Septerna Inc
SEPN
71 hedge funds and large institutions have $262M invested in Septerna Inc in 2025 Q1 according to their latest regulatory filings, with 19 funds opening new positions, 25 increasing their positions, 12 reducing their positions, and 19 closing their positions.
108% more repeat investments, than reductions
Existing positions increased: 25 | Existing positions reduced: 12
2.52% more ownership
Funds ownership: 99.39% → 101.91% (+2.5%)
0% more funds holding
Funds holding: 71 → 71 (0)
0% more first-time investments, than exits
New positions opened: 19 | Existing positions closed: 19
20% less funds holding in top 10
Funds holding in top 10: 5 → 4 (-1)
65% less call options, than puts
Call options by funds: $157K | Put options by funds: $444K
74% less capital invested
Capital invested by funds: $1.01B → $262M (-$748M)
Top Buyers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
BI
BVF Inc
San Francisco,
California
|
+$22.2M |
| 2 |
TGV
TRV GP VI
Boston,
Massachusetts
|
+$12.1M |
| 3 |
CC
Checkpoint Capital
San Francisco,
California
|
+$9.42M |
| 4 |
ACM
ADAR1 Capital Management
Austin,
Texas
|
+$8.23M |
| 5 |
DCM
Driehaus Capital Management
Chicago,
Illinois
|
+$6.09M |
Top Sellers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
Janus Henderson Group
London,
|
-$25.1M |
| 2 |
DM
Deerfield Management
New York
|
-$19.7M |
| 3 |
PA
Perceptive Advisors
New York
|
-$17.2M |
| 4 |
CAM
Cormorant Asset Management
Boston,
Massachusetts
|
-$12.8M |
| 5 |
Fidelity Investments
Boston,
Massachusetts
|
-$10.9M |
SEPN Hedge Fund Activity: Q1 2025 in Review
71 of the 7,473 institutional investors tracked by Wall St. Rank reported a position in Septerna Inc (SEPN) for Q1 2025, worth a combined $262M — down 74% from $1.01B a quarter earlier.
Fund positioning in SEPN was balanced in Q1 2025: 19 funds opened new positions, 19 closed out, 25 added to existing stakes and 12 trimmed.
The largest buyer was BVF Inc, adding an estimated $22.2M. The largest seller was Janus Henderson Group, exiting entirely with an estimated $25.1M sold.
- 71 institutional investors held Septerna Inc (SEPN) as of Q1 2025, unchanged from Q4 2024.
- Funds reported $262M of Septerna Inc stock for Q1 2025, down 74% quarter-over-quarter.
- 19 funds opened new Septerna Inc positions in Q1 2025 and 19 closed out, a net change of 0 holders.
- The largest Septerna Inc buyer in Q1 2025 was BVF Inc, an estimated $22.2M added.
- The largest Septerna Inc seller in Q1 2025 was Janus Henderson Group, an estimated $25.1M sold.
Based on aggregated 13F filings for Q1 2025.