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Siren LLC’s Structure Therapeutics GPCR Stock Holding History

Siren LLC’s Portfolio GPCR Stock Details GPCR Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q2 		$46.9M Sell
872,967
-455,731
-34% -$20.2M 0.95% 33
2026
Q1 		$64M Buy
1,328,698
+250,000
+23% +$17.1M 1.78% 18
2025
Q4 		$75M Buy
1,078,698
+51,887
+5% +$2.12M 2.24% 11
2025
Q3 		$28.8M Buy
+1,026,811
New +$20.5M 1.12% 28

Other funds holding GPCR

Fidelity Investments
Fidelity Investments Boston, Massachusetts $2.3T AUM 54.33% 1-Year Est. Return
Wellington Management Group
Wellington Management Group Boston, Massachusetts $580B AUM 38.23% 1-Year Est. Return
ACA
Avoro Capital Advisors New York $11.1B AUM 207.82% 1-Year Est. Return
JT
Jupiter Topco New York $245B AUM
DTC
Deep Track Capital Greenwich, Connecticut $6.87B AUM 205.24% 1-Year Est. Return
BI
BVF Inc San Francisco, California $3.91B AUM 304.52% 1-Year Est. Return
Morgan Stanley
Morgan Stanley New York $1.89T AUM 35.08% 1-Year Est. Return
O
OrbiMed New York $5.4B AUM 163.13% 1-Year Est. Return
Principal Financial Group
Principal Financial Group Des Moines, Iowa $204B AUM 27.99% 1-Year Est. Return
American Century Companies
American Century Companies Kansas City, Missouri $226B AUM 44.75% 1-Year Est. Return

Siren LLC's GPCR Position: Q2 2026 in Review

Siren LLC reduced its Structure Therapeutics (GPCR) stake by 34% in Q2 2026, selling an estimated $20.2M and leaving 872,967 shares worth $46.9M. The position accounts for 0.95% of the portfolio, ranked #33.

Siren LLC first reported a position in GPCR in Q3 2025 and has held it in 4 quarters since. The position peaked at $75M in Q4 2025. 192 funds tracked by Wall St. Rank hold GPCR as of Q2 2026.

  • Siren LLC held 872,967 shares of Structure Therapeutics worth $46.9M as of Q2 2026.
  • Siren LLC sold 455,731 Structure Therapeutics shares in Q2 2026, an estimated $20.2M.
  • Structure Therapeutics made up 0.95% of Siren LLC's portfolio in Q2 2026, its #33 holding.
  • Siren LLC first reported a position in Structure Therapeutics in Q3 2025 and has held it in 4 quarters since.
  • Siren LLC's Structure Therapeutics position peaked at $75M in Q4 2025.
  • 192 funds tracked by Wall St. Rank held Structure Therapeutics as of Q2 2026.

Based on Siren LLC's 13F filing for Q2 2026, filed 13 Aug 2026.