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Spyre Therapeutics
SYRE

Overview Fund Activity

64 hedge funds and large institutions have $155M invested in Spyre Therapeutics in 2018 Q2 according to their latest regulatory filings, with 32 funds opening new positions, 22 increasing their positions, 4 reducing their positions, and 6 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
64
Holders Change
+26
Holders Change %
+68.42%
% of All Funds
1.47%
Holding in Top 10
1
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.02%
New
32
Increased
22
Reduced
4
Closed
6
Calls
–
Puts
–
Net Calls
–
Net Calls Change
–

Top Buyers

1
BlackRock
BlackRock
New York
+$8.44M
2
Adage Capital Partners
Adage Capital Partners
Massachusetts
+$6.78M
3
SFM
Sphera Funds Management
Israel
+$5.39M
4
Renaissance Technologies
Renaissance Technologies
New York
+$4.51M
5
Millennium Management
Millennium Management
New York
+$4.26M

Top Sellers

1
UOTTAIMCU
University of Texas/Texas AM Investment Management Co (UTIMCO)
Texas
-$1.95M
2
DZ Bank
DZ Bank
Germany
-$649K
3
SIM
Spark Investment Management
New York
-$188K
4
ARTA
A.R.T. Advisors
New York
-$183K
5
PAM
Panagora Asset Management
Massachusetts
-$158K
Name Holding Trade Value Shares
Change 		Shares
Change %
NCM
1
Nantahala Capital Management
Connecticut
$23.4M +$3.9M +14,735 +20%
O
2
OrbiMed
New York
$19.7M +$4.19M +15,840 +27%
Jennison Associates
3
Jennison Associates
New York
$16.1M +$215K +814 +1%
BBA
4
Baker Bros. Advisors
New York
$14.7M +$2.65M +10,000 +22%
Adage Capital Partners
5
Adage Capital Partners
Massachusetts
$9.42M +$6.78M +25,628 +256%
BlackRock
6
BlackRock
New York
$8.7M +$8.44M +31,920 +3,257%
Vanguard Group
7
Vanguard Group
Pennsylvania
$7.38M +$3.81M +14,417 +107%
RSCM
8
Rock Springs Capital Management
Maryland
$6.88M +$1.33M +5,036 +24%
Renaissance Technologies
9
Renaissance Technologies
New York
$5.59M +$4.51M +17,048 +418%
SFM
10
Sphera Funds Management
Israel
$5.39M +$5.39M +20,365 New
Millennium Management
11
Millennium Management
New York
$5.04M +$4.26M +16,091 +542%
UOTTAIMCU
12
University of Texas/Texas AM Investment Management Co (UTIMCO)
Texas
$3.6M -$1.95M -7,370 -35%
Man Group
13
Man Group
United Kingdom
$3.45M +$3.45M +13,024 New
State Street
14
State Street
Massachusetts
$2.37M +$2.37M +8,941 New
SFM
15
Soros Fund Management
New York
$2.18M +$2.18M +8,256 New
Deutsche Bank
16
Deutsche Bank
Germany
$1.96M +$1.96M +7,420 New
Northern Trust
17
Northern Trust
Illinois
$1.87M +$1.68M +6,356 +869%
SI
18
SCP Investment
California
$1.65M +$1.65M +6,245 New
DAM
19
Deltec Asset Management
New York
$1.61M +$1.61M +6,071 New
Geode Capital Management
20
Geode Capital Management
Massachusetts
$1.56M +$1.23M +4,670 +381%
JPMorgan Chase & Co
21
JPMorgan Chase & Co
New York
$1.27M +$734K +2,775 +137%
BCM
22
Bridgeway Capital Management
Texas
$1.06M – – –
Dimensional Fund Advisors
23
Dimensional Fund Advisors
Texas
$972K – – –
OAM
24
Oxford Asset Management
United Kingdom
$899K +$899K +3,373 New
UBS Group
25
UBS Group
Switzerland
$784K +$524K +1,978 +201%
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