SL
Siren LLC Portfolio holdings
AUM
$1.93B
This Quarter Return
+18.65%
1 Year Return
+118.08%
3 Year Return
–
5 Year Return
–
10 Year Return
–
AUM
$1.93B
AUM Growth
+$1.93B
(+9%)
Cap. Flow
-$12.9M
Cap. Flow
% of AUM
-0.67%
Top 10 Holdings %
Top 10 Hldgs %
48.49%
Holding
131
New
15
Increased
21
Reduced
19
Closed
21
Top Buys
| 1 |
MoonLake Immunotherapeutics
MLTX
|
$24M |
| 2 |
Dyne Therapeutics
DYN
|
$20.2M |
| 3 |
Edgewise Therapeutics
EWTX
|
$19.2M |
| 4 |
BCAX
Bicara Therapeutics Inc. Common Stock
BCAX
|
$18.1M |
| 5 |
Akero Therapeutics
AKRO
|
$17M |
Top Sells
| 1 |
BPMC
Blueprint Medicines
BPMC
|
$64.3M |
| 2 |
Soleno Therapeutics
SLNO
|
$21.8M |
| 3 |
Prothena Corp
PRTA
|
$15.9M |
| 4 |
Summit Therapeutics
SMMT
|
$13.4M |
| 5 |
NewAmsterdam Pharma
NAMS
|
$13M |
Sector Composition
| 1 | Healthcare | 90.42% |
| 2 | Technology | 4.93% |
| 3 | Communication Services | 2.51% |
| 4 | Consumer Discretionary | 1.07% |
| 5 | Real Estate | 0.77% |
| Name | Market Value | Portfolio Weight | Shares or Principal |
Shares Change % | Capital Flow | |
|---|---|---|---|---|---|---|
1
Scholar Rock
SRRK
$3.18B
| $328M | 16.95% |
9,250,005
| – | – |
|
2
Kymera Therapeutics
KYMR
$2.91B
| $150M | 7.74% |
3,428,150
+187,837
| +6% | +$8.2M |
|
|
ONC
3
BeOne Medicines Ltd. American Depositary Shares
ONC
$36.5B
| $123M | 6.39% |
509,990
+11,301
| +2% | +$2.74M |
|
4
Disc Medicine
IRON
$2.07B
| $58.2M | 3.01% |
1,099,401
+27,536
| +3% | +$1.46M |
|
5
Crinetics Pharmaceuticals
CRNX
$3.14B
| $48.6M | 2.51% |
1,688,611
| – | – |
|
|
BCAX
6
Bicara Therapeutics Inc. Common Stock
BCAX
$649M
| $48.5M | 2.51% |
5,216,969
+1,949,886
| +60% | +$18.1M |
|
|
7
Dyne Therapeutics
DYN
$1.92B
| $46M | 2.38% |
4,836,437
+2,118,450
| +78% | +$20.2M |
|
|
CNTA
8
Centessa Pharmaceuticals
CNTA
$2.32B
| $45.5M | 2.35% |
3,460,029
+500,000
| +17% | +$6.57M |
|
9
Merus
MRUS
$5.01B
| $44.9M | 2.32% |
853,467
-190,000
| -18% | -$9.99M |
|
10
Apellis Pharmaceuticals
APLS
$3.48B
| $44.6M | 2.31% |
2,578,396
| – | – |
|
11
Ascendis Pharma
ASND
$11.8B
| $42.4M | 2.2% |
245,943
-41,423
| -14% | -$7.15M |
|
12
Arrowhead Research
ARWR
$3.55B
| $42.2M | 2.18% |
2,669,880
| – | – |
|
|
13
Edgewise Therapeutics
EWTX
$1.57B
| $41.4M | 2.14% |
3,160,298
+1,463,854
| +86% | +$19.2M |
|
|
14
Soleno Therapeutics
SLNO
$3.57B
| $39.2M | 2.03% |
467,342
-259,995
| -36% | -$21.8M |
|
15
Lexicon Pharmaceuticals
LXRX
$407M
| $36.8M | 1.9% |
38,918,903
| – | – |
|
16
Taboola.com
TBLA
$991M
| $36.5M | 1.89% |
9,969,495
| – | – |
|
17
Solid Biosciences
SLDB
$423M
| $36.1M | 1.87% |
7,415,905
| – | – |
|
18
Revolution Medicines
RVMD
$7.39B
| $34.5M | 1.79% |
938,755
+375,000
| +67% | +$13.8M |
|
19
Avidity Biosciences
RNA
$6.08B
| $31.5M | 1.63% |
1,110,610
| – | – |
|
20
Rhythm Pharmaceuticals
RYTM
$6.92B
| $25.9M | 1.34% |
409,742
+132,209
| +48% | +$8.35M |
|
21
Apogee Therapeutics
APGE
$2.26B
| $25.8M | 1.34% |
594,994
| – | – |
|
22
Stoke Therapeutics
STOK
$1.07B
| $25.5M | 1.32% |
2,247,347
| – | – |
|
23
Taysha Gene Therapies
TSHA
$775M
| $25.4M | 1.32% |
11,014,737
+4,500,000
| +69% | +$10.4M |
|
24
Xenon Pharmaceuticals
XENE
$3.03B
| $25.4M | 1.32% |
812,761
+80,000
| +11% | +$2.5M |
|
25
Wave Life Sciences
WVE
$1.53B
| $24M | 1.24% |
3,696,322
| – | – |
|