Septerna Inc
SEPN
154 hedge funds and large institutions have $1.58B invested in Septerna Inc in 2026 Q2 according to their latest regulatory filings, with 48 funds opening new positions, 49 increasing their positions, 32 reducing their positions, and 16 closing their positions.
200% more first-time investments, than exits
New positions opened: 48 | Existing positions closed: 16
163% more call options, than puts
Call options by funds: $35M | Put options by funds: $13.3M
53% more repeat investments, than reductions
Existing positions increased: 49 | Existing positions reduced: 32
44% more capital invested
Capital invested by funds: $1.1B → $1.58B (+$483M)
24% more funds holding
Funds holding: 124 → 154 (+30)
2.99% more ownership
Funds ownership: 101.82% → 104.81% (+3%)
0% more funds holding in top 10
Funds holding in top 10: 4 → 4 (0)
Top Buyers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
Loomis, Sayles & Company
Boston,
Massachusetts
|
+$17.7M |
| 2 |
AG
Algert Global
San Francisco,
California
|
+$10.7M |
| 3 |
CCM
Catalio Capital Management
New York
|
+$6.86M |
| 4 |
FLAM
First Light Asset Management
Edina,
Minnesota
|
+$6.54M |
| 5 |
LP
Longaeva Partners
Chicago,
Illinois
|
+$6.34M |
Top Sellers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
BI
BVF Inc
San Francisco,
California
|
-$32.5M |
| 2 |
VA
VR Adviser
New York
|
-$12.2M |
| 3 |
ACM
ADAR1 Capital Management
Austin,
Texas
|
-$4.23M |
| 4 |
SL
Siren LLC
Greenwich,
Connecticut
|
-$2.84M |
| 5 |
CC
Checkpoint Capital
San Francisco,
California
|
-$2.41M |
SEPN Hedge Fund Activity: Q2 2026 in Review
154 of the 8,317 institutional investors tracked by Wall St. Rank reported a position in Septerna Inc (SEPN) for Q2 2026, worth a combined $1.58B — up 44% from $1.1B a quarter earlier.
Buyers outnumbered sellers: 48 funds opened new SEPN positions and 16 closed out — a net gain of 32 holders — while 49 added to existing stakes and 32 trimmed.
The largest buyer was Loomis, Sayles & Company, opening a new position worth an estimated $17.7M. The largest seller was BVF Inc, exiting entirely with an estimated $32.5M sold.
- 154 institutional investors held Septerna Inc (SEPN) as of Q2 2026, up from 124 in Q1 2026.
- Funds reported $1.58B of Septerna Inc stock for Q2 2026, up 44% quarter-over-quarter.
- 48 funds opened new Septerna Inc positions in Q2 2026 and 16 closed out, a net change of +32 holders.
- The largest Septerna Inc buyer in Q2 2026 was Loomis, Sayles & Company, an estimated $17.7M added.
- The largest Septerna Inc seller in Q2 2026 was BVF Inc, an estimated $32.5M sold.
Based on aggregated 13F filings for Q2 2026.