Septerna Inc
SEPN
124 hedge funds and large institutions have $1.1B invested in Septerna Inc in 2026 Q1 according to their latest regulatory filings, with 28 funds opening new positions, 43 increasing their positions, 30 reducing their positions, and 24 closing their positions.
43% more repeat investments, than reductions
Existing positions increased: 43 | Existing positions reduced: 30
17% more first-time investments, than exits
New positions opened: 28 | Existing positions closed: 24
2% more funds holding
Funds holding: 122 → 124 (+2)
0% less ownership
Funds ownership: 101.82% → 101.82% (-0%)
14% less capital invested
Capital invested by funds: $1.27B → $1.1B (-$172M)
20% less funds holding in top 10
Funds holding in top 10: 5 → 4 (-1)
Top Buyers
| 1 |
Janus Henderson Group
London,
United Kingdom
|
+$23.4M |
| 2 |
Primecap Management
Pasadena,
California
|
+$13.2M |
| 3 |
Balyasny Asset Management
Chicago,
Illinois
|
+$6.13M |
| 4 |
Goldman Sachs
New York
|
+$5.03M |
| 5 |
FLAM
First Light Asset Management
Edina,
Minnesota
|
+$2.95M |
Top Sellers
| 1 |
PA
Perceptive Advisors
New York
|
-$12.1M |
| 2 |
DCM
Driehaus Capital Management
Chicago,
Illinois
|
-$10.9M |
| 3 |
WP
Woodline Partners
San Francisco,
California
|
-$10.7M |
| 4 |
BI
BVF Inc
San Francisco,
California
|
-$9.66M |
| 5 |
Marshall Wace
London,
United Kingdom
|
-$4.92M |
SEPN Hedge Fund Activity: Q1 2026 in Review
124 of the 8,126 institutional investors tracked by Wall St. Rank reported a position in Septerna Inc (SEPN) for Q1 2026, worth a combined $1.1B — down 14% from $1.27B a quarter earlier.
Buyers outnumbered sellers: 28 funds opened new SEPN positions and 24 closed out — a net gain of 4 holders — while 43 added to existing stakes and 30 trimmed.
The largest buyer was Janus Henderson Group, opening a new position worth an estimated $23.4M. The largest seller was Perceptive Advisors, exiting entirely with an estimated $12.1M sold.
- 124 institutional investors held Septerna Inc (SEPN) as of Q1 2026, up from 122 in Q4 2025.
- Funds reported $1.1B of Septerna Inc stock for Q1 2026, down 14% quarter-over-quarter.
- 28 funds opened new Septerna Inc positions in Q1 2026 and 24 closed out, a net change of +4 holders.
- The largest Septerna Inc buyer in Q1 2026 was Janus Henderson Group, an estimated $23.4M added.
- The largest Septerna Inc seller in Q1 2026 was Perceptive Advisors, an estimated $12.1M sold.
Based on aggregated 13F filings for Q1 2026.