SL

Siren LLC Portfolio holdings

AUM $3.35B
1-Year Est. Return 103.36%
This Fund
S&P 500
This Quarter Est. Return
1 Year Est. Return
+103.36%
3 Year Est. Return
5 Year Est. Return
10 Year Est. Return
AUM
$2.56B
AUM Growth
+$624M
Cap. Flow
Cap. Flow %
Top 10 Hldgs %
Holding
133
New
Increased
Reduced
Closed

Top Buys

1
+$32.4M
2
+$20.5M
3
+$19.8M
4
TNGX icon
Tango Therapeutics
TNGX
+$17M
5
RCUS icon
Arcus Biosciences
RCUS
+$13.5M

Top Sells

1
+$44.9M
2
+$25.8M
3
+$24M
4
AKRO
Akero Therapeutics
AKRO
+$17M
5
IRON icon
Disc Medicine
IRON
+$11.1M

Sector Composition

1 Healthcare 91.03%
2 Technology 5.1%
3 Communication Services 1.94%
4 Consumer Discretionary 0.86%
5 Real Estate 0.74%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
SRRK icon
1
Scholar Rock
SRRK
$5.53B
$344M 13.48%
9,250,005
KYMR icon
2
Kymera Therapeutics
KYMR
$6.64B
$194M 7.59%
3,428,150
ONC
3
BeOne Medicines Ltd
ONC
$32.8B
$168M 6.57%
492,990
-17,000
ARWR icon
4
Arrowhead Research
ARWR
$10.5B
$92.1M 3.6%
2,669,880
BCAX
5
Bicara Therapeutics
BCAX
$1.42B
$82.4M 3.22%
5,216,969
CNTA
6
Centessa Pharmaceuticals
CNTA
$6.12B
$78.3M 3.06%
3,227,517
-232,512
CRNX icon
7
Crinetics Pharmaceuticals
CRNX
$4.11B
$70.3M 2.75%
1,688,611
EWTX icon
8
Edgewise Therapeutics
EWTX
$3.29B
$63.2M 2.47%
3,897,099
+736,801
IRON icon
9
Disc Medicine
IRON
$2.56B
$60.4M 2.36%
913,401
-186,000
DYN icon
10
Dyne Therapeutics
DYN
$2.87B
$59.8M 2.34%
4,729,174
-107,263
APLS icon
11
Apellis Pharmaceuticals
APLS
$5.24B
$58.3M 2.28%
2,578,396
RNAM
12
DELISTED
Avidity Biosciences
RNAM
$56M 2.19%
1,285,610
+175,000
STOK icon
13
Stoke Therapeutics
STOK
$1.96B
$52.8M 2.07%
2,247,347
LXRX icon
14
Lexicon Pharmaceuticals
LXRX
$724M
$52.5M 2.06%
38,918,903
RYTM icon
15
Rhythm Pharmaceuticals
RYTM
$5.61B
$50.5M 1.98%
499,975
+90,233
TNGX icon
16
Tango Therapeutics
TNGX
$3.03B
$49.4M 1.93%
5,883,188
+2,518,374
RVMD icon
17
Revolution Medicines
RVMD
$29.7B
$48.7M 1.91%
1,043,720
+104,965
ASND icon
18
Ascendis Pharma A/S
ASND
$13.6B
$46.9M 1.83%
235,862
-10,081
RZLT icon
19
Rezolute
RZLT
$316M
$45.8M 1.79%
+4,870,000
SLDB icon
20
Solid Biosciences
SLDB
$702M
$45.8M 1.79%
7,415,905
SEPN
21
Septerna Inc
SEPN
$1.06B
$41.4M 1.62%
2,202,514
RCUS icon
22
Arcus Biosciences
RCUS
$3.23B
$39.6M 1.55%
2,912,077
+1,300,000
TSHA icon
23
Taysha Gene Therapies
TSHA
$1.82B
$36M 1.41%
11,014,737
TBLA icon
24
Taboola.com
TBLA
$1.05B
$34M 1.33%
9,969,495
XENE icon
25
Xenon Pharmaceuticals
XENE
$5.42B
$32.6M 1.28%
812,761
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