Septerna Inc
SEPN
82 hedge funds and large institutions have $838M invested in Septerna Inc in 2025 Q3 according to their latest regulatory filings, with 10 funds opening new positions, 31 increasing their positions, 17 reducing their positions, and 16 closing their positions.
82% more repeat investments, than reductions
Existing positions increased: 31 | Existing positions reduced: 17
78% more capital invested
Capital invested by funds: $470M → $838M (+$368M)
0.21% more ownership
Funds ownership: 99.71% → 99.92% (+0.21%)
0% more funds holding in top 10
Funds holding in top 10: 4 → 4 (0)
8% less funds holding
Funds holding: 89 → 82 (-7)
38% less first-time investments, than exits
New positions opened: 10 | Existing positions closed: 16
88% less call options, than puts
Call options by funds: $1.7M | Put options by funds: $14M
Top Buyers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
Millennium Management
New York
|
+$4.36M |
| 2 |
ACM
ADAR1 Capital Management
Austin,
Texas
|
+$4.32M |
| 3 |
DCM
Driehaus Capital Management
Chicago,
Illinois
|
+$3.14M |
| 4 |
Invesco
Atlanta,
Georgia
|
+$2.17M |
| 5 |
Vanguard Group
Malvern,
Pennsylvania
|
+$1.37M |
Top Sellers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
SCM
Sio Capital Management
New York
|
-$5.19M |
| 2 |
BI
BVF Inc
San Francisco,
California
|
-$4.99M |
| 3 |
CC
Checkpoint Capital
San Francisco,
California
|
-$3.98M |
| 4 |
Susquehanna International Group
Bala Cynwyd,
Pennsylvania
|
-$2.19M |
| 5 |
DTC
Deep Track Capital
Greenwich,
Connecticut
|
-$1.29M |
SEPN Hedge Fund Activity: Q3 2025 in Review
82 of the 7,641 institutional investors tracked by Wall St. Rank reported a position in Septerna Inc (SEPN) for Q3 2025, worth a combined $838M — up 78% from $470M a quarter earlier.
Sellers outnumbered buyers: 16 funds closed out of SEPN and 10 opened new positions — a net loss of 6 holders — while 17 trimmed existing stakes and 31 added.
The largest buyer was Millennium Management, adding an estimated $4.36M. The largest seller was Sio Capital Management, cutting an estimated $5.19M.
- 82 institutional investors held Septerna Inc (SEPN) as of Q3 2025, down from 89 in Q2 2025.
- Funds reported $838M of Septerna Inc stock for Q3 2025, up 78% quarter-over-quarter.
- 10 funds opened new Septerna Inc positions in Q3 2025 and 16 closed out, a net change of -6 holders.
- The largest Septerna Inc buyer in Q3 2025 was Millennium Management, an estimated $4.36M added.
- The largest Septerna Inc seller in Q3 2025 was Sio Capital Management, an estimated $5.19M sold.
Based on aggregated 13F filings for Q3 2025.