State Board of Administration of Florida Retirement System’s Spyre Therapeutics SYRE Stock Holding History

State Board of Administration of Florida Retirement System’s Portfolio SYRE Stock Details SYRE Fund Activity

Bought

Maintained

Sold

Quarter	Market Value	Status	Shares	Change in Stake	Trade Value	Portfolio Weight	Portfolio Position
2026 Q2	$1.6M	Buy	18,076 +4,171	+30%	+$304K	﹤0.01%	1149
2026 Q1	$701K	Buy	13,905 +4,875	+54%	+$184K	﹤0.01%	1397
2025 Q4	$296K	Buy	+9,030	New	+$236K	﹤0.01%	1761
2025 Q1	–	Sell	-9,030	Closed	-$210K	–	2213
2024 Q4	$210K	Hold	9,030	–	–	﹤0.01%	1936
2024 Q3	$266K	Hold	9,030	–	–	﹤0.01%	1853
2024 Q2	$212K	Buy	+9,030	New	+$305K	﹤0.01%	1929

Other funds holding SYRE

Fidelity Investments Boston, Massachusetts $2.3T AUM 54.33% 1-Year Est. Return

BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return

Perceptive Advisors New York $6.66B AUM 360.84% 1-Year Est. Return

RTW Investments New York $11.7B AUM 174.13% 1-Year Est. Return

PBA

Paradigm Biocapital Advisors New York $5.34B AUM 380.18% 1-Year Est. Return

Vanguard Capital Management Malvern, Pennsylvania $4.68T AUM

State Street Boston, Massachusetts $3.37T AUM 44.26% 1-Year Est. Return

VR Adviser New York $3.3B AUM 525.74% 1-Year Est. Return

T. Rowe Price Associates Baltimore, Maryland $999B AUM 46.22% 1-Year Est. Return

DCM

Driehaus Capital Management Chicago, Illinois $17.3B AUM 211.34% 1-Year Est. Return

State Board of Administration of Florida Retirement System's SYRE Position: Q2 2026 in Review

State Board of Administration of Florida Retirement System increased its Spyre Therapeutics (SYRE) stake by 30% in Q2 2026, buying an estimated $304K and bringing the position to 18,076 shares worth $1.6M. The position accounts for ﹤0.01% of the portfolio, ranked #1149.

State Board of Administration of Florida Retirement System first reported a position in SYRE in Q2 2024 and has held it in 6 quarters since. 265 funds tracked by Wall St. Rank hold SYRE as of Q2 2026.

State Board of Administration of Florida Retirement System held 18,076 shares of Spyre Therapeutics worth $1.6M as of Q2 2026.
State Board of Administration of Florida Retirement System bought 4,171 Spyre Therapeutics shares in Q2 2026, an estimated $304K.
Spyre Therapeutics made up ﹤0.01% of State Board of Administration of Florida Retirement System's portfolio in Q2 2026, its #1149 holding.
State Board of Administration of Florida Retirement System first reported a position in Spyre Therapeutics in Q2 2024 and has held it in 6 quarters since.
265 funds tracked by Wall St. Rank held Spyre Therapeutics as of Q2 2026.

Based on State Board of Administration of Florida Retirement System's 13F filing for Q2 2026, filed 10 Aug 2026.