BCM
SYRE icon

Boxer Capital Management’s Spyre Therapeutics SYRE Stock Holding History

Boxer Capital Management’s Portfolio SYRE Stock Details SYRE Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q2 		$8.88M Buy
+100,000
New +$7.3M 0.67% 27
2025
Q1 		– Sell
-466,680
Closed -$10.9M – 55
2024
Q4 		$10.9M Buy
+466,680
New +$13.7M 0.93% 30

Other funds holding SYRE

Fidelity Investments
Fidelity Investments Boston, Massachusetts $2.3T AUM 54.33% 1-Year Est. Return
BlackRock
BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return
PA
Perceptive Advisors New York $6.66B AUM 360.84% 1-Year Est. Return
RI
RTW Investments New York $11.7B AUM 174.13% 1-Year Est. Return
PBA
Paradigm Biocapital Advisors New York $5.34B AUM 380.18% 1-Year Est. Return
Vanguard Capital Management
Vanguard Capital Management Malvern, Pennsylvania $4.68T AUM
State Street
State Street Boston, Massachusetts $3.37T AUM 44.26% 1-Year Est. Return
VA
VR Adviser New York $3.3B AUM 525.74% 1-Year Est. Return
T. Rowe Price Associates
T. Rowe Price Associates Baltimore, Maryland $999B AUM 46.22% 1-Year Est. Return
DCM
Driehaus Capital Management Chicago, Illinois $17.3B AUM 211.34% 1-Year Est. Return

Boxer Capital Management's SYRE Position: Q2 2026 in Review

Boxer Capital Management opened a new position in Spyre Therapeutics (SYRE) in Q2 2026: 100,000 shares worth $8.88M. The stake represents 0.67% of the portfolio and ranks #27 among its holdings. This is a return to the name: Boxer Capital Management previously reported a position in SYRE as recently as Q4 2024.

Boxer Capital Management first reported a position in SYRE in Q4 2024 and has held it in 2 quarters since. The position peaked at $10.9M in Q4 2024. 266 funds tracked by Wall St. Rank hold SYRE as of Q2 2026.

  • Boxer Capital Management held 100,000 shares of Spyre Therapeutics worth $8.88M as of Q2 2026.
  • Spyre Therapeutics was a new Boxer Capital Management position in Q2 2026.
  • Spyre Therapeutics made up 0.67% of Boxer Capital Management's portfolio in Q2 2026, its #27 holding.
  • Boxer Capital Management first reported a position in Spyre Therapeutics in Q4 2024 and has held it in 2 quarters since.
  • Boxer Capital Management's Spyre Therapeutics position peaked at $10.9M in Q4 2024.
  • 266 funds tracked by Wall St. Rank held Spyre Therapeutics as of Q2 2026.

Based on Boxer Capital Management's 13F filing for Q2 2026, filed 14 Aug 2026.