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SL

Siren LLC Portfolio holdings

AUM $3.61B
1-Year Est. Return 203.3%
This Fund
S&P 500
This Quarter Est. Return
1 Year Est. Return
+203.3%
3 Year Est. Return
5 Year Est. Return
10 Year Est. Return
AUM
$3.61B
AUM Growth
+$255M
Cap. Flow
Cap. Flow %
Top 10 Hldgs %
Holding
131
New
Increased
Reduced
Closed

Top Buys

1
+$75.9M
2
+$39M
3
+$32.4M
4
ERAS icon
Erasca
ERAS
+$29.4M
5
XENE icon
Xenon Pharmaceuticals
XENE
+$23.3M

Top Sells

1
+$76.1M
2
+$64.8M
3
+$50.3M
4
RAPT
RAPT Therapeutics
RAPT
+$46.6M
5
ZYME icon
Zymeworks
ZYME
+$44.2M

Sector Composition

1 Healthcare 93.63%
2 Technology 3.69%
3 Communication Services 1.71%
4 Consumer Discretionary 0.77%
5 Industrials 0.08%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
SRRK icon
1
Scholar Rock
SRRK
$5.29B
$532M 14.75%
10,825,013
KYMR icon
2
Kymera Therapeutics
KYMR
$7.09B
$265M 7.36%
3,186,830
-100,000
ERAS icon
3
Erasca
ERAS
$4.37B
$182M 5.04%
11,244,246
+2,486,997
EWTX icon
4
Edgewise Therapeutics
EWTX
$3.75B
$140M 3.87%
4,430,263
-99,727
ONC
5
BeOne Medicines Ltd
ONC
$27.4B
$138M 3.83%
465,000
-35,000
TNGX icon
6
Tango Therapeutics
TNGX
$5.04B
$118M 3.28%
5,657,105
-2,508,269
BCAX
7
Bicara Therapeutics
BCAX
$1.43B
$115M 3.2%
5,802,970
+586,001
RVMD icon
8
Revolution Medicines
RVMD
$32.7B
$108M 3%
1,110,980
-224,095
ARWR icon
9
Arrowhead Research
ARWR
$10.5B
$101M 2.81%
1,615,476
+115,000
MANE
10
Veradermics Inc
MANE
$4.01B
$95.1M 2.64%
+1,505,374
XENE icon
11
Xenon Pharmaceuticals
XENE
$5.04B
$76.7M 2.13%
1,318,564
+505,803
OLMA icon
12
Olema Pharmaceuticals
OLMA
$862M
$70.9M 1.97%
4,756,949
+1,456,249
CRNX icon
13
Crinetics Pharmaceuticals
CRNX
$3.63B
$69.1M 1.92%
1,903,636
+396,000
LXRX icon
14
Lexicon Pharmaceuticals
LXRX
$853M
$69.1M 1.92%
44,303,518
+5,384,615
COGT icon
15
Cogent Biosciences
COGT
$5.66B
$65.8M 1.82%
1,709,279
+80,000
STOK icon
16
Stoke Therapeutics
STOK
$1.86B
$65M 1.8%
1,995,347
-252,000
RCUS icon
17
Arcus Biosciences
RCUS
$2.99B
$65M 1.8%
3,007,077
GPCR icon
18
Structure Therapeutics
GPCR
$3.05B
$64M 1.78%
1,328,698
+250,000
IRON icon
19
Disc Medicine
IRON
$2.6B
$63.2M 1.75%
988,401
RYTM icon
20
Rhythm Pharmaceuticals
RYTM
$6.06B
$63.1M 1.75%
725,511
+225,536
SLDB icon
21
Solid Biosciences
SLDB
$703M
$55.4M 1.53%
7,690,405
SEPN
22
Septerna Inc
SEPN
$1.62B
$48.1M 1.33%
2,000,000
CNTA
23
Centessa Pharmaceuticals
CNTA
$6.15B
$41.8M 1.16%
1,053,464
-2,974,053
SYRE icon
24
Spyre Therapeutics
SYRE
$7.02B
$41.3M 1.14%
818,598
CYTK icon
25
Cytokinetics
CYTK
$9.52B
$40.5M 1.12%
+613,952
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