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SEPN

Septerna Inc
SEPN

71 hedge funds and large institutions have $1.01B invested in Septerna Inc in 2024 Q4 according to their latest regulatory filings, with 71 funds opening new positions, increasing their positions, reducing their positions, and closing their positions.

New
Increased
Maintained
Reduced
Closed

99.39% more ownership

Funds ownership: 0% → 99.39% (+99%)

Holders
71
Holders Change
+71
Holders Change %
–
% of All Funds
0.94%
Holding in Top 10
5
Holding in Top 10 Change
+5
Holding in Top 10 Change %
% of All Funds
0.07%
New
71
Increased
–
Reduced
–
Closed
–
Calls
–
Puts
–
Net Calls
–
Net Calls Change
–

Top Buyers

Rank Fund Capital Flow
1
RCM
RA Capital Management
Massachusetts
+$165M
2
SB
Samsara BioCapital
California
+$65.5M
3
DCM
Driehaus Capital Management
Illinois
+$61.2M
4
BI
BVF Inc
California
+$58M
5
SL
Siren LLC
Connecticut
+$52.1M

Top Sellers

No sellers this quarter
Name Holding Trade Value Shares
Change 		Change in
Stake
RCM
1
RA Capital Management
Massachusetts
$160M +$165M +6,995,858 New
TGV
2
TRV GP V
Massachusetts
$142M +$147M +6,215,591 New
TGV
3
TRV GP VI
Massachusetts
$72.2M +$74.5M +3,152,456 New
SB
4
Samsara BioCapital
California
$63.4M +$65.5M +2,768,520 New
DCM
5
Driehaus Capital Management
Illinois
$59.3M +$61.2M +2,589,553 New
BI
6
BVF Inc
California
$56.2M +$58M +2,452,024 New
SL
7
Siren LLC
Connecticut
$50.4M +$52.1M +2,202,514 New
DTC
8
Deep Track Capital
Connecticut
$43.8M +$45.2M +1,912,929 New
BlackRock
9
BlackRock
New York
$38.4M +$39.7M +1,677,135 New
Goldman Sachs
10
Goldman Sachs
New York
$38.3M +$39.6M +1,674,357 New
ACA
11
Avoro Capital Advisors
New York
$25.4M +$26.2M +1,110,000 New
Janus Henderson Group
12
Janus Henderson Group
United Kingdom
$25.1M +$25.9M +1,096,302 New
CCM
13
Catalio Capital Management
New York
$23.5M +$24.2M +1,024,245 New
Fidelity Investments
14
Fidelity Investments
Massachusetts
$23M +$23.7M +1,002,958 New
Vanguard Group
15
Vanguard Group
Pennsylvania
$22.6M +$23.3M +985,032 New
DM
16
Deerfield Management
New York
$19.7M +$20.4M +861,814 New
PA
17
Perceptive Advisors
New York
$17.2M +$17.7M +750,000 New
SCM
18
Soleus Capital Management
Connecticut
$15.5M +$16M +675,409 New
CAM
19
Cormorant Asset Management
Massachusetts
$12.8M +$13.2M +560,000 New
CC
20
Casdin Capital
New York
$12.7M +$13.1M +553,268 New
T. Rowe Price Associates
21
T. Rowe Price Associates
Maryland
$11.9M +$12.3M +518,588 New
Citadel Advisors
22
Citadel Advisors
Florida
$9.27M +$9.57M +404,882 New
Geode Capital Management
23
Geode Capital Management
Massachusetts
$8.72M +$9M +380,577 New
Adage Capital Partners
24
Adage Capital Partners
Massachusetts
$6.87M +$7.09M +300,000 New
WP
25
Woodline Partners
California
$6.87M +$7.09M +300,000 New
1
2 3

SEPN Hedge Fund Activity: Q4 2024 in Review

71 of the 7,593 institutional investors tracked by Wall St. Rank reported a position in Septerna Inc (SEPN) for Q4 2024, worth a combined $1.01B.

Buyers outnumbered sellers: 71 funds opened new SEPN positions and 0 closed out — a net gain of 71 holders — while 0 added to existing stakes and 0 trimmed.

The largest buyer was RA Capital Management, opening a new position worth an estimated $165M.

  • 71 institutional investors held Septerna Inc (SEPN) as of Q4 2024, up from 0 in Q3 2024.
  • Funds reported $1.01B of Septerna Inc stock for Q4 2024.
  • 71 funds opened new Septerna Inc positions in Q4 2024 and 0 closed out, a net change of +71 holders.
  • The largest Septerna Inc buyer in Q4 2024 was RA Capital Management, an estimated $165M added.

Based on aggregated 13F filings for Q4 2024.