SL

Siren LLC Portfolio holdings

AUM $3.35B
1-Year Est. Return 103.4%
This Fund
S&P 500
This Quarter Est. Return
1 Year Est. Return
+103.4%
3 Year Est. Return
5 Year Est. Return
10 Year Est. Return
AUM
$3.35B
AUM Growth
+$796M
Cap. Flow
Cap. Flow %
Top 10 Hldgs %
Holding
141
New
Increased
Reduced
Closed

Top Buys

1
+$82.5M
2
+$69.4M
3
+$44.2M
4
DBVT
DBV Technologies
DBVT
+$35.6M
5
ENGN icon
enGene Holdings
ENGN
+$30.1M

Top Sells

1
+$77.6M
2
+$56M
3
+$45.8M
4
SLNO icon
Soleno Therapeutics
SLNO
+$31.6M
5
DYN icon
Dyne Therapeutics
DYN
+$24M

Sector Composition

1 Healthcare 93.02%
2 Technology 3.72%
3 Communication Services 1.9%
4 Real Estate 0.59%
5 Consumer Discretionary 0.59%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
SRRK icon
1
Scholar Rock
SRRK
$4.69B
$477M 14.22%
10,825,013
+1,575,008
KYMR icon
2
Kymera Therapeutics
KYMR
$6.59B
$256M 7.63%
3,286,830
-141,320
ONC
3
BeOne Medicines Ltd
ONC
$38.3B
$152M 4.53%
500,000
+7,010
EWTX icon
4
Edgewise Therapeutics
EWTX
$3.18B
$112M 3.35%
4,529,990
+632,891
RVMD icon
5
Revolution Medicines
RVMD
$18.6B
$106M 3.17%
1,335,075
+291,355
CNTA
6
Centessa Pharmaceuticals
CNTA
$3.65B
$101M 3%
4,027,517
+800,000
ARWR icon
7
Arrowhead Research
ARWR
$8.94B
$99.6M 2.97%
1,500,476
-1,169,404
BCAX
8
Bicara Therapeutics
BCAX
$778M
$87.8M 2.62%
5,216,969
OLMA icon
9
Olema Pharmaceuticals
OLMA
$1.81B
$82.5M 2.46%
+3,300,700
IRON icon
10
Disc Medicine
IRON
$2.11B
$78.5M 2.34%
988,401
+75,000
GPCR icon
11
Structure Therapeutics
GPCR
$4.95B
$75M 2.24%
1,078,698
+51,887
TNGX icon
12
Tango Therapeutics
TNGX
$1.74B
$72.3M 2.16%
8,165,374
+2,282,186
RCUS icon
13
Arcus Biosciences
RCUS
$2.34B
$71.7M 2.14%
3,007,077
+95,000
STOK icon
14
Stoke Therapeutics
STOK
$1.82B
$71.3M 2.13%
2,247,347
CRNX icon
15
Crinetics Pharmaceuticals
CRNX
$4.38B
$70.2M 2.09%
1,507,636
-180,975
DYN icon
16
Dyne Therapeutics
DYN
$2.56B
$68.5M 2.04%
3,502,941
-1,226,233
APLS icon
17
Apellis Pharmaceuticals
APLS
$2.75B
$64.8M 1.93%
2,578,396
COGT icon
18
Cogent Biosciences
COGT
$5.61B
$57.9M 1.73%
1,629,279
-95,000
SEPN
19
Septerna Inc
SEPN
$1.23B
$55.8M 1.66%
2,000,000
-202,514
TSHA icon
20
Taysha Gene Therapies
TSHA
$1.25B
$55.7M 1.66%
10,129,913
-884,824
RYTM icon
21
Rhythm Pharmaceuticals
RYTM
$6.54B
$53.5M 1.6%
499,975
ASND icon
22
Ascendis Pharma
ASND
$13.3B
$50.3M 1.5%
235,862
RAPT icon
23
RAPT Therapeutics
RAPT
$1.67B
$46.6M 1.39%
1,375,000
+794,534
TBLA icon
24
Taboola.com
TBLA
$968M
$46M 1.37%
9,969,495
LXRX icon
25
Lexicon Pharmaceuticals
LXRX
$547M
$44.8M 1.34%
38,918,903
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