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Spyre Therapeutics
SYRE

Overview Fund Activity

129 hedge funds and large institutions have $1B invested in Spyre Therapeutics in 2025 Q1 according to their latest regulatory filings, with 20 funds opening new positions, 52 increasing their positions, 35 reducing their positions, and 21 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
129
Holders Change
-2
Holders Change %
-1.53%
% of All Funds
1.75%
Holding in Top 10
2
Holding in Top 10 Change
-2
Holding in Top 10 Change %
-50%
% of All Funds
0.03%
New
20
Increased
52
Reduced
35
Closed
21
Calls
$827K
Puts
$1.01M
Net Calls
-$182K
Net Calls Change
-$264K

Top Buyers

1
Capital International Investors
Capital International Investors
California
+$38.6M
2
TCM
Tang Capital Management
California
+$33.1M
3
PBA
Paradigm Biocapital Advisors
New York
+$9.68M
4
Bank of America
Bank of America
North Carolina
+$6.78M
5
Fidelity Investments
Fidelity Investments
Massachusetts
+$3.83M

Top Sellers

1
Citadel Advisors
Citadel Advisors
Florida
-$15.3M
2
LGM
Logos Global Management
California
-$11.6M
3
BCM
Boxer Capital Management
California
-$10.9M
4
Goldman Sachs
Goldman Sachs
New York
-$8.88M
5
Janus Henderson Group
Janus Henderson Group
United Kingdom
-$7.45M
Name Holding Trade Value Shares
Change 		Shares
Change %
Fidelity Investments
1
Fidelity Investments
Massachusetts
$146M +$3.83M +237,287 +3%
FFM
2
Fairmount Funds Management
Pennsylvania
$64.8M – – –
RI
3
RTW Investments
New York
$58.4M – – –
BlackRock
4
BlackRock
New York
$57.6M +$2.79M +173,083 +5%
Vanguard Group
5
Vanguard Group
Pennsylvania
$46.8M +$836K +51,794 +2%
DCM
6
Driehaus Capital Management
Illinois
$43.8M -$1.39M -86,343 -3%
VA
7
VR Adviser
New York
$43.3M – – –
B
8
Braidwell
Connecticut
$41.6M – – –
Capital International Investors
9
Capital International Investors
California
$38.6M +$38.6M +2,392,541 New
PA
10
Perceptive Advisors
New York
$37.3M -$4.22M -261,451 -10%
PBA
11
Paradigm Biocapital Advisors
New York
$34.3M +$9.68M +600,000 +39%
TCM
12
Tang Capital Management
California
$33.1M +$33.1M +2,050,000 New
CC
13
Commodore Capital
New York
$32.1M – – –
State Street
14
State Street
Massachusetts
$27.4M +$261K +16,179 +1%
Wellington Management Group
15
Wellington Management Group
Massachusetts
$25.7M -$175K -10,830 -0.7%
JFG
16
Jefferies Financial Group
New York
$20.2M +$515K +31,900 +3%
Janus Henderson Group
17
Janus Henderson Group
United Kingdom
$18.7M -$7.45M -415,330 -29%
Pictet Asset Management
18
Pictet Asset Management
Switzerland
$17.2M -$375K -23,232 -2%
Geode Capital Management
19
Geode Capital Management
Massachusetts
$17.1M +$1.51M +93,434 +10%
PCH
20
Polar Capital Holdings
United Kingdom
$13.3M +$1.21M +75,000 +10%
Adage Capital Partners
21
Adage Capital Partners
Massachusetts
$13M -$3.66M -226,800 -22%
Franklin Resources
22
Franklin Resources
California
$12.3M -$226 -14 -0%
UBS Group
23
UBS Group
Switzerland
$8.91M +$2.58M +160,046 +41%
EA
24
Emerald Advisers
Pennsylvania
$8.84M +$16.7K +1,036 +0.2%
Blackstone Inc
25
Blackstone Inc
New York
$7.89M +$646K +40,047 +9%
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