Vanguard Asset Management
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Vanguard Asset Management’s Spyre Therapeutics SYRE Stock Holding History

Vanguard Asset Management’s Portfolio SYRE Stock Details SYRE Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q2 		$3.48M Buy
39,220
+5,988
+18% +$437K ﹤0.01% 1258
2026
Q1 		$1.68M Buy
+33,232
New +$1.25M ﹤0.01% 1544

Other funds holding SYRE

Fidelity Investments
Fidelity Investments Boston, Massachusetts $2.3T AUM 54.33% 1-Year Est. Return
BlackRock
BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return
PA
Perceptive Advisors New York $6.66B AUM 360.84% 1-Year Est. Return
RI
RTW Investments New York $11.7B AUM 174.13% 1-Year Est. Return
PBA
Paradigm Biocapital Advisors New York $5.34B AUM 380.18% 1-Year Est. Return
Vanguard Capital Management
Vanguard Capital Management Malvern, Pennsylvania $4.68T AUM
State Street
State Street Boston, Massachusetts $3.37T AUM 44.26% 1-Year Est. Return
VA
VR Adviser New York $3.3B AUM 525.74% 1-Year Est. Return
T. Rowe Price Associates
T. Rowe Price Associates Baltimore, Maryland $999B AUM 46.22% 1-Year Est. Return
DCM
Driehaus Capital Management Chicago, Illinois $17.3B AUM 211.34% 1-Year Est. Return

Vanguard Asset Management's SYRE Position: Q2 2026 in Review

Vanguard Asset Management increased its Spyre Therapeutics (SYRE) stake by 18% in Q2 2026, buying an estimated $437K and bringing the position to 39,220 shares worth $3.48M. The position accounts for ﹤0.01% of the portfolio, ranked #1258.

Vanguard Asset Management first reported a position in SYRE in Q1 2026 and has held it in 2 quarters since. 260 funds tracked by Wall St. Rank hold SYRE as of Q2 2026.

  • Vanguard Asset Management held 39,220 shares of Spyre Therapeutics worth $3.48M as of Q2 2026.
  • Vanguard Asset Management bought 5,988 Spyre Therapeutics shares in Q2 2026, an estimated $437K.
  • Spyre Therapeutics made up ﹤0.01% of Vanguard Asset Management's portfolio in Q2 2026, its #1258 holding.
  • Vanguard Asset Management first reported a position in Spyre Therapeutics in Q1 2026 and has held it in 2 quarters since.
  • 260 funds tracked by Wall St. Rank held Spyre Therapeutics as of Q2 2026.

Based on Vanguard Asset Management's 13F filing for Q2 2026, filed 13 Aug 2026.