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Spyre Therapeutics
SYRE

Overview Fund Activity

127 hedge funds and large institutions have $950M invested in Spyre Therapeutics in 2025 Q2 according to their latest regulatory filings, with 18 funds opening new positions, 61 increasing their positions, 26 reducing their positions, and 17 closing their positions.

Holders
127
Holders Change
-2
Holders Change %
-1.55%
% of All Funds
1.71%
Holding in Top 10
3
Holding in Top 10 Change
+1
Holding in Top 10 Change %
+50%
% of All Funds
0.04%
New
18
Increased
61
Reduced
26
Closed
17
Calls
$1.05M
Puts
$603K
Net Calls
+$446K
Net Calls Change
+$628K

Top Buyers

1
TCM
1
Tang Capital Management
California
$47.9M
2
T. Rowe Price Associates
2
T. Rowe Price Associates
Maryland
$13.9M
3
BBA
3
Baker Bros. Advisors
New York
$9.38M
4
BlackRock
4
BlackRock
New York
$60M
5
Morgan Stanley
5
Morgan Stanley
New York
$10M

Top Sellers

1
Janus Henderson Group
1
Janus Henderson Group
United Kingdom
$194K
2
PA
2
Perceptive Advisors
New York
$22.9M
3
DCM
3
Driehaus Capital Management
Illinois
$31.2M
4
PBA
4
Paradigm Biocapital Advisors
New York
$28M
5
Adage Capital Partners
5
Adage Capital Partners
Massachusetts
$9.13M
Name Market Value Shares Shares
Change 		Shares
Change %
AAA
26
Affinity Asset Advisors
New York
$9.08M 606,678 +125,000 +26%
EA
27
Emerald Advisers
Pennsylvania
$8.47M 565,863 +18,036 +3%
Goldman Sachs
28
Goldman Sachs
New York
$7.84M 523,416 +326,348 +166%
Blackstone Inc
29
Blackstone Inc
New York
$7.32M 489,248 – –
WP
30
Woodline Partners
California
$6.96M 465,152 +344 +0.1%
UBS Group
31
UBS Group
Switzerland
$6.93M 462,863 -89,380 -16%
Northern Trust
32
Northern Trust
Illinois
$6.54M 436,947 +57,072 +15%
Charles Schwab
33
Charles Schwab
California
$6.26M 418,503 +35,867 +9%
Bank of America
34
Bank of America
North Carolina
$5.93M 396,351 -30,724 -7%
SL
35
Siren LLC
Connecticut
$5.52M 368,598 – –
Victory Capital Management
36
Victory Capital Management
Texas
$5.3M 354,116 +102,270 +41%
Capital World Investors
37
Capital World Investors
California
$5.25M 350,774 – –
EMFAT
38
Emerald Mutual Fund Advisers Trust
Pennsylvania
$4.93M 329,430 -59,992 -15%
Voloridge Investment Management
39
Voloridge Investment Management
Florida
$4.18M 278,920 +21,488 +8%
CS
40
Candriam SCA
Luxembourg
$3.68M 246,030 – –
BNP Paribas Financial Markets
41
BNP Paribas Financial Markets
France
$3.34M 223,320 +167,487 +300%
DTC
42
Deep Track Capital
Connecticut
$3.28M 219,015 – –
Barclays
43
Barclays
United Kingdom
$3.24M 216,646 +2,040 +1%
CLGM
44
Capitolis Liquid Global Markets
New York
$2.74M 183,000 +183,000 New
AC
45
Armistice Capital
New York
$2.57M 172,000 -28,000 -14%
NL
46
Nuveen LLC
North Carolina
$2.02M 135,068 -5,061 -4%
Bank of New York Mellon
47
Bank of New York Mellon
New York
$1.98M 132,150 +17,910 +16%
TD Asset Management
48
TD Asset Management
Ontario, Canada
$1.71M 113,968 +91,600 +410%
HS
49
HighVista Strategies
Massachusetts
$1.69M 112,805 +17,646 +19%
Universal-Beteiligungs- und Servicegesellschaft
50
Universal-Beteiligungs- und Servicegesellschaft
Germany
$1.64M 109,284 -11,037 -9%
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