Siren LLC Portfolio holdings

AUM $1.77B

This Quarter Return

-13.7%

1 Year Return

–

3 Year Return

–

5 Year Return

–

10 Year Return

–

AUM

$1.77B

AUM Growth

-$491M (-22%)

Cap. Flow

-$54.5M

Cap. Flow % of AUM

-3.08%

Top 10 Holdings %Top 10 Hldgs %

50.37%

Holding

140

New

Increased

Reduced

Closed

Top Buys

1	Blueprint Medicines BPMC	$64.3M
2	Disc Medicine IRON	$53.2M
3	Soleno Therapeutics SLNO	$26.8M
4	Edgewise Therapeutics EWTX	$21.2M
5	Rhythm Pharmaceuticals RYTM	$14.7M

Top Sells

1	argenx ARGX	$70.8M
2	KLRS Kalaris Therapeutics, Inc. Common Stock KLRS	$50.7M
3	SWTX SpringWorks Therapeutics SWTX	$49.8M
4	ONC BeOne Medicines Ltd. American Depositary Shares ONC	$42.2M
5	Madrigal Pharmaceuticals MDGL	$38.9M

Sector Composition

1	Healthcare	89.75%
2	Technology	5.2%
3	Communication Services	2.41%
4	Consumer Discretionary	1.21%
5	Real Estate	0.81%

#	Name	Market Value	Portfolio Weight	Shares or Principal	Shares Change %	Capital Flow
1	1 Scholar Rock SRRK $3.87B	$297M	16.78%	9,250,005	–	–
2	ONC 2 BeOne Medicines Ltd. American Depositary Shares ONC $31.9B	$136M	7.66%	498,689 -155,032	-24%	-$42.2M
3	3 Kymera Therapeutics KYMR $3.24B	$88.7M	5%	3,240,313 +270,580	+9%	+$7.41M
4	4 Blueprint Medicines BPMC $8.36B	$64.3M	3.63%	+726,167	New	+$64.3M
5	5 Crinetics Pharmaceuticals CRNX $2.91B	$56.6M	3.19%	1,688,611 +78,959	+5%	+$2.65M
6	6 Apellis Pharmaceuticals APLS $2.45B	$56.4M	3.18%	2,578,396 -237,862	-8%	-$5.2M
7	7 Disc Medicine IRON $2B	$53.2M	3%	+1,071,865	New	+$53.2M
8	8 Soleno Therapeutics SLNO $4.6B	$52M	2.93%	727,337 +375,519	+107%	+$26.8M
9	9 Ascendis Pharma ASND $10.3B	$44.8M	2.53%	287,366 -9,955	-3%	-$1.55M
10	10 Merus MRUS $4.71B	$43.9M	2.48%	1,043,467 +259,055	+33%	+$10.9M
11	BCAX 11 Bicara Therapeutics Inc. Common Stock BCAX $596M	$42.6M	2.4%	3,267,083 -5,744	-0.2%	-$74.8K
12	CNTA 12 Centessa Pharmaceuticals CNTA $2.1B	$42.6M	2.4%	2,960,029 -44,648	-1%	-$642K
13	13 NewAmsterdam Pharma NAMS $2.49B	$39.1M	2.21%	1,912,030 -183,608	-9%	-$3.76M
14	14 Edgewise Therapeutics EWTX $1.42B	$37.3M	2.11%	1,696,444 +962,101	+131%	+$21.2M
15	15 Arrowhead Research ARWR $2.31B	$34M	1.92%	2,669,880 -231,801	-8%	-$2.95M
16	16 Avidity Biosciences RNA $4.07B	$32.8M	1.85%	1,110,610 -16,685	-1%	-$493K
17	17 Wave Life Sciences WVE $1.3B	$29.9M	1.68%	3,696,322 -54,169	-1%	-$438K
18	18 Taboola.com TBLA $1.14B	$29.4M	1.66%	9,969,495	–	–
19	19 Dyne Therapeutics DYN $1.28B	$28.4M	1.6%	2,717,987 +1,370,531	+102%	+$14.3M
20	20 Solid Biosciences SLDB $495M	$27.4M	1.55%	7,415,905 +3,666,864	+98%	+$13.6M
21	21 Xenon Pharmaceuticals XENE $2.42B	$24.6M	1.39%	732,761 -11,008	-1%	-$369K
22	22 Apogee Therapeutics APGE $2.29B	$22.2M	1.25%	594,994 -152,331	-20%	-$5.69M
23	23 Revolution Medicines RVMD $7.13B	$19.9M	1.12%	563,755 -7,793	-1%	-$276K
24	24 Trevi Therapeutics TRVI $835M	$18M	1.02%	2,863,793 -42,267	-1%	-$266K
25	25 Vera Therapeutics VERA $1.47B	$17.9M	1.01%	747,216 -11,249	-1%	-$270K