$21.9M – – –
NCM
2
Nantahala Capital Management
Connecticut
$21.8M – – –
BlackRock
3
BlackRock
New York
$14.7M +$151K +788 +1%
BBA
4
Baker Bros. Advisors
New York
$13.1M – – –
Adage Capital Partners
5
Adage Capital Partners
Massachusetts
$11.2M – – –
ACM
6
Aisling Capital Management
New York
$9.86M – – –
Vanguard Group
7
Vanguard Group
Pennsylvania
$9.02M +$389K +2,037 +5%
Marshall Wace
8
Marshall Wace
United Kingdom
$6.37M +$251K +1,312 +4%
RSCM
9
Rock Springs Capital Management
Maryland
$6.11M – – –
Renaissance Technologies
10
Renaissance Technologies
New York
$4.4M +$116K +608 +3%
Dimensional Fund Advisors
11
Dimensional Fund Advisors
Texas
$4.05M -$40.5K -212 -1%
State Street
12
State Street
Massachusetts
$3.55M +$253K +1,324 +8%
SCM
13
Soleus Capital Management
Connecticut
$3.5M +$3.5M +18,327 New
Goldman Sachs
14
Goldman Sachs
New York
$3.38M +$53.9K +282 +2%
UOTTAIMCU
15
University of Texas/Texas AM Investment Management Co (UTIMCO)
Texas
$2.47M +$2.47M +12,906 New
Geode Capital Management
16
Geode Capital Management
Massachusetts
$2.39M +$5.35K +28 +0.2%
AG
17
Artal Group
Luxembourg
$2.29M – – –
Northern Trust
18
Northern Trust
Illinois
$2.24M -$64.9K -340 -3%
RWM
19
Ritholtz Wealth Management
New York
$1.87M -$153K -800 -8%
A
20
Abingworth
United Kingdom
$1.84M – – –
Russell Investments Group
21
Russell Investments Group
United Kingdom
$1.16M – – –
BCM
22
Bridgeway Capital Management
Texas
$783K – – –
PAWC
23
P.A.W. Capital
Connecticut
$764K +$764K +4,000 New
Bank of New York Mellon
24
Bank of New York Mellon
New York
$691K +$5.74K +30 +0.8%
Nuveen Asset Management
25
Nuveen Asset Management
Illinois
$680K -$375K -1,963 -36%
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