Two Sigma Investments
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Two Sigma Investments’s Spyre Therapeutics SYRE Stock Holding History

Two Sigma Investments’s Portfolio SYRE Stock Details SYRE Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2025
Q1 		– Sell
-9,638
Closed -$224K – 3477
2024
Q4 		$224K Sell
9,638
-165
-2% -$4.84K ﹤0.01% 2841
2024
Q3 		$288K Sell
9,803
-39
-0.4% -$1.09K ﹤0.01% 2684
2024
Q2 		$231K Sell
9,842
-3,513
-26% -$118K ﹤0.01% 2690
2024
Q1 		$507K Sell
13,355
-14,740
-52% -$427K ﹤0.01% 2329
2023
Q4 		$605K Buy
+28,095
New +$387K ﹤0.01% 2359
2023
Q2 		– Sell
-12,820
Closed -$92.9K – 3253
2023
Q1 		$92.9K Sell
12,820
-2,926
-19% -$32.1K ﹤0.01% 2681
2022
Q4 		$177K Buy
15,746
+11,602
+280% +$209K ﹤0.01% 2419
2022
Q3 		$54K Sell
4,144
-8,490
-67% -$105K ﹤0.01% 2309
2022
Q2 		$160K Buy
12,634
+3,970
+46% +$139K ﹤0.01% 2205
2022
Q1 		$498K Buy
8,664
+6,084
+236% +$511K ﹤0.01% 2013
2021
Q4 		$306K Buy
+2,580
New +$407K ﹤0.01% 3640
2021
Q2 		– Sell
-733
Closed -$145K – 4543
2021
Q1 		$145K Sell
733
-1,838
-71% -$353K ﹤0.01% 3676
2020
Q4 		$506K Sell
2,571
-3,060
-54% -$634K ﹤0.01% 2510
2020
Q3 		$998K Buy
5,631
+2,334
+71% +$432K ﹤0.01% 1759
2020
Q2 		$762K Buy
3,297
+1,880
+133% +$358K ﹤0.01% 1712
2020
Q1 		$165K Sell
1,417
-568
-29% -$96.6K ﹤0.01% 2717
2019
Q4 		$379K Buy
+1,985
New +$390K ﹤0.01% 3011
2019
Q3 		– Sell
-1,978
Closed -$339K – 3779
2019
Q2 		$339K Buy
+1,978
New +$342K ﹤0.01% 2786
2018
Q4 		– Sell
-1,055
Closed -$252K – 3504
2018
Q3 		$252K Buy
1,055
+574
+119% +$134K ﹤0.01% 2876
2018
Q2 		$127K Buy
+481
New +$118K ﹤0.01% 3188

Other funds holding SYRE

Fidelity Investments
Fidelity Investments Boston, Massachusetts $1.9T AUM 41.92% 1-Year Est. Return
FFM
Fairmount Funds Management West Conshohocken, Pennsylvania $1.38B AUM 407.79% 1-Year Est. Return
RI
RTW Investments New York $10B AUM 135.35% 1-Year Est. Return
BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
Vanguard Group
Vanguard Group Malvern, Pennsylvania $6.9T AUM 27.45% 1-Year Est. Return
DCM
Driehaus Capital Management Chicago, Illinois $13.6B AUM 173.98% 1-Year Est. Return
VA
VR Adviser New York $2.68B AUM 422.73% 1-Year Est. Return
B
Braidwell Stamford, Connecticut $3B AUM 46.72% 1-Year Est. Return
Capital International Investors
Capital International Investors Los Angeles, California $427B AUM 29.17% 1-Year Est. Return
PA
Perceptive Advisors New York $5.12B AUM 314.02% 1-Year Est. Return

Two Sigma Investments's SYRE Position: Q1 2025 in Review

Two Sigma Investments sold out of Spyre Therapeutics (SYRE) in Q1 2025, closing a stake of 9,638 shares — an estimated $224K sold.

Two Sigma Investments first reported a position in SYRE in Q2 2018 and held it in 20 quarters. The position peaked at $998K in Q3 2020. 129 funds tracked by Wall St. Rank hold SYRE as of Q1 2025.

  • Two Sigma Investments reported no remaining Spyre Therapeutics position as of Q1 2025 after selling out during the quarter.
  • Two Sigma Investments sold 9,638 Spyre Therapeutics shares in Q1 2025, an estimated $224K.
  • Two Sigma Investments first reported a position in Spyre Therapeutics in Q2 2018 and held it in 20 quarters.
  • Two Sigma Investments's Spyre Therapeutics position peaked at $998K in Q3 2020.
  • 129 funds tracked by Wall St. Rank held Spyre Therapeutics as of Q1 2025.

Based on Two Sigma Investments's 13F filing for Q1 2025, filed 15 May 2025.