SL

Siren LLC Portfolio holdings

AUM $3.35B
1-Year Est. Return 103.36%
This Fund
S&P 500
This Quarter Est. Return
1 Year Est. Return
+103.36%
3 Year Est. Return
5 Year Est. Return
10 Year Est. Return
AUM
$3.35B
AUM Growth
+$796M
Cap. Flow
Cap. Flow %
Top 10 Hldgs %
Holding
141
New
Increased
Reduced
Closed

Top Buys

1
+$59.1M
2
+$58.7M
3
+$36.6M
4
DBVT
DBV Technologies
DBVT
+$29M
5
MLYS icon
Mineralys Therapeutics
MLYS
+$28.1M

Top Sells

1
+$57.3M
2
+$56M
3
+$45.8M
4
SLNO icon
Soleno Therapeutics
SLNO
+$31.6M
5
DYN icon
Dyne Therapeutics
DYN
+$23.2M

Sector Composition

1 Healthcare 93.02%
2 Technology 3.72%
3 Communication Services 1.9%
4 Real Estate 0.59%
5 Consumer Discretionary 0.59%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
ZYME icon
26
Zymeworks
ZYME
$1.87B
$44.2M 1.32%
+1,680,121
SLDB icon
27
Solid Biosciences
SLDB
$437M
$43.4M 1.29%
7,690,405
+274,500
WVE icon
28
Wave Life Sciences
WVE
$2.48B
$41.6M 1.24%
2,450,000
-1,246,322
XENE icon
29
Xenon Pharmaceuticals
XENE
$3.25B
$36.4M 1.09%
812,761
DBVT
30
DBV Technologies
DBVT
$1.21B
$35.6M 1.06%
+1,857,362
ERAS icon
31
Erasca
ERAS
$4.81B
$32.6M 0.97%
8,757,249
ENGN icon
32
enGene Holdings
ENGN
$583M
$30.1M 0.9%
+3,336,264
TRVI icon
33
Trevi Therapeutics
TRVI
$1.68B
$28.6M 0.85%
2,286,867
-250,000
SYRE icon
34
Spyre Therapeutics
SYRE
$3.19B
$26.8M 0.8%
818,598
+450,000
MLYS icon
35
Mineralys Therapeutics
MLYS
$2.11B
$25.4M 0.76%
+699,999
DNLI icon
36
Denali Therapeutics
DNLI
$3.08B
$23.1M 0.69%
1,396,513
+575,000
RELY icon
37
Remitly
RELY
$3.65B
$22.3M 0.67%
1,618,271
FULC icon
38
Fulcrum Therapeutics
FULC
$543M
$22.1M 0.66%
+1,950,000
RAPP
39
Rapport Therapeutics
RAPP
$1.41B
$21.5M 0.64%
708,469
-345,000
SLN
40
Silence Therapeutics
SLN
$260M
$17.7M 0.53%
2,911,438
IHS icon
41
IHS Holding
IHS
$2.71B
$17.6M 0.52%
2,357,520
GOSS icon
42
Gossamer Bio
GOSS
$121M
$16.1M 0.48%
5,208,968
UPB
43
Upstream Bio Inc
UPB
$414M
$16M 0.48%
588,450
-200,000
BCYC
44
Bicycle Therapeutics
BCYC
$371M
$14.3M 0.43%
2,012,752
MNPR icon
45
Monopar Therapeutics
MNPR
$373M
$13.9M 0.41%
+212,298
CGEM icon
46
Cullinan Oncology
CGEM
$922M
$12.4M 0.37%
1,193,410
SION
47
Sionna Therapeutics
SION
$1.54B
$12.3M 0.37%
300,000
-25,000
IKT icon
48
Inhibikase Therapeutics
IKT
$229M
$12M 0.36%
+5,850,000
NBP
49
NovaBridge Biosciences American Depositary Shares
NBP
$420M
$11.9M 0.36%
3,000,000
+1,834,043
AMZN icon
50
Amazon
AMZN
$2.35T
$11.9M 0.35%
51,500
-7,000
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