Siren LLC Portfolio holdings

AUM $1.77B

This Quarter Return

-13.7%

1 Year Return

–

3 Year Return

–

5 Year Return

–

10 Year Return

–

AUM

$1.77B

AUM Growth

-$491M (-22%)

Cap. Flow

-$54.5M

Cap. Flow % of AUM

-3.08%

Top 10 Holdings %Top 10 Hldgs %

50.37%

Holding

140

New

Increased

Reduced

Closed

Top Buys

1	Blueprint Medicines BPMC	$64.3M
2	Disc Medicine IRON	$53.2M
3	Soleno Therapeutics SLNO	$26.8M
4	Edgewise Therapeutics EWTX	$21.2M
5	Rhythm Pharmaceuticals RYTM	$14.7M

Top Sells

1	argenx ARGX	$70.8M
2	KLRS Kalaris Therapeutics, Inc. Common Stock KLRS	$50.7M
3	SWTX SpringWorks Therapeutics SWTX	$49.8M
4	ONC BeOne Medicines Ltd. American Depositary Shares ONC	$42.2M
5	Madrigal Pharmaceuticals MDGL	$38.9M

Sector Composition

1	Healthcare	89.75%
2	Technology	5.2%
3	Communication Services	2.41%
4	Consumer Discretionary	1.21%
5	Real Estate	0.81%

#	Name	Market Value	Portfolio Weight	Shares or Principal	Shares Change %	Capital Flow
26	26 Lexicon Pharmaceuticals LXRX $447M	$17.9M	1.01%	38,918,903	–	–
27	27 Prothena Corp PRTA $337M	$15.9M	0.9%	1,283,555 +183,715	+17%	+$2.27M
28	BCYC 28 Bicycle Therapeutics BCYC $593M	$15.4M	0.87%	1,812,752 -26,646	-1%	-$226K
29	29 Stoke Therapeutics STOK $722M	$14.9M	0.84%	2,247,347 +247,347	+12%	+$1.64M
30	30 Rhythm Pharmaceuticals RYTM $5.89B	$14.7M	0.83%	+277,533	New	+$14.7M
31	31 Summit Therapeutics SMMT $19.5B	$13.4M	0.76%	+695,000	New	+$13.4M
32	SEPN 32 Septerna, Inc. Common Stock SEPN $559M	$12.8M	0.72%	2,202,514	–	–
33	33 Arcus Biosciences RCUS $969M	$12.7M	0.71%	1,612,077	–	–
34	34 IHS Holding IHS $1.98B	$12.3M	0.69%	2,357,520	–	–
35	35 Erasca ERAS $425M	$12M	0.68%	8,757,249 -99,930	-1%	-$137K
36	36 Denali Therapeutics DNLI $2.03B	$11.2M	0.63%	821,513 -12,515	-2%	-$170K
37	37 Vaxcyte PCVX $4.67B	$11.2M	0.63%	295,543 -4,448	-1%	-$168K
38	38 Amazon AMZN $2.4T	$10.7M	0.61%	56,500 +20,000	+55%	+$3.81M
39	39 Microsoft MSFT $3.79T	$10.7M	0.6%	28,500 +5,500	+24%	+$2.06M
40	40 Remitly RELY $3.47B	$10.2M	0.58%	490,449	–	–
41	41 Taysha Gene Therapies TSHA $672M	$9.06M	0.51%	6,514,737 -87,738	-1%	-$122K
42	42 Cullinan Oncology CGEM $444M	$9.03M	0.51%	1,193,410 -17,947	-1%	-$136K
43	43 CrowdStrike CRWD $119B	$8.81M	0.5%	25,000 +1,000	+4%	+$353K
44	SLN 44 Silence Therapeutics SLN $285M	$7.87M	0.44%	2,789,833 -41,937	-1%	-$118K
45	45 Alphabet (Google) Class A GOOGL $2.25T	$7.84M	0.44%	50,703 +43,703	+624%	+$6.76M
46	46 Cartesian Therapeutics RNAC $307M	$7.42M	0.42%	563,272 -8,964	-2%	-$118K
47	47 Adobe ADBE $155B	$7.4M	0.42%	19,298 +10,500	+119%	+$4.03M
48	48 Korro Bio KRRO $128M	$7.29M	0.41%	418,833	–	–
49	49 ServiceNow NOW $200B	$7.27M	0.41%	9,126 +3,521	+63%	+$2.8M
50	50 Seer Inc SEER $124M	$6.76M	0.38%	4,000,000	–	–