SEPN

Septerna, Inc. Common Stock
SEPN

Overview Fund Activity

88 hedge funds and large institutions have $468M invested in Septerna, Inc. Common Stock in 2025 Q2 according to their latest regulatory filings, with 25 funds opening new positions, 30 increasing their positions, 19 reducing their positions, and 6 closing their positions.

Holders
88
Holders Change
+17
Holders Change %
+23.94%
% of All Funds
1.18%
Holding in Top 10
4
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.05%
New
25
Increased
30
Reduced
19
Closed
6
Calls
$148K
Puts
$7M
Net Calls
-$6.85M
Net Calls Change
-$6.56M

Top Buyers

1
DCM
1
Driehaus Capital Management
Illinois
$49.5M
2
PA
2
Perceptive Advisors
New York
$5.72M
3
VA
3
VR Adviser
New York
$5.71M
4
Vanguard Group
4
Vanguard Group
Pennsylvania
$14.9M
5
BlackRock
5
BlackRock
New York
$14.7M

Top Sellers

1
DTC
1
Deep Track Capital
Connecticut
$1.29M
2
CCM
2
Catalio Capital Management
New York
$3.11M
3
SCM
3
Soleus Capital Management
Connecticut
$798K
4
Millennium Management
4
Millennium Management
New York
$549K
5
WP
5
Woodline Partners
California
$2.99M
Name Market Value Shares Shares
Change 		Shares
Change %
RCM
1
RA Capital Management
Massachusetts
$73.9M 6,995,858 – –
TGV
2
TRV GP V
Massachusetts
$65.7M 6,215,591 – –
DCM
3
Driehaus Capital Management
Illinois
$49.5M 4,680,431 +1,557,823 +50%
BI
4
BVF Inc
California
$46.5M 4,396,124 – –
TGV
5
TRV GP VI
Massachusetts
$44.5M 4,211,659 – –
SB
6
Samsara BioCapital
California
$33.3M 3,149,128 – –
SL
7
Siren LLC
Connecticut
$23.3M 2,202,514 – –
Goldman Sachs
8
Goldman Sachs
New York
$15M 1,416,314 -33,085 -2%
Vanguard Group
9
Vanguard Group
Pennsylvania
$14.9M 1,414,363 +419,319 +42%
BlackRock
10
BlackRock
New York
$14.7M 1,390,800 +132,487 +11%
ACA
11
Avoro Capital Advisors
New York
$13.1M 1,237,500 -100,000 -7%
ACM
12
ADAR1 Capital Management
Texas
$8.96M 847,227 +126,379 +18%
CC
13
Checkpoint Capital
California
$6.2M 586,473 -238,405 -29%
SCM
14
Sio Capital Management
New York
$6.18M 584,435 -204,235 -26%
CC
15
Casdin Capital
New York
$5.85M 553,268 – –
PA
16
Perceptive Advisors
New York
$5.72M 541,450 +541,450 New
VA
17
VR Adviser
New York
$5.71M 540,453 +540,453 New
Geode Capital Management
18
Geode Capital Management
Massachusetts
$5.16M 487,956 +78,316 +19%
State Street
19
State Street
Massachusetts
$3.91M 369,992 +25,388 +7%
CCM
20
Catalio Capital Management
New York
$3.11M 294,360 -729,885 -71%
WP
21
Woodline Partners
California
$2.99M 282,585 -300,000 -51%
Universal-Beteiligungs- und Servicegesellschaft
22
Universal-Beteiligungs- und Servicegesellschaft
Germany
$2.35M 222,702 +119,953 +117%
Charles Schwab
23
Charles Schwab
California
$1.64M 154,781 +36,330 +31%
Northern Trust
24
Northern Trust
Illinois
$1.63M 154,344 -3,696 -2%
DTC
25
Deep Track Capital
Connecticut
$1.29M 121,716 -1,791,213 -94%
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