State of Wisconsin Investment Board
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State of Wisconsin Investment Board’s Spyre Therapeutics SYRE Stock Holding History

State of Wisconsin Investment Board’s Portfolio SYRE Stock Details SYRE Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q2 		$4M Buy
45,030
+18,507
+70% +$1.35M 0.01% 1176
2026
Q1 		$1.34M Sell
26,523
-729
-3% -$27.5K ﹤0.01% 1562
2025
Q4 		$893K Sell
27,252
-6,294
-19% -$164K ﹤0.01% 1719
2025
Q3 		$562K Sell
33,546
-1,500
-4% -$24.5K ﹤0.01% 1828
2025
Q2 		$525K Buy
35,046
+145
+0.4% +$2.15K ﹤0.01% 1837
2025
Q1 		$563K Buy
34,901
+3,417
+11% +$71.1K ﹤0.01% 1709
2024
Q4 		$733K Buy
31,484
+13,169
+72% +$386K ﹤0.01% 1643
2024
Q3 		$539K Buy
18,315
+4,383
+31% +$122K ﹤0.01% 1833
2024
Q2 		$328K Sell
13,932
-700
-5% -$23.6K ﹤0.01% 2001
2024
Q1 		$555K Buy
+14,632
New +$424K ﹤0.01% 1689
2021
Q2 		– Sell
-2,412
Closed -$478K – 2156
2021
Q1 		$478K Hold
2,412
– – ﹤0.01% 1615
2020
Q4 		$475K Sell
2,412
-300
-11% -$62.2K ﹤0.01% 1558
2020
Q3 		$481K Buy
+2,712
New +$502K ﹤0.01% 1486
2020
Q1 		– Sell
-1,588
Closed -$303K – 1733
2019
Q4 		$303K Buy
1,588
+805
+103% +$158K ﹤0.01% 1540
2019
Q3 		$151K Sell
783
-101
-11% -$19.7K ﹤0.01% 1519
2019
Q2 		$151K Buy
884
+20
+2% +$3.46K ﹤0.01% 1504
2019
Q1 		$174K Buy
864
+196
+29% +$40.9K ﹤0.01% 1473
2018
Q4 		$125K Buy
+668
New +$142K ﹤0.01% 1486

Other funds holding SYRE

Fidelity Investments
Fidelity Investments Boston, Massachusetts $2.3T AUM 54.33% 1-Year Est. Return
BlackRock
BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return
PA
Perceptive Advisors New York $6.66B AUM 360.84% 1-Year Est. Return
RI
RTW Investments New York $11.7B AUM 174.13% 1-Year Est. Return
PBA
Paradigm Biocapital Advisors New York $5.34B AUM 380.18% 1-Year Est. Return
Vanguard Capital Management
Vanguard Capital Management Malvern, Pennsylvania $4.68T AUM
State Street
State Street Boston, Massachusetts $3.37T AUM 44.26% 1-Year Est. Return
VA
VR Adviser New York $3.3B AUM 525.74% 1-Year Est. Return
T. Rowe Price Associates
T. Rowe Price Associates Baltimore, Maryland $999B AUM 46.22% 1-Year Est. Return
DCM
Driehaus Capital Management Chicago, Illinois $17.3B AUM 211.34% 1-Year Est. Return

State of Wisconsin Investment Board's SYRE Position: Q2 2026 in Review

State of Wisconsin Investment Board increased its Spyre Therapeutics (SYRE) stake by 70% in Q2 2026, buying an estimated $1.35M and bringing the position to 45,030 shares worth $4M. The position accounts for 0.01% of the portfolio, ranked #1176.

State of Wisconsin Investment Board first reported a position in SYRE in Q4 2018 and has held it in 18 quarters since. 265 funds tracked by Wall St. Rank hold SYRE as of Q2 2026.

  • State of Wisconsin Investment Board held 45,030 shares of Spyre Therapeutics worth $4M as of Q2 2026.
  • State of Wisconsin Investment Board bought 18,507 Spyre Therapeutics shares in Q2 2026, an estimated $1.35M.
  • Spyre Therapeutics made up 0.01% of State of Wisconsin Investment Board's portfolio in Q2 2026, its #1176 holding.
  • State of Wisconsin Investment Board first reported a position in Spyre Therapeutics in Q4 2018 and has held it in 18 quarters since.
  • 265 funds tracked by Wall St. Rank held Spyre Therapeutics as of Q2 2026.

Based on State of Wisconsin Investment Board's 13F filing for Q2 2026, filed 14 Aug 2026.