SL
SEPN

Siren LLC’s Septerna Inc SEPN Stock Holding History

Siren LLC’s Portfolio SEPN Stock Details SEPN Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		$48.1M Hold
2,000,000
– – 1.33% 22
2025
Q4 		$55.8M Sell
2,000,000
-202,514
-9% -$4.84M 1.66% 19
2025
Q3 		$41.4M Hold
2,202,514
– – 1.62% 21
2025
Q2 		$23.3M Hold
2,202,514
– – 1.2% 27
2025
Q1 		$12.8M Hold
2,202,514
– – 0.72% 32
2024
Q4 		$50.4M Buy
+2,202,514
New +$52.1M 2.23% 10

Other funds holding SEPN

RCM
RA Capital Management Boston, Massachusetts $9.44B AUM 157.3% 1-Year Est. Return
TGV
TRV GP V Boston, Massachusetts $401M AUM 284.76% 1-Year Est. Return
DCM
Driehaus Capital Management Chicago, Illinois $13.6B AUM 173.98% 1-Year Est. Return
TGV
TRV GP VI Boston, Massachusetts $136M AUM 328.39% 1-Year Est. Return
SB
Samsara BioCapital Palo Alto, California $1.03B AUM 214.94% 1-Year Est. Return
Goldman Sachs
Goldman Sachs New York $871B AUM 31.28% 1-Year Est. Return
BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
BI
BVF Inc San Francisco, California $3.14B AUM 249.53% 1-Year Est. Return
ACA
Avoro Capital Advisors New York $10.2B AUM 149.19% 1-Year Est. Return
VCM
Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM

Siren LLC's SEPN Position: Q1 2026 in Review

Siren LLC held its Septerna Inc (SEPN) position steady in Q1 2026 at 2,000,000 shares worth $48.1M. The position accounts for 1.33% of the portfolio, ranked #22.

Siren LLC first reported a position in SEPN in Q4 2024 and has held it in 6 quarters since. The position peaked at $55.8M in Q4 2025. 124 funds tracked by Wall St. Rank hold SEPN as of Q1 2026.

  • Siren LLC held 2,000,000 shares of Septerna Inc worth $48.1M as of Q1 2026.
  • Siren LLC left its Septerna Inc share count unchanged in Q1 2026.
  • Septerna Inc made up 1.33% of Siren LLC's portfolio in Q1 2026, its #22 holding.
  • Siren LLC first reported a position in Septerna Inc in Q4 2024 and has held it in 6 quarters since.
  • Siren LLC's Septerna Inc position peaked at $55.8M in Q4 2025.
  • 124 funds tracked by Wall St. Rank held Septerna Inc as of Q1 2026.

Based on Siren LLC's 13F filing for Q1 2026, filed 14 May 2026.