Driehaus Capital Management’s Spyre Therapeutics SYRE Stock Holding History

Driehaus Capital Management’s Portfolio SYRE Stock Details SYRE Fund Activity

Bought

Maintained

Sold

Quarter	Market Value	Status	Shares	Change in Stake	Trade Value	Portfolio Weight	Portfolio Position
2026 Q1	$141M	Sell	2,790,785 -91,635	-3%	-$3.45M	1.03%	14
2025 Q4	$94.4M	Buy	2,882,420 +822,045	+40%	+$21.5M	0.64%	38
2025 Q3	$34.5M	Sell	2,060,375 -25,215	-1%	-$411K	0.25%	134
2025 Q2	$31.2M	Sell	2,085,590 -631,722	-23%	-$9.35M	0.25%	131
2025 Q1	$43.8M	Sell	2,717,312 -86,343	-3%	-$1.8M	0.42%	71
2024 Q4	$65.3M	Buy	2,803,655 +2,116,575	+308%	+$62.1M	0.54%	52
2024 Q3	$20.2M	Hold	687,080	–	–	0.17%	168
2024 Q2	$16.2M	Hold	687,080	–	–	0.16%	175
2024 Q1	$26.1M	Sell	687,080 -84,822	-11%	-$2.46M	0.26%	113
2023 Q4	$16.6M	Sell	771,902 -28,951	-4%	-$399K	0.2%	169
2023 Q3	$9.81M	Buy	800,853 +615,119	+331%	+$8.13M	0.13%	211
2023 Q2	$2.09M	Buy	+185,734	New	+$881K	0.03%	299
2021 Q2	–	Sell	-7,000	Closed	-$1.39M	–	514
2021 Q1	$1.39M	Sell	7,000 -9,651	-58%	-$1.85M	0.02%	339
2020 Q4	$3.28M	Sell	16,651 -236	-1%	-$48.9K	0.05%	272
2020 Q3	$2.99M	Sell	16,887 -301	-2%	-$55.7K	0.06%	239
2020 Q2	$3.98M	Buy	+17,188	New	+$3.27M	0.1%	214

Other funds holding SYRE

Fidelity Investments

Fidelity Investments Boston, Massachusetts $1.9T AUM 41.92% 1-Year Est. Return

BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return

RTW Investments New York $10B AUM 135.35% 1-Year Est. Return

Fairmount Funds Management West Conshohocken, Pennsylvania $1.38B AUM 407.79% 1-Year Est. Return

Perceptive Advisors New York $5.12B AUM 314.02% 1-Year Est. Return

VR Adviser New York $2.68B AUM 422.73% 1-Year Est. Return

Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM

State Street Boston, Massachusetts $2.9T AUM 29.55% 1-Year Est. Return

Paradigm Biocapital Advisors New York $4.89B AUM 251.12% 1-Year Est. Return

Commodore Capital New York $1.73B AUM 298.96% 1-Year Est. Return