SEPN

Septerna, Inc. Common Stock
SEPN

Overview Fund Activity

89 hedge funds and large institutions have $470M invested in Septerna, Inc. Common Stock in 2025 Q2 according to their latest regulatory filings, with 25 funds opening new positions, 31 increasing their positions, 19 reducing their positions, and 6 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
89
Holders Change
+18
Holders Change %
+25.35%
% of All Funds
1.19%
Holding in Top 10
4
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.05%
New
25
Increased
31
Reduced
19
Closed
6
Calls
$440K
Puts
$12.6M
Net Calls
-$12.1M
Net Calls Change
-$11.9M

Top Buyers

1
DCM
Driehaus Capital Management
Illinois
$49.5M
2
PA
Perceptive Advisors
New York
$5.72M
3
VA
VR Adviser
New York
$5.71M
4
Vanguard Group
Vanguard Group
Pennsylvania
$14.9M
5
Susquehanna International Group
Susquehanna International Group
Pennsylvania
$1.76M

Top Sellers

1
DTC
Deep Track Capital
Connecticut
$1.29M
2
CCM
Catalio Capital Management
New York
$3.11M
3
SCM
Soleus Capital Management
Connecticut
$798K
4
Millennium Management
Millennium Management
New York
$549K
5
WP
Woodline Partners
California
$2.99M
Name Holding Trade Value Shares
Change 		Shares
Change %
RCM
1
RA Capital Management
Massachusetts
$73.9M – – –
TGV
2
TRV GP V
Massachusetts
$65.7M – – –
DCM
3
Driehaus Capital Management
Illinois
$49.5M +$16.5M +1,557,823 +50%
BI
4
BVF Inc
California
$46.5M – – –
TGV
5
TRV GP VI
Massachusetts
$44.5M – – –
SB
6
Samsara BioCapital
California
$33.3M – – –
SL
7
Siren LLC
Connecticut
$23.3M – – –
Goldman Sachs
8
Goldman Sachs
New York
$15M -$350K -33,085 -2%
Vanguard Group
9
Vanguard Group
Pennsylvania
$14.9M +$4.43M +419,319 +42%
BlackRock
10
BlackRock
New York
$14.7M +$1.4M +132,487 +11%
ACA
11
Avoro Capital Advisors
New York
$13.1M -$1.06M -100,000 -7%
ACM
12
ADAR1 Capital Management
Texas
$8.96M +$1.34M +126,379 +18%
CC
13
Checkpoint Capital
California
$6.2M -$2.52M -238,405 -29%
SCM
14
Sio Capital Management
New York
$6.18M -$2.16M -204,235 -26%
CC
15
Casdin Capital
New York
$5.85M – – –
PA
16
Perceptive Advisors
New York
$5.72M +$5.72M +541,450 New
VA
17
VR Adviser
New York
$5.71M +$5.71M +540,453 New
Geode Capital Management
18
Geode Capital Management
Massachusetts
$5.16M +$828K +78,316 +19%
State Street
19
State Street
Massachusetts
$3.91M +$268K +25,388 +7%
CCM
20
Catalio Capital Management
New York
$3.11M -$7.71M -729,885 -71%
WP
21
Woodline Partners
California
$2.99M -$3.17M -300,000 -51%
Universal-Beteiligungs- und Servicegesellschaft
22
Universal-Beteiligungs- und Servicegesellschaft
Germany
$2.35M +$1.27M +119,953 +117%
Susquehanna International Group
23
Susquehanna International Group
Pennsylvania
$1.76M +$1.49M +141,297 +561%
Charles Schwab
24
Charles Schwab
California
$1.64M +$384K +36,330 +31%
Northern Trust
25
Northern Trust
Illinois
$1.63M -$39.1K -3,696 -2%
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