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Spyre Therapeutics
SYRE

Overview Fund Activity

78 hedge funds and large institutions have $286M invested in Spyre Therapeutics in 2021 Q2 according to their latest regulatory filings, with 3 funds opening new positions, 29 increasing their positions, 26 reducing their positions, and 9 closing their positions.

Holders
78
Holders Change
-6
Holders Change %
-7.14%
% of All Funds
1.36%
Holding in Top 10
3
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.05%
New
3
Increased
29
Reduced
26
Closed
9
Calls
$316K
Puts
$104K
Net Calls
+$212K
Net Calls Change
-$9K

Top Buyers

1
SCM
1
Suvretta Capital Management
New York
$14.6M
2
GPP
2
Great Point Partners
Connecticut
$6.26M
3
ACM
3
Altium Capital Management
New York
$4.24M
4
Millennium Management
4
Millennium Management
New York
$3.78M
5
Assenagon Asset Management
5
Assenagon Asset Management
Luxembourg
$1.96M

Top Sellers

1
Point72 Asset Management
1
Point72 Asset Management
Connecticut
$3.27M
2
Marshall Wace
2
Marshall Wace
United Kingdom
$4.53M
3
BlackRock
3
BlackRock
New York
$21.6M
4
DCM
4
Driehaus Capital Management
Illinois
$0
5
Jacobs Levy Equity Management
5
Jacobs Levy Equity Management
New Jersey
$413K
Name Market Value Shares Shares
Change 		Shares
Change %
O
1
OrbiMed
New York
$27.9M 4,015,524 – –
BBA
2
Baker Bros. Advisors
New York
$23.7M 3,410,106 – –
BlackRock
3
BlackRock
New York
$21.6M 3,103,879 -246,433 -7%
Adage Capital Partners
4
Adage Capital Partners
Massachusetts
$21.2M 3,049,581 +101,440 +3%
BCLSI
5
Bain Capital Life Sciences Investors
Massachusetts
$18.8M 2,700,000 – –
PAMU
6
Pictet Asset Management (UK)
United Kingdom
$17.6M 2,532,799 +13,465 +0.5%
Vanguard Group
7
Vanguard Group
Pennsylvania
$14.6M 2,097,166 -76,896 -4%
SCM
8
Suvretta Capital Management
New York
$14.6M 2,094,100 +727,027 +53%
ACM
9
Aisling Capital Management
New York
$11.8M 1,691,151 – –
NCM
10
Nantahala Capital Management
Connecticut
$11.7M 1,677,036 -35,052 -2%
RSCM
11
Rock Springs Capital Management
Maryland
$11M 1,577,296 – –
Goldman Sachs
12
Goldman Sachs
New York
$7.87M 1,131,059 -5,614 -0.5%
AG
13
Artal Group
Luxembourg
$7.27M 1,045,000 – –
GPP
14
Great Point Partners
Connecticut
$6.26M 900,000 +397,100 +79%
SB
15
Samsara BioCapital
California
$6.15M 883,720 – –
State Street
16
State Street
Massachusetts
$5.27M 757,500 +39,025 +5%
Geode Capital Management
17
Geode Capital Management
Massachusetts
$4.72M 677,726 +19,856 +3%
Marshall Wace
18
Marshall Wace
United Kingdom
$4.53M 651,403 -539,836 -45%
ACM
19
Altium Capital Management
New York
$4.24M 609,689 +341,936 +128%
Dimensional Fund Advisors
20
Dimensional Fund Advisors
Texas
$4.21M 604,112 +10,695 +2%
BC
21
Boxer Capital
California
$3.83M 550,000 – –
Millennium Management
22
Millennium Management
New York
$3.78M 543,185 +172,049 +46%
Point72 Asset Management
23
Point72 Asset Management
Connecticut
$3.27M 469,765 -1,030,235 -69%
Axa
24
Axa
France
$2.95M 424,352 +432 +0.1%
SCM
25
Sio Capital Management
New York
$2.8M 402,653 – –
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