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Spyre Therapeutics
SYRE

Overview Fund Activity

127 hedge funds and large institutions have $950M invested in Spyre Therapeutics in 2025 Q2 according to their latest regulatory filings, with 18 funds opening new positions, 61 increasing their positions, 26 reducing their positions, and 17 closing their positions.

Holders
127
Holders Change
-2
Holders Change %
-1.55%
% of All Funds
1.71%
Holding in Top 10
3
Holding in Top 10 Change
+1
Holding in Top 10 Change %
+50%
% of All Funds
0.04%
New
18
Increased
61
Reduced
26
Closed
17
Calls
$1.05M
Puts
$603K
Net Calls
+$446K
Net Calls Change
+$628K

Top Buyers

1
TCM
1
Tang Capital Management
California
$47.9M
2
T. Rowe Price Associates
2
T. Rowe Price Associates
Maryland
$13.9M
3
BBA
3
Baker Bros. Advisors
New York
$9.38M
4
BlackRock
4
BlackRock
New York
$60M
5
Morgan Stanley
5
Morgan Stanley
New York
$10M

Top Sellers

1
Janus Henderson Group
1
Janus Henderson Group
United Kingdom
$194K
2
PA
2
Perceptive Advisors
New York
$22.9M
3
DCM
3
Driehaus Capital Management
Illinois
$31.2M
4
PBA
4
Paradigm Biocapital Advisors
New York
$28M
5
Adage Capital Partners
5
Adage Capital Partners
Massachusetts
$9.13M
Name Market Value Shares Shares
Change 		Shares
Change %
Mercer Global Advisors
51
Mercer Global Advisors
Colorado
$1.59M 106,142 +106,142 New
UBS AM
52
UBS AM
Illinois
$1.28M 85,702 +33,564 +64%
ECM
53
ExodusPoint Capital Management
New York
$1.24M 82,977 +67,922 +451%
BGI
54
B Group Inc
Texas
$1.2M 80,000 +10,000 +14%
Manulife (Manufacturers Life Insurance)
55
Manulife (Manufacturers Life Insurance)
Ontario, Canada
$1.2M 79,896 +25,995 +48%
RhumbLine Advisers
56
RhumbLine Advisers
Massachusetts
$1.1M 73,168 +17,145 +31%
FCMV
57
Foresite Capital Management VI
California
$1.05M 70,000 +70,000 New
Swiss National Bank
58
Swiss National Bank
Switzerland
$1.03M 68,600 – –
Verition Fund Management
59
Verition Fund Management
Connecticut
$974K 65,042 +65,042 New
FMI
60
F/M Investments
District of Columbia
$787K 52,546 +702 +1%
Rafferty Asset Management
61
Rafferty Asset Management
New York
$763K 50,957 -19,366 -28%
JPMorgan Chase & Co
62
JPMorgan Chase & Co
New York
$708K 47,279 +5,723 +14%
AllianceBernstein
63
AllianceBernstein
Tennessee
$542K 36,230 – –
State of Wisconsin Investment Board
64
State of Wisconsin Investment Board
Wisconsin
$525K 35,046 +145 +0.4%
Legal & General Group
65
Legal & General Group
United Kingdom
$523K 34,969 -2,875 -8%
Invesco
66
Invesco
Georgia
$519K 34,680 +9,473 +38%
Wells Fargo
67
Wells Fargo
California
$515K 34,409 +4,374 +15%
ACM
68
ADAR1 Capital Management
Texas
$510K 34,051 +19,018 +127%
Deutsche Bank
69
Deutsche Bank
Germany
$508K 33,938 +5,455 +19%
California State Teachers Retirement System (CalSTRS)
70
California State Teachers Retirement System (CalSTRS)
California
$497K 33,201 +603 +2%
Renaissance Technologies
71
Renaissance Technologies
New York
$463K 30,936 +30,936 New
Squarepoint
72
Squarepoint
New York
$450K 30,046 -41,965 -58%
MIM
73
MetLife Investment Management
New Jersey
$448K 29,918 +6,185 +26%
Mirae Asset Global ETFs Holdings
74
Mirae Asset Global ETFs Holdings
Hong Kong
$447K 29,812 +2,794 +10%
Citigroup
75
Citigroup
New York
$438K 29,261 -54,203 -65%
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