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Spyre Therapeutics
SYRE

Overview Fund Activity

127 hedge funds and large institutions have $950M invested in Spyre Therapeutics in 2025 Q2 according to their latest regulatory filings, with 18 funds opening new positions, 61 increasing their positions, 26 reducing their positions, and 17 closing their positions.

Holders
127
Holders Change
-2
Holders Change %
-1.55%
% of All Funds
1.71%
Holding in Top 10
3
Holding in Top 10 Change
+1
Holding in Top 10 Change %
+50%
% of All Funds
0.04%
New
18
Increased
61
Reduced
26
Closed
17
Calls
$1.05M
Puts
$603K
Net Calls
+$446K
Net Calls Change
+$628K

Top Buyers

1
TCM
1
Tang Capital Management
California
$47.9M
2
T. Rowe Price Associates
2
T. Rowe Price Associates
Maryland
$13.9M
3
BBA
3
Baker Bros. Advisors
New York
$9.38M
4
BlackRock
4
BlackRock
New York
$60M
5
Morgan Stanley
5
Morgan Stanley
New York
$10M

Top Sellers

1
Janus Henderson Group
1
Janus Henderson Group
United Kingdom
$194K
2
PA
2
Perceptive Advisors
New York
$22.9M
3
DCM
3
Driehaus Capital Management
Illinois
$31.2M
4
PBA
4
Paradigm Biocapital Advisors
New York
$28M
5
Adage Capital Partners
5
Adage Capital Partners
Massachusetts
$9.13M
Name Market Value Shares Shares
Change 		Shares
Change %
Carson Wealth (CWM LLC)
101
Carson Wealth (CWM LLC)
Nebraska
$26K 1,712 +1,338 +358%
Public Employees Retirement Association of Colorado
102
Public Employees Retirement Association of Colorado
Colorado
$24K 1,589 – –
GFM
103
GF Fund Management
China
$22.5K 1,502 – –
HNB
104
Huntington National Bank
Ohio
$22K 1,470 – –
AB
105
Amalgamated Bank
New York
$21K 1,379 – –
Nisa Investment Advisors
106
Nisa Investment Advisors
Missouri
$8.17K 546 +362 +197%
SCM
107
Sterling Capital Management
North Carolina
$7.84K 524 -105 -17%
BIG
108
Brooklyn Investment Group
New York
$7.79K 520 +520 New
BNP Paribas Asset Management
109
BNP Paribas Asset Management
France
$6K 377 +377 New
Daiwa Securities Group
110
Daiwa Securities Group
Japan
$3K 206 – –
Osaic Holdings
111
Osaic Holdings
Arizona
$2.86K 145 -93 -39%
GI
112
GAMMA Investing
California
$2.61K 174 -96 -36%
MAM
113
Meeder Asset Management
Ohio
$2.55K 170 +170 New
S
114
SignatureFD
Georgia
$2.47K 165 +165 New
Russell Investments Group
115
Russell Investments Group
United Kingdom
$2.13K 142 +142 New
RIL
116
Rothschild Investment LLC
Illinois
$2.1K 140 +90 +180%
Simplex Trading
117
Simplex Trading
Illinois
$2K 145 +145 New
CIAM
118
Caitong International Asset Management
Hong Kong
$1.53K 102 +74 +264%
EWA
119
EverSource Wealth Advisors
Alabama
$973 65 +41 +171%
PFBT
120
Parkside Financial Bank & Trust
Missouri
$524 35 +35 New
AF
121
Allworth Financial
California
$450 30 +17 +131%
IA
122
IFP Advisors
Florida
$374 23 -86 -79%
Raymond James Financial
123
Raymond James Financial
Florida
$240 16 +16 New
SS
124
SBI Securities
Japan
$165 11 +6 +120%
US Bancorp
125
US Bancorp
Minnesota
$150 10 +1 +11%
2 3 4
5
6