RA Capital Management’s Spyre Therapeutics SYRE Stock Holding History

RA Capital Management’s Portfolio SYRE Stock Details SYRE Fund Activity

Bought

Maintained

Sold

Quarter	Market Value	Status	Shares	Change in Stake	Trade Value	Portfolio Weight	Portfolio Position
2026 Q2	–	Sell	-1,621,620	Closed	-$81.8M	–	94
2026 Q1	$81.8M	Hold	1,621,620	–	–	0.87%	26
2025 Q4	$53.1M	Buy	+1,621,620	New	+$42.4M	0.54%	34
2022 Q4	–	Sell	-418	Closed	-$5K	–	82
2022 Q3	$5K	Buy	+418	New	+$5.16K	﹤0.01%	81
2016 Q4	–	Sell	-13,445	Closed	-$2.15M	–	33
2016 Q3	$2.15M	Sell	13,445 -7,417	-36%	-$1.03M	0.22%	28
2016 Q2	$2.54M	Buy	+20,862	New	+$4M	0.35%	28

Other funds holding SYRE

Fidelity Investments Boston, Massachusetts $2.3T AUM 54.33% 1-Year Est. Return

BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return

Perceptive Advisors New York $6.66B AUM 360.84% 1-Year Est. Return

RTW Investments New York $11.7B AUM 174.13% 1-Year Est. Return

PBA

Paradigm Biocapital Advisors New York $5.34B AUM 380.18% 1-Year Est. Return

Vanguard Capital Management Malvern, Pennsylvania $4.68T AUM

State Street Boston, Massachusetts $3.37T AUM 44.26% 1-Year Est. Return

VR Adviser New York $3.3B AUM 525.74% 1-Year Est. Return

T. Rowe Price Associates Baltimore, Maryland $999B AUM 46.22% 1-Year Est. Return

DCM

Driehaus Capital Management Chicago, Illinois $17.3B AUM 211.34% 1-Year Est. Return

RA Capital Management's SYRE Position: Q2 2026 in Review

RA Capital Management sold out of Spyre Therapeutics (SYRE) in Q2 2026, closing a stake of 1,621,620 shares — an estimated $81.8M sold.

RA Capital Management first reported a position in SYRE in Q2 2016 and held it in 5 quarters. The position peaked at $81.8M in Q1 2026. 266 funds tracked by Wall St. Rank hold SYRE as of Q2 2026.

RA Capital Management reported no remaining Spyre Therapeutics position as of Q2 2026 after selling out during the quarter.
RA Capital Management sold 1,621,620 Spyre Therapeutics shares in Q2 2026, an estimated $81.8M.
RA Capital Management first reported a position in Spyre Therapeutics in Q2 2016 and held it in 5 quarters.
RA Capital Management's Spyre Therapeutics position peaked at $81.8M in Q1 2026.
266 funds tracked by Wall St. Rank held Spyre Therapeutics as of Q2 2026.

Based on RA Capital Management's 13F filing for Q2 2026, filed 14 Aug 2026.