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Spyre Therapeutics

94 hedge funds and large institutions have $275M invested in Spyre Therapeutics in 2020 Q3 according to their latest regulatory filings, with 17 funds opening new positions, 23 increasing their positions, 31 reducing their positions, and 10 closing their positions.

New
Increased
Maintained
Reduced
Closed

70% more first-time investments, than exits

New positions opened: 17 | Existing positions closed: 10

8% more funds holding

Funds holding: 8794 (+7)

0.07% more ownership

Funds ownership: 3.41%3.48% (+0.07%)

22% less capital invested

Capital invested by funds: $352M → $275M (-$76.7M)

26% less repeat investments, than reductions

Existing positions increased: 23 | Existing positions reduced: 31

33% less funds holding in top 10

Funds holding in top 10: 32 (-1)

Holders
94
Holders Change
+7
Holders Change %
+8.05%
% of All Funds
1.9%
Holding in Top 10
2
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-33.33%
% of All Funds
0.04%
New
17
Increased
23
Reduced
31
Closed
10
Calls
$1K
Puts
Net Calls
+$1K
Net Calls Change
+$1K
Name Holding Trade Value Shares
Change
Change in
Stake
BBA
1
Baker Bros. Advisors
New York
$31.1M
O
2
OrbiMed
New York
$28.5M
BlackRock
3
BlackRock
New York
$22.2M -$659K -3,562 -3%
NCM
4
Nantahala Capital Management
Connecticut
$22.1M -$602K -3,256 -3%
Adage Capital Partners
5
Adage Capital Partners
Massachusetts
$21.2M +$740K +4,000 +3%
BCLSI
6
Bain Capital Life Sciences Investors
Massachusetts
$19.1M
Vanguard Group
7
Vanguard Group
Pennsylvania
$13.1M +$29.2K +158 +0.2%
ACM
8
Aisling Capital Management
New York
$12M
RSCM
9
Rock Springs Capital Management
Maryland
$11.3M
Marshall Wace
10
Marshall Wace
United Kingdom
$8.81M -$48.1K -260 -0.5%
PAMU
11
Pictet Asset Management (UK)
United Kingdom
$8.05M +$8.41M +45,438 New
AG
12
Artal Group
Luxembourg
$7.41M -$407K -2,200 -5%
SB
13
Samsara BioCapital
California
$6.27M -$620K -3,351 -9%
State Street
14
State Street
Massachusetts
$4.66M +$30K +162 +0.6%
Geode Capital Management
15
Geode Capital Management
Massachusetts
$4.03M -$105K -568 -2%
BC
16
Boxer Capital
California
$3.9M
SCM
17
Suvretta Capital Management
New York
$3.75M +$3.04M +16,447 +349%
Dimensional Fund Advisors
18
Dimensional Fund Advisors
Texas
$3.54M +$5.37K +29 +0.1%
Northern Trust
19
Northern Trust
Illinois
$3.35M -$202K -1,091 -5%
Goldman Sachs
20
Goldman Sachs
New York
$3.17M -$51.8K -280 -2%
DCM
21
Driehaus Capital Management
Illinois
$2.99M -$55.7K -301 -2%
OM
22
Opaleye Management
Massachusetts
$2.66M +$2.77M +15,000 New
Renaissance Technologies
23
Renaissance Technologies
New York
$2.46M -$1.53M -8,272 -37%
Axa
24
Axa
France
$2.16M +$2.26M +12,205 New
LPC
25
Lion Point Capital
New York
$2.13M

SYRE Hedge Fund Activity: Q3 2020 in Review

94 of the 4,957 institutional investors tracked by Wall St. Rank reported a position in Spyre Therapeutics (SYRE) for Q3 2020, worth a combined $275M — down 22% from $352M a quarter earlier.

Buyers outnumbered sellers: 17 funds opened new SYRE positions and 10 closed out — a net gain of 7 holders — while 23 added to existing stakes and 31 trimmed.

The largest buyer was Pictet Asset Management (UK), opening a new position worth an estimated $8.41M. The largest seller was Deerfield Management, exiting entirely with an estimated $7.63M sold.

  • 94 institutional investors held Spyre Therapeutics (SYRE) as of Q3 2020, up from 87 in Q2 2020.
  • Funds reported $275M of Spyre Therapeutics stock for Q3 2020, down 22% quarter-over-quarter.
  • 17 funds opened new Spyre Therapeutics positions in Q3 2020 and 10 closed out, a net change of +7 holders.
  • The largest Spyre Therapeutics buyer in Q3 2020 was Pictet Asset Management (UK), an estimated $8.41M added.
  • The largest Spyre Therapeutics seller in Q3 2020 was Deerfield Management, an estimated $7.63M sold.

Based on aggregated 13F filings for Q3 2020.