SL
SYRE icon

Siren LLC’s Spyre Therapeutics SYRE Stock Holding History

Siren LLC’s Portfolio SYRE Stock Details SYRE Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q2 		$86M Buy
968,598
+150,000
+18% +$10.9M 1.74% 14
2026
Q1 		$41.3M Hold
818,598
– – 1.14% 24
2025
Q4 		$26.8M Buy
818,598
+450,000
+122% +$11.8M 0.8% 34
2025
Q3 		$6.18M Hold
368,598
– – 0.24% 59
2025
Q2 		$5.52M Hold
368,598
– – 0.29% 61
2025
Q1 		$5.95M Sell
368,598
-5,402
-1% -$112K 0.34% 52
2024
Q4 		$8.71M Buy
+374,000
New +$11M 0.38% 51

Other funds holding SYRE

Fidelity Investments
Fidelity Investments Boston, Massachusetts $2.3T AUM 54.33% 1-Year Est. Return
BlackRock
BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return
PA
Perceptive Advisors New York $6.66B AUM 360.84% 1-Year Est. Return
RI
RTW Investments New York $11.7B AUM 174.13% 1-Year Est. Return
PBA
Paradigm Biocapital Advisors New York $5.34B AUM 380.18% 1-Year Est. Return
Vanguard Capital Management
Vanguard Capital Management Malvern, Pennsylvania $4.68T AUM
State Street
State Street Boston, Massachusetts $3.37T AUM 44.26% 1-Year Est. Return
VA
VR Adviser New York $3.3B AUM 525.74% 1-Year Est. Return
T. Rowe Price Associates
T. Rowe Price Associates Baltimore, Maryland $999B AUM 46.22% 1-Year Est. Return
DCM
Driehaus Capital Management Chicago, Illinois $17.3B AUM 211.34% 1-Year Est. Return

Siren LLC's SYRE Position: Q2 2026 in Review

Siren LLC increased its Spyre Therapeutics (SYRE) stake by 18% in Q2 2026, buying an estimated $10.9M and bringing the position to 968,598 shares worth $86M. The position accounts for 1.74% of the portfolio, ranked #14.

Siren LLC first reported a position in SYRE in Q4 2024 and has held it in 7 quarters since. 265 funds tracked by Wall St. Rank hold SYRE as of Q2 2026.

  • Siren LLC held 968,598 shares of Spyre Therapeutics worth $86M as of Q2 2026.
  • Siren LLC bought 150,000 Spyre Therapeutics shares in Q2 2026, an estimated $10.9M.
  • Spyre Therapeutics made up 1.74% of Siren LLC's portfolio in Q2 2026, its #14 holding.
  • Siren LLC first reported a position in Spyre Therapeutics in Q4 2024 and has held it in 7 quarters since.
  • 265 funds tracked by Wall St. Rank held Spyre Therapeutics as of Q2 2026.

Based on Siren LLC's 13F filing for Q2 2026, filed 13 Aug 2026.