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Commodore Capital’s Spyre Therapeutics SYRE Stock Holding History

Commodore Capital’s Portfolio SYRE Stock Details SYRE Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q2 		$75.2M Sell
846,786
-1,065,594
-56% -$77.8M 4.48% 7
2026
Q1 		$96.5M Sell
1,912,380
-475,865
-20% -$17.9M 5.58% 5
2025
Q4 		$78.2M Buy
2,388,245
+400,161
+20% +$10.5M 5.21% 5
2025
Q3 		$33.3M Hold
1,988,084
– – 1.63% 23
2025
Q2 		$29.8M Hold
1,988,084
– – 2.1% 19
2025
Q1 		$32.1M Hold
1,988,084
– – 2.36% 16
2024
Q4 		$46.3M Hold
1,988,084
– – 3.39% 11
2024
Q3 		$58.5M Hold
1,988,084
– – 3.65% 10
2024
Q2 		$46.7M Buy
1,988,084
+104,000
+6% +$3.51M 3.19% 13
2024
Q1 		$71.5M Hold
1,884,084
– – 4.78% 5
2023
Q4 		$40.5M Buy
1,884,084
+1,767,760
+1,520% +$24.4M 3.54% 11
2023
Q3 		$1.42M Hold
116,324
– – 0.17% 29
2023
Q2 		$1.31M Buy
+116,324
New +$552K 0.15% 25

Other funds holding SYRE

Fidelity Investments
Fidelity Investments Boston, Massachusetts $2.3T AUM 54.33% 1-Year Est. Return
BlackRock
BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return
PA
Perceptive Advisors New York $6.66B AUM 360.84% 1-Year Est. Return
RI
RTW Investments New York $11.7B AUM 174.13% 1-Year Est. Return
PBA
Paradigm Biocapital Advisors New York $5.34B AUM 380.18% 1-Year Est. Return
Vanguard Capital Management
Vanguard Capital Management Malvern, Pennsylvania $4.68T AUM
State Street
State Street Boston, Massachusetts $3.37T AUM 44.26% 1-Year Est. Return
VA
VR Adviser New York $3.3B AUM 525.74% 1-Year Est. Return
T. Rowe Price Associates
T. Rowe Price Associates Baltimore, Maryland $999B AUM 46.22% 1-Year Est. Return
DCM
Driehaus Capital Management Chicago, Illinois $17.3B AUM 211.34% 1-Year Est. Return

Commodore Capital's SYRE Position: Q2 2026 in Review

Commodore Capital reduced its Spyre Therapeutics (SYRE) stake by 56% in Q2 2026, selling an estimated $77.8M and leaving 846,786 shares worth $75.2M. The position accounts for 4.48% of the portfolio, ranked #7.

Commodore Capital first reported a position in SYRE in Q2 2023 and has held it in 13 quarters since. The position peaked at $96.5M in Q1 2026. 265 funds tracked by Wall St. Rank hold SYRE as of Q2 2026.

  • Commodore Capital held 846,786 shares of Spyre Therapeutics worth $75.2M as of Q2 2026.
  • Commodore Capital sold 1,065,594 Spyre Therapeutics shares in Q2 2026, an estimated $77.8M.
  • Spyre Therapeutics made up 4.48% of Commodore Capital's portfolio in Q2 2026, its #7 holding.
  • Commodore Capital first reported a position in Spyre Therapeutics in Q2 2023 and has held it in 13 quarters since.
  • Commodore Capital's Spyre Therapeutics position peaked at $96.5M in Q1 2026.
  • 265 funds tracked by Wall St. Rank held Spyre Therapeutics as of Q2 2026.

Based on Commodore Capital's 13F filing for Q2 2026, filed 14 Aug 2026.