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Spyre Therapeutics
SYRE

Overview Fund Activity

103 hedge funds and large institutions have $1.21B invested in Spyre Therapeutics in 2024 Q1 according to their latest regulatory filings, with 55 funds opening new positions, 20 increasing their positions, 15 reducing their positions, and 6 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
103
Holders Change
+49
Holders Change %
+90.74%
% of All Funds
1.49%
Holding in Top 10
5
Holding in Top 10 Change
+2
Holding in Top 10 Change %
+66.67%
% of All Funds
0.07%
New
55
Increased
20
Reduced
15
Closed
6
Calls
$76K
Puts
–
Net Calls
+$76K
Net Calls Change
+$32K

Top Buyers

1
Fidelity Investments
Fidelity Investments
Massachusetts
+$105M
2
BlackRock
BlackRock
New York
+$20.4M
3
DGM
Darwin Global Management
Jersey
+$17.9M
4
FCM
Farallon Capital Management
California
+$17.7M
5
FTM
First Turn Management
California
+$17.6M

Top Sellers

1
DTC
Deep Track Capital
Connecticut
-$28M
2
CAM
Cormorant Asset Management
Massachusetts
-$26.1M
3
EC
EcoR1 Capital
California
-$19.1M
4
GEM
Global Endowment Management
North Carolina
-$18.8M
5
HS
HighVista Strategies
Massachusetts
-$16.1M
Name Holding Trade Value Shares
Change 		Shares
Change %
Fidelity Investments
1
Fidelity Investments
Massachusetts
$247M +$105M +2,797,878 +74%
PA
2
Perceptive Advisors
New York
$97M -$1.9M -50,000 -2%
RI
3
RTW Investments
New York
$84.7M – – –
VA
4
VR Adviser
New York
$82.4M -$7.62M -200,932 -8%
CC
5
Commodore Capital
New York
$71.5M – – –
ACA
6
Avoro Capital Advisors
New York
$69.8M – – –
DTC
7
Deep Track Capital
Connecticut
$46M -$28M -739,340 -38%
Adage Capital Partners
8
Adage Capital Partners
Massachusetts
$41.9M +$3.99M +105,200 +11%
Wellington Management Group
9
Wellington Management Group
Massachusetts
$30.8M +$6.73M +177,405 +28%
Franklin Resources
10
Franklin Resources
California
$28.1M +$2.08M +54,814 +8%
Citadel Advisors
11
Citadel Advisors
Florida
$26.8M +$4.96M +130,879 +23%
DCM
12
Driehaus Capital Management
Illinois
$26.1M -$3.22M -84,822 -11%
BlackRock
13
BlackRock
New York
$21.1M +$20.4M +536,929 +2,717%
B
14
Braidwell
Connecticut
$19.5M – – –
PCH
15
Polar Capital Holdings
United Kingdom
$19M – – –
Vanguard Group
16
Vanguard Group
Pennsylvania
$18.9M +$17.4M +457,735 +1,160%
DGM
17
Darwin Global Management
Jersey
$17.9M +$17.9M +473,200 New
FCM
18
Farallon Capital Management
California
$17.7M +$17.7M +466,000 New
FTM
19
First Turn Management
California
$17.6M +$17.6M +464,435 New
YF
20
Yu Fan
$16.4M +$16.4M +737,000 New
AAA
21
Affinity Asset Advisors
New York
$15.6M -$4.08M -107,554 -21%
FFM
22
Fairmount Funds Management
Pennsylvania
$14.4M – – –
Geode Capital Management
23
Geode Capital Management
Massachusetts
$12.5M +$11.4M +299,899 +989%
Millennium Management
24
Millennium Management
New York
$12.1M +$8.01M +211,077 +195%
CAM
25
Cormorant Asset Management
Massachusetts
$9.48M -$26.1M -687,080 -73%
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