SL

Siren LLC Portfolio holdings

AUM $1.93B
1-Year Est. Return 118.08%
This Quarter Est. Return
1 Year Est. Return
+118.08%
3 Year Est. Return
5 Year Est. Return
10 Year Est. Return
AUM
$1.93B
AUM Growth
+$160M
Cap. Flow
Cap. Flow %
Top 10 Hldgs %
Holding
131
New
Increased
Reduced
Closed

Top Buys

1
+$24M
2
+$20.2M
3
+$19.2M
4
BCAX
Bicara Therapeutics
BCAX
+$18.1M
5
AKRO icon
Akero Therapeutics
AKRO
+$17M

Top Sells

1
+$64.3M
2
+$21.8M
3
+$15.9M
4
SMMT icon
Summit Therapeutics
SMMT
+$13.4M
5
NAMS icon
NewAmsterdam Pharma
NAMS
+$13M

Sector Composition

1 Healthcare 90.42%
2 Technology 4.93%
3 Communication Services 2.51%
4 Consumer Discretionary 1.07%
5 Real Estate 0.77%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
SRRK icon
1
Scholar Rock
SRRK
$2.86B
$328M 16.95%
9,250,005
KYMR icon
2
Kymera Therapeutics
KYMR
$4.36B
$150M 7.74%
3,428,150
+187,837
ONC
3
BeOne Medicines Ltd
ONC
$34.7B
$123M 6.39%
509,990
+11,301
IRON icon
4
Disc Medicine
IRON
$3.29B
$58.2M 3.01%
1,099,401
+27,536
CRNX icon
5
Crinetics Pharmaceuticals
CRNX
$4.08B
$48.6M 2.51%
1,688,611
BCAX
6
Bicara Therapeutics
BCAX
$942M
$48.5M 2.51%
5,216,969
+1,949,886
DYN icon
7
Dyne Therapeutics
DYN
$3.52B
$46M 2.38%
4,836,437
+2,118,450
CNTA
8
Centessa Pharmaceuticals
CNTA
$3.35B
$45.5M 2.35%
3,460,029
+500,000
MRUS icon
9
Merus
MRUS
$7.19B
$44.9M 2.32%
853,467
-190,000
APLS icon
10
Apellis Pharmaceuticals
APLS
$3.81B
$44.6M 2.31%
2,578,396
ASND icon
11
Ascendis Pharma
ASND
$12.5B
$42.4M 2.2%
245,943
-41,423
ARWR icon
12
Arrowhead Research
ARWR
$5.47B
$42.2M 2.18%
2,669,880
EWTX icon
13
Edgewise Therapeutics
EWTX
$1.72B
$41.4M 2.14%
3,160,298
+1,463,854
SLNO icon
14
Soleno Therapeutics
SLNO
$3.61B
$39.2M 2.03%
467,342
-259,995
LXRX icon
15
Lexicon Pharmaceuticals
LXRX
$501M
$36.8M 1.9%
38,918,903
TBLA icon
16
Taboola.com
TBLA
$1.04B
$36.5M 1.89%
9,969,495
SLDB icon
17
Solid Biosciences
SLDB
$465M
$36.1M 1.87%
7,415,905
RVMD icon
18
Revolution Medicines
RVMD
$10.9B
$34.5M 1.79%
938,755
+375,000
RNA icon
19
Avidity Biosciences
RNA
$10.2B
$31.5M 1.63%
1,110,610
RYTM icon
20
Rhythm Pharmaceuticals
RYTM
$7.49B
$25.9M 1.34%
409,742
+132,209
APGE icon
21
Apogee Therapeutics
APGE
$3.83B
$25.8M 1.34%
594,994
STOK icon
22
Stoke Therapeutics
STOK
$1.8B
$25.5M 1.32%
2,247,347
TSHA icon
23
Taysha Gene Therapies
TSHA
$1.36B
$25.4M 1.32%
11,014,737
+4,500,000
XENE icon
24
Xenon Pharmaceuticals
XENE
$3.26B
$25.4M 1.32%
812,761
+80,000
WVE icon
25
Wave Life Sciences
WVE
$1.23B
$24M 1.24%
3,696,322
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