Septerna Inc
SEPN
90 hedge funds and large institutions have $470M invested in Septerna Inc in 2025 Q2 according to their latest regulatory filings, with 25 funds opening new positions, 31 increasing their positions, 19 reducing their positions, and 7 closing their positions.
257% more first-time investments, than exits
New positions opened: 25 | Existing positions closed: 7
63% more repeat investments, than reductions
Existing positions increased: 31 | Existing positions reduced: 19
23% more funds holding
Funds holding: 73 → 90 (+17)
0% more funds holding in top 10
Funds holding in top 10: 4 → 4 (0)
2.2% less ownership
Funds ownership: 101.92% → 99.72% (-2.2%)
16% less capital inflows, than outflows
Capital inflows: $33.8M | Capital outflows: $40.4M
97% less call options, than puts
Call options by funds: $440K | Put options by funds: $12.6M
Top Buyers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
Driehaus Capital Management
Chicago,
Illinois
|
+$12.8M |
| 2 |
Perceptive Advisors
New York
|
+$4.46M |
| 3 |
VR Adviser
New York
|
+$4.45M |
| 4 |
Vanguard Group
Malvern,
Pennsylvania
|
+$3.45M |
| 5 |
Susquehanna International Group
Bala Cynwyd,
Pennsylvania
|
+$1.16M |
Top Sellers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
Deep Track Capital
Greenwich,
Connecticut
|
-$14.8M |
| 2 |
Catalio Capital Management
New York
|
-$6.01M |
| 3 |
Soleus Capital Management
Greenwich,
Connecticut
|
-$5.57M |
| 4 |
Millennium Management
New York
|
-$3.17M |
| 5 |
Woodline Partners
San Francisco,
California
|
-$2.47M |
SEPN Hedge Fund Activity: Q2 2025 in Review
90 of the 7,630 institutional investors tracked by Wall St. Rank reported a position in Septerna Inc (SEPN) for Q2 2025, worth a combined $470M — up 79% from $262M a quarter earlier.
Buyers outnumbered sellers: 25 funds opened new SEPN positions and 7 closed out — a net gain of 18 holders — while 31 added to existing stakes and 19 trimmed.
The largest buyer was Driehaus Capital Management, adding an estimated $12.8M. The largest seller was Deep Track Capital, cutting an estimated $14.8M.
- 90 institutional investors held Septerna Inc (SEPN) as of Q2 2025, up from 73 in Q1 2025.
- Funds reported $470M of Septerna Inc stock for Q2 2025, up 79% quarter-over-quarter.
- 25 funds opened new Septerna Inc positions in Q2 2025 and 7 closed out, a net change of +18 holders.
- The largest Septerna Inc buyer in Q2 2025 was Driehaus Capital Management, an estimated $12.8M added.
- The largest Septerna Inc seller in Q2 2025 was Deep Track Capital, an estimated $14.8M sold.
Based on aggregated 13F filings for Q2 2025.